Bacillus ⇒ Bacillus subtilis {10000218} Record Keys Parent:Bacillus Definition:Bacillus subtilis Details Initialisation date:2019-08-11 LinksSource Meta Information Rank: Species Domain: Bacteria Enzyme:[ ] Function:Starch-degrading, Anti-inflammatory Notes: -Bacillus subtilis, also called hay bacteria, is often found in nature. Especially in the upper soil layers, but also in dust, water, air and in people. - For metabolism, it has some enzymes for branched carbohydrates and proteins, but still prefers glucose as an energy source. - Even in the absence of oxygen, this bacterium can continue to live and even grow slowly. Typical fermentation products such as ethanol and lactic acid are then created. - In medicine it is used to treat diarrhea, dyspepsia and enterocolitis. The health-promoting effect may lie in the synthesis of antibiotic substances and the activation of immune cells. - As a probiotic, it also increases the survivability of the lactic acid bacteria L. reuteri and L. acidophilus, which reduces the proportion of harmful bacteria. Under extremely rare circumstances, however, it can also have a pathogenic effect. - In the food industry, the B. subtilis natto strain is used to make the Japanese dish natto (fermented soybeans) and other dishes. - Its spores can survive in space for up to six years.Shared Reference Notes [1.1] [1.2] - #Myristic acid is involved in the post-translational folding of proteins in humansan d can inhibit the activity of some bacterial ATP-binding cassette (ABC) transporters, for instance, observed for #Bacillus multidrug-resistance ATP (BmrA) of #Bacillus subtilis (B. subtilis). [1.3] - several microbiota species produce #Dopamine including #Bacillus cereus, B. subtilis and #Staphylococcus aureus [1.4] [#Celiac Disease] - Bacillus subtilis LZU-GM was isolated from Pakistani traditional fermented sourdough and could degrade 73.7% of #Gluten in 24 h in vitro. - The #Gluten degradation was 3-fold higher in the small intestine of the strain LZU-GM treated mice group. - #Gluten-treated mice established positive antigliadin antibodies (AGA) in serum (IgA, IgG, and anti-TG2 antibodies) as compared to the strain LZU-GM treatment group. - the number of IFN-γ, TNF-α, #IL-10, and COX-2 cells decrease in the lamina propria of the strain LZU-GM treatment group. - Microbial community bar plot analysis showed that #Lactobacillus, #Dubosiella, and #Enterococcus genera were restored and stabilized in the LZU-GM treatment group while #Blautia and #Ruminococcus were found lower. [1.5] [#Clostridioides difficile] [#Berberine] - BBR has direct inhibitory effects on #Bacteria such as #Clostridium difficile, #Actinobacillus, and Bacillus subtilis [1.6] [#Short peptide bacteriocins] - #Subtilosin A, an SPB produced by Bacillus subtilis, which is capable of exerting strong inhibitory activity against #Streptococcus pyogenes at a very low concentration (1.25 µg/mL), but against #Streptococcus gordonii had an MIC value of 83.25 µg/mL [1.7] - Othe peptide antimicrobials include the #Colicins of #Escherichia coli, the #Pyocins of #Pseudomonas aeruginosa, the #Halocins of #Halobacteria, #Subtilin of Bacillus subtilis, the #Lantibiotics of #Lactic acid bacteria (LAB), and other #Bacteriocins. [1.8] [#Entamoeba histolytica] - E. histolytica #Cysteine proteinases (CPs) play a crucial role in the degradation process of Bacillus subtilis biofilm. - These proteinases target TasA, a major component of the B. subtilis biofilm matrix, also contributing to the adhesion of the parasite to the biofilm. - They are also involved in the degradation of biofilms formed by Gram-negative and Gram-positive enteric pathogens. Furthermore, biofilms also play an important role in protecting trophozoites against #Oxidative stress.References Notes[ ]
