Staphylococcus aureus ⇒ Staphylococcus {10000114}

References Notes

Shared Reference Notes

• [1.28] 
  - Staphylococcal bacterial infection and bacterial toxins can trigger an immune response that leads to the production of dietary-antigen-specific IgE antibodies in mice, which are limited to the intestine.
  - Following subsequent oral ingestion of the respective dietary antigen, an IgE- and mast-cell-dependent mechanism induced increased visceral pain.
  -This aberrant pain signalling resulted from histamine receptor H1-mediated sensitization of visceral afferents.
  - Injection of food antigens (gluten, wheat, soy and milk) into the rectosigmoid mucosa of patients with irritable bowel syndrome induced local oedema and mast cell activation.
• [1.12] 
  - Staphylococcus aureus > contribute to disease progression
• [1.4] 
  - increased abundance of S. aureus with depletion of S. epidermidis and Corynebacterium spp. among AD patients.
  - S. epidermidis, a commensal present on non–inflamed skin, appears to be S. aureus best antagonist.
  - less severe flares of AD had higher counts of S. epidermidis whereas the more severe flares were associated with S. aureus
• - Staphylococcus hominis, S. lugdunensis and S. epidermidis produce several molecules capable of synergizing the innate antimicrobial response against S. aureus
• [1.5] 
  - samples where S. aureus was highly abundant, lower abundances of S. hominis and Cutibacterium acnes were observed. M. osloensis and M. luteus were more abundant in AD.
  - The flexures exhibited lower alpha-diversity and were colonized by S. aureus, accompanied by S. epidermidis in lesions. Malassezia species were absent on the neck in AD.
• [1.2] 
  - S. aureus, a dominant species among the family of Staphylococcae, can be 100 times more abundant in AD skin compared to normal healthy skin.
  - AD is associated with a depletion in the coagulase-negative staphylococcal species (CoNS), such as S. epidermidis, S. hominis, and other skin commensal bacterial communities, including Streptococcus salivarius, Propionibacterium, Streptococcus, Acinetobacter, Corynebacterium, Prevotella and Proteobacteria.
  - AD patients exhibit abundant S. aureus in their gut microbiota