Disease ⇒ Fibrosis {40000517}

Shared Reference Notes

• [1.1] [#Lactobacillus paracasei] 
  - The fibrosis-triggering microbial populations in the cecum as mucolytic bacteria : the species #Mucispirillum schaedleri, the genus #Ruminococcus, and the genus #Anaeroplasma, and in the ileum, such as the genera #Streptococcus and Lactobacillus.
• - Members of the genera #Oscillospira and #Coprococcus in the cecum, as well as #Faecalibacterium prausnitzii and members of the genus #Bacteroides in the ileum > negatively correlated with fibrosis.
• [1.2] 
• [1.3] [#CVD] [#Exercise training, #Western-style diet] 
  - voluntary exercise curbs #TMAO elevation and decreases myocardial inflammation and fibrosis, leading to the prevention of cardiac dysfunction in western diet-induced #Obesity
• [1.4] 
  - #IL-17A has been found to be associated with neurological sequelae and pulmonary fibrosis in post-#Covid-19 patients
• - Elevated blood levels of hydroxyproline have been proposed as a biomarker for diseases characterized by fibrosis, indicating an increased demand for #Proline in collagen synthesis.
• [1.5] 
  - #Sulforaphane is a naturally occurring, potent antioxidant, found in Brassicaceae plants such as #Broccoli, and is being considered for use in the treatment of fibrosis, #Cancer and preeclampsia
• [1.6] [#End-stage renal disease] 
  - #Nitrate treatment boosted the #Nitrate-nitrite-NO pathway, which ameliorated UUO-induced renal dysfunction and fibrosis in mice, represented by improved glomerular filtration and morphological structure and decreased renal collagen deposition, pro-fibrotic marker expression, and inflammation.
• [1.7] [#Liver fibrosis, #Metabolic associated fatty liver disease] 
  - supplementation with #Lachnospiraceae and #Ruminococcaceae can protect against obesity, inflammation, intestinal dysbiosis, and hepatic fibrosis in MASLD
• [1.8] [#Metabolic associated fatty liver disease] [#Lactobacillus bulgaricus, #Lactobacillus paracasei, #Lactobacillus plantarum] 
  - Randomized controlled trials in NAFLD patients revealed that administration of polymicrobial probiotics (containing #Bifidobacteria, #Lactobacillus acidophilus, L. bulgaricus, L. paracasei, L. plantarum, and #Streptococcus thermophilus) significantly reduced the fatty liver phenotype, inflammation, and fibrosis.
• [1.9] [#Chronic kidney disease] 
  - #TMAO causes kidney injury and tubulointerstitial fibrosis. - Higher #TMAO levels associated with higher risk of incident CKD and greater annualized eGFR decline, and with monotonic dose-response relationships.
• [#Chronic kidney disease] - #TMAO was also able to significantly induce #IL-6 release alone from renal fibroblast, strengthening the link to renal fibrosis.
• [#Chronic kidney disease] [#TNF-alfa] - combined exposure of #TMAO and TNF-α can increase fibronectin release from renal fibroblasts. - Several studies indicate that #TMAO exacerbates tubulointerstitial fibrosis and renal inflammation in CKD. - neither #TMAO nor TNF-α alone increased fibronectin release from renal fibroblasts. - #TMAO and TNF-α alone or in combination increased total collagen production. - the combination of #TMAO and TNF-α can increase fibronectin release compared to TNF-α alone. - Fibronectin, a high molecular weight glycoprotein with adhesive properties, holds a pivotal function in both wound-healing processes and the formation of extracellular matrix - TNF-α and #TMAO induced increased fibroblast proliferation and that the combination of TNF-α 1 ng/ml and #TMAO induced increased cell proliferation compared to TNF-α alone. - both #TMAO and TNF-α mediate their proliferative and collagen inducing effects on renal fibroblast via Akt, mTOR and ERK, but not PI3K.
• [1.11] [#Cirrhosis, #Metabolic associated fatty liver disease] 
  - in MAFLD > Microbiome composition was unique in patients with advanced fibrosis, who had enriched levels of #Prevotella copri, the most predictive microbiome in the classifier.

References Notes