[1.1] [#Systemic lupus erythematosus] - Many Lupus patients have little or no detectable perturbations in representation of the Lachnospiraceae family or abundance of #Ruminococcus gnavus species overtime.
[1.2] [#Crohn’s disease] [#Escherichia coli] [#Fecal Microbiota Transplantation] - Comprehensive overview of functional dysbiosis in the gut microbiome during IBD activity showed increases in facultative anaerobes, such as E. coli which correlates with inflammation status, and decreases in obligate anaerobes, such as #Faecalibacterium prausnitzii and #Roseburia hominis
-The results of the present study confirmed decreases in the abundance of Firmicutes and Bacteroidetes, increases in Enterobacteriaceae, Pasteurellaceae, and Veillonellaceae and the presence of Fusobacterium in stool samples of CD patients.
- #Butyrate-producing bacteria are depleted in IBD patients, and probiotic treatment with these bacteria has therapeutic potential.
- A higher proportion of Lachnospiraceae in donor stool was associated with a higher success rate of FMT, and recipients that responded to FMT exhibited increases in #Butyrate-producing Lachnospiraceae and Ruminococcaceae.
- The reduced SCFA levels in patients with IBD result from lower abundance of SCFA-producing bacteria, especially those of the phylum Firmicutes.
-- #Butyrate can act as an energy source for normal colon epithelial cells, promoting their proliferation, but can also inhibit proliferation and induce apoptosis.
[1.3] - Blautia, Coprococcus, Dorea, Lachnospira, Oribacterium, Roseburia, and L-Ruminococcus (Ruminococcus genus assigned to the Lachnospiraceae family) are the main genera that have been detected in the human intestine by metagenomics analyses. - All members of Lachnospiraceae are anaerobic, fermentative, and chemoorganotrophic, and some display strong hydrolyzing activities, through the activity of pectin methyl-esterase, pectate lyase, xylanase, α-L-arabinofuranosidase, β-xylosidase α- and β-galactosidase, α- and β-glucosidase, N-acetyl-β-glucosaminidase, or α-amylase.
- Lachnospiraceae are present in early infants, found even in the meconium.
- increases in Lachnospiraceae abundances are associated with aging.
- Lachnospiraceae abundance also increases in the intestinal lumen of subjects with different diseases, although the taxa of this family have repeatedly shown their ability to produce beneficial metabolites for the host.
[1.4] - Different genera of Lachnospiraceae were negatively associated with body fat, LDL and total cholesterol.
- Lachnospiraceae is associated with lipid cardiovascular risk factors.
[1.5] - Dietary fiber, magnesium, and potassium > inversely abundance of Lachnospiraceae
[1.7] [#Parkinson’s Disease] - Decreased Lachnospiraceae > reduction in anti-inflammatory and neuroprotective metabolite in PD
Increased Bacteroides and Verrucomicrobia > Metabolites correlated positively with the frequency of the proinflammatory cytokines TNF-α and IFN-γ
[1.9] - 4 weeks of #Grape powder consumption > significantly increased the alpha diversity index of the gut microbiome > increasing #Verrucomicrobia at the phylum level, and a significant increase in #Akkermansia and increase in #Flavonifractor and Lachnospiraceae_UCG-010 > decrease in #Bifidobacterium and #Dialister at the genus level.
[#Gastric carcinoma] - #Aquabacterium, #Streptococcus and Lachnospiraceae > predict gastric cancer.
- patients with low levels of #Streptococcus and Lachnospiraceae > more likely to live with gastric cancer without it getting worse.
- Patient > more bacterial genes involved in the breakdown of #D-galacturonate > play a key role in the development of gastric cancer
[1.13] [#Cognitive impairment] - #Barnesiella was positively associated with the first principal component, DSST, and category fluency;
- Lachnospiraceae FCS020 group was positively associated with DSST.
- #Sutterella was negatively associated with MoCA
[1.14] [#Amyotrophic lateral sclerosis] - ALS in mice> altered bacterial community related to autoimmunity (e.g., #Clostridium sp. ASF502, Lachnospiraceae bacterium A4), inflammation (e.g., #Enterohabdus Muris,), and metabolism (e.g., #Desulfovibrio fairfieldensis) at 1- and 2-month-old SOD1G93A mice, suggesting the early microbial contribution to the pathological changes.
[1.15] [#Heart failure] [#Eubacterium hallii, #Ruminococcaceae] - patients with HF have a decrease in #Butyrate-producing bacteria, especially, Lachnospiracea and Ruminococcacea families.
- reduction of the #Butyrate-producing Eubacterium Halli and Lachnospiracea is correlated with increased inflammation, severity of disease, heart damage and mortality
- bacteria with capacity of butyrate production, Lachnospiraceae and #Ruminococcaceae, were depleted in individuals at a high risk of #Stroke. Fecal butyrate concentrations also were low in these people
[1.17] [#Inflamatory bowel disease, #Systemic anti-microbiota IgG] - a modified high-throughput, culture-independent approach to quantify systemic IgG against gut commensal bacteria in human serum samples without the need for paired stool samples.
- Using this approach, we highlight several commensal bacterial species that elicit elevated IgG responses in patients with inflammatory bowel disease (IBD) including taxa within the clades #Collinsella, #Bifidobacterium, Lachnospiraceae, and #Ruminococcaceae.
[1.18] [#Multiple Sclerosis] - Faecalibacteria, Lachnospiraceae, and #Anaerostipes produce butyrate, which acts via G-protein coupled receptors activation and histone deacetylase inhibition to suppress CNS demyelination, the main pathological feature in MS.
[1.19] [#Rheumatoid Arthritis] -IgG and IgA autoantibodies from individuals who are at risk for RA cross-react against gut bacteria in the Lachnospiraceae and #Ruminococcaceae families.
- Analysis identified a bacterial strain from the #Subdoligranulum genus that was associated with autoantibody development.
- Mice colonized with this #Subdoligranulum isolate developed arthritis with pathology similar to human RA.
[1.22] [#Rheumatoid Arthritis] - IgG and IgA autoantibodies from individuals who are at risk for RA cross-react against gut bacteria in the Lachnospiraceae and #Ruminococcaceae families.
- RA > a bacterial strain from the Subdoligranulum genus (#Subdoligranulum didolesgii) that was associated with autoantibody development.
[1.23] [#Butyrate] - the Lachnospiraceae family of anaerobic bacteria increased during #Fasting.
- This family, in the order Clostridiales, promotes butryogenesis in the gut, a process that is associated with healthful metabolic and prolongevity effects.
[1.26] [#Plastics] - tea bags-treated mice were proved an increase in Lachnospiraceae and a decreased in #Muribaculaceae in gut
[1.27] - #Fasting > increased microbiome diversity and was specifically associated with upregulation of the #Clostridiales order–derived Lachnospiraceae and #Ruminococcaceae bacterial families.
- increased Lachnospiraceae > #Butyrate
[1.28] - the gut microbiome signatures associated with the markers of cellular senescence and inflammatory factors, known as senescence-associated secretory phenotype (SASP) were evaluated. Findings revealed that #Clostridiales, #Staphylococcus, and Lachnospiraceae positively correlated with all of the cellular senescence and inflammatory markers.
[1.29] [#Diabetes Type 2] Diabetes :
- The gut–brain–beta cell glucagon-like peptide-1 (GLP-1)-dependent axis and the clock genes both control insulin secretion.
- GLP-1sensitivity is maximal during the dark feeding period, i.e., the postprandial state.
- The abundance of ileum bacteria, particularly #Ruminococcaceae and Lachnospiraceae, oscillated diurnally, with a maximum during the dark period, along with expression patterns of a subset of clock genes.
- This diurnal pattern of circadian gene expression and Lachnospiraceae abundance was also observed in two separate mouse models of gut microbiota dysbiosis and of autonomic neuropathy with impaired GLP-1 sensitivity.
[#Cannabidiol] - CBD treatment increased the abundance of beneficial bacteria, which include Lachnospiraceae_NK4A136 and #Blautia in the gut.
[1.33] [#Amyloid-beta] - In the mice study, the increased abundance of Lachnospiraceae family was associated with reduced deposition of β #Amyloid in brain tissue
