Lab ⇒ Natural Skin Microbiome {40000556}

References Notes

Shared Reference Notes

• [1.1] 
  - The most dominant genus in the skin is Staphylococcus, Propionibacterium, Corynebacterium, and Streptococcus. - Furthermore, oilier sites have significant dominance of Propionibacterium species (lipophilic), whereas in humid niches, Staphylococcus and Corynebacterium species thrive
• - Skin microbiome > #Children have a marked profile of Ascomycetes and lower levels of Malassezia when compared to adults.
• [1.2] 
  - The sebum produced by the sebaceous gland lubricates the hair and skin. - Sapienic acid produced by the hydrolysis of sebum by commensal microbes acts alongside other antimicrobial peptides such as cathelicidin, beta-defensins, and antimicrobial histones to control microbial colonization. - Eccrine sweat secreted directly onto the skin surface creates unfavorable conditions for the survival and proliferation of microbes. - The highly colonized dermal appendage is home to a variety of microbes. This environment allows for ample interaction between microorganisms and host cells.
• - the moist sites of skin are primarily colonized by members of the genera #Staphylococcus and #Corynebacterium.
• - Members of the genus #Cutibacterium (previously known as #Propionibacterium), dominate the sebaceous (oily) sites of the human skin.
• [#Gender] - female genital tract is characterized by a predominance of #Lactobacillus.
• [#Staphylococcus aureus] - Other Staphylococcus spp. that inhabit the skin of humans, for example #Staphylococcus hominis and #Staphylococcus lugdunensis, may produce antimicrobial peptides that specifically inhibit colonization by S. aureus.
• - #Staphylococcus epidermidis, can also interact with the host’s keratinocytes directly, thereby inducing the production of antimicrobial peptides via immune cell signaling.