Disease ⇒ Chronic kidney disease {40000186}
Type: | Disease |
---|---|
Definition: | Chronic kidney disease |
Parent: | [ ] |
Initialisation date: | 2020-10-13 |
---|---|
Other Terms: | CKD |
MedDra ID: | 10064848 |
---|---|
MedDra Level: | pt |
ICD: | [ ] |
Zone: | [ ] |
Mechanism: | [ ] |
Notes:
[ ]
References Notes
[ ]
Shared Reference Notes
- [1.13]
- In chronic kidney disease (CKD), the “healthy” microbiota structure is disrupted, and intestinal microbes produce large quantities of uremic solutes responsible for renal damage; on the other hand, the uremic state, fueled by reduced renal clearance, causes shifts in microbial metabolism and composition, hence creating a vicious cycle in which dysbiosis and renal dysfunction are progressively worsened. - [1.14]
- Saccharibacteria (per 1-SD higher in the log-transformed abundance) could potentially decrease the concentration of serum creatinine and increase the estimated glomerular filtration rate which might help improve renal function. - [1.12]
- Curcumin > significantly reduced plasma pro-inflammatory mediators (CCL-2, IFN-γ, and IL-4) and lipid peroxidation.
- After 6 months of curcumin supplementation > significantly lower Escherichia-Shigella and significantly higher Lachnoclostridium .
- In the last 3 months of supplementation > significantly higher Lactobacillaceae spp.. - [1.8]
- Bacterial species involved in butyrate production, indole synthesis and mucin degradation were also related to CKD. - [1.16]
- Chronic kidney disease > decreased Indole, indole-3-carboxaldehyde and indole-3-propionic acid