Disease ⇒ Chronic kidney disease {40000186}

Record Keys
Type:	Disease
Definition:	Chronic kidney *disease*
Parent:	[ ]

Details
Initialisation date:	2020-10-13
Other Terms:	CKD

Meta Information
MedDra ID:	10064848
MedDra Level:	pt
ICD:	[ ]
Zone:	[ ]
Mechanism:	[ ]

Notes:

[ ]

References Notes

[ ]

Shared Reference Notes

[1.13]
- In chronic kidney disease (CKD), the “healthy” microbiota structure is disrupted, and intestinal microbes produce large quantities of uremic solutes responsible for renal damage; on the other hand, the uremic state, fueled by reduced renal clearance, causes shifts in microbial metabolism and composition, hence creating a vicious cycle in which dysbiosis and renal dysfunction are progressively worsened.
[1.14]
- Saccharibacteria (per 1-SD higher in the log-transformed abundance) could potentially decrease the concentration of serum creatinine and increase the estimated glomerular filtration rate which might help improve renal function.
[1.12]
- Curcumin > significantly reduced plasma pro-inflammatory mediators (CCL-2, IFN-γ, and IL-4) and lipid peroxidation.
- After 6 months of curcumin supplementation > significantly lower Escherichia-Shigella and significantly higher Lachnoclostridium .
- In the last 3 months of supplementation > significantly higher Lactobacillaceae spp..
[1.8]
- Bacterial species involved in butyrate production, indole synthesis and mucin degradation were also related to CKD.
[1.16]
- Chronic kidney disease > decreased Indole, indole-3-carboxaldehyde and indole-3-propionic acid

↥ Abundance

‐ Acinetobacter ‎Buffy coat ‎Human [1.1]
‐ Actinomyces naeslundii ‎Supragingival plaque ‎Human [1.2]
‐ Actinomyces ‎Supragingival plaque ‎Human [1.2]
‐ Alloprevotella ‎Stool ‎Human [1.3]
‐ Anaerotruncus ‎Stool ‎Human [1.4]
‐ Bacillus ‎Buffy coat ‎Human [1.1]
‐ Bacteroides ‎Stool ‎Human [1.4]
‐ Bergeyella ‎Supragingival plaque ‎Human [1.2]
‐ Bifidobacterium ‎Stool ‎Human [1.5]
‐ Citrobacter ‎Stool ‎Human [1.6]
‐ Cloacibacillus ‎Stool ‎Human [1.4]
‐ Clostridium cluster IV ‎Stool ‎Human [1.3]
‐ Clostridium innocuum ‎Stool ‎Human [1.7]
‐ Clostridium ‎Stool ‎Human [1.8]
‐ Coprobacillus ‎Stool ‎Human [1.6]
‐ Corynebacterium ‎Supragingival plaque ‎Human [1.2]
‐ Deltaproteobacteria ‎Stool ‎Human [1.4]
‐ Desulfovibrio ‎Stool ‎Human [1.3]
‐ Eggerthella lenta ‎Stool ‎Human [1.8]
‐ Eggerthella ‎Stool ‎Human [1.7]
‐ Enterobacteriaceae ‎Stool ‎Human [1.9]
‐ Enterobacteriaceae ‎Stool ‎Human [1.8]
‐ Erysipelatoclostridium ‎Stool ‎Human [1.7]
‐ Escherichia coli ‎Stool ‎Human [1.9]
‐ Flavonifractor ‎Stool ‎Human [1.7]
‐ Hungatella ‎Stool ‎Human [1.10]
‐ Hyphomicrobium ‎Buffy coat ‎Human [1.1]
‐ Intestinimonas ‎Stool ‎Human [1.10]
‐ Lachnoclostridium ‎Stool ‎Human [1.5]
‐ Lactobacillus fermentum ‎Supragingival plaque ‎Human [1.2]
‐ Lactobacillus salivarius ‎Supragingival plaque ‎Human [1.2]
‐ Lactobacillus vaginalis ‎Supragingival plaque ‎Human [1.2]
‐ Lactobacillus ‎Stool ‎Human [1.6]
‐ Lysobacter ‎Buffy coat ‎Human [1.1]
‐ Marvinbryantia ‎Stool ‎Human [1.4]
‐ Neisseria ‎Stool ‎Human [1.5]
‐ Parabacteroides ‎Stool ‎Human [1.4]
‐ Paraprevotella ‎Stool ‎Human [1.4]
‐ Parasporobacterium ‎Stool ‎Human [1.4]
‐ Pseudarcicella ‎Buffy coat ‎Human [1.1]
‐ Pseudomonas ‎Buffy coat ‎Human [1.1]
‐ Pseudomonas ‎Stool ‎Human [1.10]
‐ Rothia ‎Supragingival plaque ‎Human [1.2]
‐ Ruminiclostridium ‎Stool ‎Human [1.7]
‐ Ruminococcus gnavus ‎Stool ‎Human [1.7]
‐ Ruminococcus torques ‎Stool ‎Human [1.6]
‐ Saccharibacteria ‎Ameliorative ‎Gut Lumen ‎Human
‐ Scardovia wiggsiae ‎Supragingival plaque ‎Human [1.2]
‐ Sediminibacterium ‎Buffy coat ‎Human [1.1]
‐ Sellimonas ‎Stool ‎Human [1.7]
‐ Serratia ‎Buffy coat ‎Human [1.1]
‐ Shigella ‎Stool ‎Human [1.10]
‐ Streptococcus mitis ‎Supragingival plaque ‎Human [1.2]
‐ Streptococcus mutans ‎Supragingival plaque ‎Human [1.2]
‐ Streptococcus ‎Stool ‎Human [1.5]
‐ Subdoligranulum ‎Stool ‎Human [1.5]
‐ Weissella ‎Stool ‎Human [1.7]
‐ Yersinia ‎Buffy coat ‎Human [1.1]

↧ Abundance

‐ Aanaerobacter ‎Stool ‎Human [1.4]
‐ Akkermansia ‎Stool ‎Human [1.3]
‐ Alcaligenaceae ‎Stool ‎Human [1.4]
‐ Bacteroides eggerthii ‎Stool ‎Human [1.8]
‐ Bacteroides fragilis ‎Stool ‎Human [1.4]
‐ Bacteroides ‎Stool ‎Human [1.5]
‐ Barnesiella ‎Stool ‎Human [1.4]
‐ Bifidobacterium ‎Stool ‎Human [1.4]
‐ Butyricicoccus ‎Stool ‎Human [1.4]
‐ Candidatus ‎Buffy coat ‎Human [1.1]
‐ Carnobacterium ‎Stool ‎Human [1.7]
‐ Catenibacterium ‎Stool ‎Human [1.4]
‐ Clostridium coccoides group ‎Stool ‎Human [1.4]
‐ Clostridium ‎Stool ‎Human [1.4]
‐ Collinsella ‎Stool ‎Human [1.7]
‐ Coprococcus ‎Stool ‎Human [1.4]
‐ Corynebacterium ‎Buffy coat ‎Human [1.1]
‐ Dialister ‎Stool ‎Human [1.4]
‐ Dorea ‎Stool ‎Human [1.4]
‐ Enterobacter ‎Stool ‎Human [1.5]
‐ Enterococcus ‎Stool ‎Human [1.4]
‐ Escherichia coli ‎Stool ‎Human [1.4]
‐ Eubacterium coprostanoligenes ‎Stool ‎Human [1.7]
‐ Eubacterium hallii ‎Stool ‎Human [1.7]
‐ Eubacterium rectale ‎Stool ‎Human [1.7]
‐ Faecalibacterium prausnitzii ‎Stool ‎Human [1.6]
‐ Faecalibacterium ‎Stool ‎Human [1.4]
‐ Hallella ‎Stool ‎Human [1.4]
‐ Lachnospira ‎Stool ‎Human [1.7]
‐ Megamonas ‎Stool ‎Human [1.10]
‐ Oribacterium ‎Stool ‎Human [1.4]
‐ Paracoccus ‎Buffy coat ‎Human [1.1]
‐ Parasutterella ‎Stool ‎Human [1.4]
‐ Pasteurellaceae ‎Stool ‎Human [1.4]
‐ Prevotellaceae ‎Stool ‎Human [1.10]
‐ Prevotella ‎Stool ‎Human [1.4, 1.8]
‐ Pseudomonadales ‎Stool ‎Human [1.4]
‐ Pseudomonas ‎Stool ‎Human [1.4]
‐ Pyramidobacter ‎Stool ‎Human [1.10]
‐ Rikenellaceae ‎Stool ‎Human [1.10]
‐ Romboutsia ‎Stool ‎Human [1.7]
‐ Roseburia faecis ‎Stool ‎Human [1.8]
‐ Roseburia ‎Stool ‎Human [1.11]
‐ Ruminococcaceae ‎Stool ‎Human [1.10]
‐ Ruminococcus ‎Stool ‎Human [1.7]
‐ Shigella ‎Stool ‎Human [1.5]
‐ Slackia ‎Stool ‎Human [1.4]
‐ Sphingomonas ‎Buffy coat ‎Human [1.1]
‐ Stenotrophomonas ‎Buffy coat ‎Human [1.1]
‐ Streptococcus ‎Stool ‎Human [1.9]
‐ Subdoligranulum ‎Stool ‎Human [1.7]
‐ Tyzzerella ‎Buffy coat ‎Human [1.1]
‐ Tyzzerella ‎Stool ‎Human [1.7]

Related Factor

‐ Curcumin Supplementation [1.12]

Subclass

[ ]

Related Metabolome

‐ Creatinin ‎↥ ‎Deteriorative

References

[ ]

Common References

[1.1] Blood microbiome profile in CKD: A pilot study [2019] [Clinical Journal of the American Society of Nephrology] [Journal] [80000967]
[1.2] Carious status and supragingival plaque microbiota in hemodialysis patients [2018] [PLOS ONE] [Journal] [80000880]
[1.3] Alterations to the gut microbiota and their correlation with inflammatory factors in chronic kidney disease [2019] [Frontiers in Cellular and Infection Microbiology] [Journal] [80001140]
[1.4] Alteration of the gut microbiota in Chinese population with chronic kidney disease [2017] [Scientific Reports] [Journal] [80000616]
[1.5] Dysbiosis of the gut microbiome is associated with CKD5 and correlated with clinical indices of the disease: a case-controlled study [2019] [Journal of Translational Medicine] [Journal] [80001101]
[1.6] Gut microbiota composition and frailty in elderly patients with Chronic Kidney Disease [2020] [PLOS ONE] [Journal] [80001402]
[1.7] Altered gut microbiota and microbial biomarkers associated with chronic kidney disease [2018] [MicrobiologyOpen] [Journal] [80000867]
[1.8] Microbiome in Chronic Kidney Disease (CKD): An Omics Perspective [2022] [Review] [Toxins] [Journal] [80002388]
[1.9] Isolation and quantification of uremic toxin precursor-generating gut bacteria in chronic kidney disease patients [2020] [International journal of molecular sciences] [Journal] [80001379]
[1.10] Characterizing the gut microbiota in patients with chronic kidney disease [2020] [Abstract] [Postgraduate Medicine] [Journal] [80001316]
[1.11] A reduction in the butyrate producing species Roseburia spp. and Faecalibacterium prausnitzii is associated with chronic kidney disease progression [2016] [Antonie van Leeuwenhoek (2016)] [Journal] [80000548]
[1.12] Curcumin Supplementation (Meriva®) Modulates Inflammation, Lipid Peroxidation and Gut Microbiota Composition in Chronic Kidney Disease [2022] [Research] [Nutrients] [Journal] [80002204]
[1.13] Intestinal microbiota and diabetic kidney diseases: role of microbiota and derived metabolites in the modulation of renal inflammation and disease progression [2021] [Review] [ScienceDirect] [Journal] [80001512]
[1.14] The interplay between host genetics and the gut microbiome reveals common and distinct microbiome features for complex human diseases [2020] [Review] [Microbiome] [Journal] [80000204]
[1.15] Gut Microbiota and Their Derived Metabolites, a Search for Potential Targets to Limit Accumulation of Protein-Bound Uremic Toxins in Chronic Kidney Disease [2021] [Research] [Toxins] [Journal] [80002131]
[1.16] Small molecules in the big picture of gut microbiome-host cross-talk - IMPORTANT [2022] [Review] [EBioMedicine] [Journal] [80002422]

Disease ⇒ Chronic kidney disease {40000186}

Record Keys

Details

Meta Information

Notes:

References Notes

Shared Reference Notes

Common References