Disease ⇒ Chronic kidney disease {40000186}
Type: | Disease |
---|---|
Parent: | [ ] |
Definition: | Chronic kidney disease |
Initialisation date: | 2020-10-13 |
---|---|
Other Terms: | CKD |
MedDra ID: | 10064848 |
---|---|
MedDra Level: | pt |
ICD: | [ ] |
Zone: | [ ] |
Mechanism: | [ ] |
Notes:
[ ]
Shared Reference Notes
- [1.1]
- In chronic kidney disease (CKD), the “healthy” microbiota structure is disrupted, and intestinal microbes produce large quantities of uremic solutes responsible for renal damage; on the other hand, the uremic state, fueled by reduced renal clearance, causes shifts in microbial metabolism and composition, hence creating a vicious cycle in which dysbiosis and renal dysfunction are progressively worsened. - [1.2]
- Saccharibacteria (per 1-SD higher in the log-transformed abundance) could potentially decrease the concentration of serum creatinine and increase the estimated glomerular filtration rate which might help improve renal function. - [1.3] [#Uremic toxins]
- [1.4]
- #Curcumin > significantly reduced plasma pro-inflammatory mediators (CCL-2, IFN-γ, and IL-4) and lipid peroxidation. - After 6 months of #Curcumin supplementation > significantly lower #Escherichia-#Shigella and significantly higher #Lachnoclostridium . - In the last 3 months of supplementation > significantly higher #Lactobacillaceae spp.. - [1.5]
- Bacterial species involved in #Butyrate production, #Indole synthesis and mucin degradation were also related to CKD. - [1.6]
- Chronic kidney disease > decreased #Indole, #Indole-3-carboxaldehyde and #Indole-3-propionic acid - [1.7] [#Aging]
- #Hippuric acid has been found increased in patients with chronic kidney disease and several age-related conditions - [1.8]
- [1.9]
- #Hydrogen sulfide (H2S) and methanethiol are produced during the decomposition of #Sulfur-containing amino acids, and have been linked to the progression of chronic kidney disease (CKD), cardiovascular disease, and bone metabolic disorders
References Notes
[ ]