Prevotellaceae ⇒ Bacteroidales {10000113}
| Organism: | Prevotellaceae |
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| Parent: |
| Initialisation date: | 2020-09-06 |
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| Rank: | Family |
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| Domain: | Bacteria |
| Zone: | [ ] |
| Enzyme: | [ ] |
| Function: | [ ] |
Notes:
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References Notes
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Shared Reference Notes
- [1.19] [#Parkinson’s Disease]
- Prevotellaceae (Prevotella), #Ruminococcaceae (#Faecalibacterium), #Lachnospiraceae (#Blautia, #Roseburia) that produce SCFA and help in the synthesis of mucin to maintain the intestinal integrity are considerably lower in abundance in PD - [1.16] [#Parkinson’s Disease] [#Lactobacillus]
- most PD patients (about 70% of patients) develop gastrointestinal disorders such as constipation, dysphagia, and gastroesophageal reflux. Strikingly, these gastrointestinal dysfunctions (particularly constipation and delayed gastric emptying) can be detected up to 20 years prior to PD diagnosis. - reduction in their number of Prevotellaceae bacteria compared to controls. Strikingly, this alteration was associated with the severity of the motor symptoms. - PD patients may exhibit not only a decreased abundance of Prevotella but also an increased abundance of Lactobacilliceae. - These alterations may be associated with reduced levels of #Ghrelin, an important gut hormone involved in the survival and efficacy of dopaminergic neurons.