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Microbiome & Chronic Diseases

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Disease ⇒ Chronic kidney disease {40000186}

Record Keys


Type:
Disease
Definition:
Chronic kidney disease
Parent:[  ]

Details


Initialisation date:
2020-10-13
Other Terms:
CKD

Meta Information


MedDra ID:
10064848
MedDra Level:
pt
ICD:[  ]
Zone:[  ]
Mechanism:[  ]

Notes:


[  ]

References Notes


[  ]

Shared Reference Notes


  • [1.13
    - In chronic kidney disease (CKD), the “healthy” microbiota structure is disrupted, and intestinal microbes produce large quantities of uremic solutes responsible for renal damage; on the other hand, the uremic state, fueled by reduced renal clearance, causes shifts in microbial metabolism and composition, hence creating a vicious cycle in which dysbiosis and renal dysfunction are progressively worsened.
  • [1.14
    - Saccharibacteria (per 1-SD higher in the log-transformed abundance) could potentially decrease the concentration of serum creatinine and increase the estimated glomerular filtration rate which might help improve renal function.
  • [1.12
    - Curcumin > significantly reduced plasma pro-inflammatory mediators (CCL-2, IFN-γ, and IL-4) and lipid peroxidation.
    - After 6 months of curcumin supplementation > significantly lower Escherichia-Shigella and significantly higher Lachnoclostridium .
    - In the last 3 months of supplementation > significantly higher Lactobacillaceae spp..
  • [1.8
    - Bacterial species involved in butyrate production, indole synthesis and mucin degradation were also related to CKD.
  • [1.16
    - Chronic kidney disease > decreased Indole, indole-3-carboxaldehyde and indole-3-propionic acid

Common References