Microbiome & Chronic Diseases

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Lachnospiraceae ⇒ Clostridiales {10000240}

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- Short chain fatty acid producer

References Notes

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Shared Reference Notes

  • [1.90
    - Blautia, Coprococcus, Dorea, Lachnospira, Oribacterium, Roseburia, and L-Ruminococcus (Ruminococcus genus assigned to the Lachnospiraceae family) are the main genera that have been detected in the human intestine by metagenomics analyses. - All members of Lachnospiraceae are anaerobic, fermentative, and chemoorganotrophic, and some display strong hydrolyzing activities, through the activity of pectin methyl-esterase, pectate lyase, xylanase, α-L-arabinofuranosidase, β-xylosidase α- and β-galactosidase, α- and β-glucosidase, N-acetyl-β-glucosaminidase, or α-amylase. - Lachnospiraceae are present in early infants, found even in the meconium. - increases in Lachnospiraceae abundances are associated with aging. - Lachnospiraceae abundance also increases in the intestinal lumen of subjects with different diseases, although the taxa of this family have repeatedly shown their ability to produce beneficial metabolites for the host.
  • [1.91
    - Different genera of Lachnospiraceae were negatively associated with body fat, LDL and total cholesterol. - Lachnospiraceae is associated with lipid cardiovascular risk factors.
  • [1.92
    - Dietary fiber, magnesium, and potassium > inversely abundance of Lachnospiraceae
  • [#Maternal consumption of dietary fibre] - Higher maternal consumption of dietary fiber > infant > Lower Lachnospiraceae count.
  • [1.93] [#Parkinson’s Disease
    - Decreased Lachnospiraceae > reduction in anti-inflammatory and neuroprotective metabolite in PD Increased Bacteroides and Verrucomicrobia > Metabolites correlated positively with the frequency of the proinflammatory cytokines TNF-α and IFN-γ
  • [1.89
    - #Protein powder consumption > decrease in Lachnospiraceae, #Roseburia, #Blautia, Synergistales, #Coprococcus, #Lactobacillales, Bacilli, #Bifidobacterium longum and #Firmicutes. - #Protein powder consumption > higher abundance of #Bacteroidetes.
  • [1.94
    - 4 weeks of #Grape powder consumption > significantly increased the alpha diversity index of the gut microbiome > increasing #Verrucomicrobia at the phylum level, and a significant increase in #Akkermansia and increase in #Flavonifractor and Lachnospiraceae_UCG-010 > decrease in #Bifidobacterium and #Dialister at the genus level.
  • [1.16] [#Gastric carcinoma
    - #Aquabacterium, #Streptococcus and Lachnospiraceae > predict gastric cancer. - patients with low levels of #Streptococcus and Lachnospiraceae > more likely to live with gastric cancer without it getting worse. - Patient > more bacterial genes involved in the breakdown of #D-galacturonate > play a key role in the development of gastric cancer
  • [1.82] [#Psychogenic erectile dysfunction
    - Erectile dysfunction > no #Alloprevotella . - Erectile dysfunction > increased #Streptococci and #Subdoligranulum - Erectile dysfunction > decreased #Prevotella sp.9, #Blautia, Lachnospiraceae NK4A136 groups and #Roseburia.
  • [1.66] [#Infectious diarrhea
    - A drastic disappearance of obligate anaerobic gut commensals (#Blautia, #Prevotella, #Faecalibacterium, Lachnospiraceae, #Ruminococcaceae, etc.), leading to a depletion of associated metabolites such as #Short Chain Fatty Acid (SCFAs)
  • [1.10] [#Cognitive impairment
    - #Barnesiella was positively associated with the first principal component, DSST, and category fluency; - Lachnospiraceae FCS020 group was positively associated with DSST. - #Sutterella was negatively associated with MoCA
  • [1.95] [#Amyotrophic lateral sclerosis
    - ALS in mice> altered bacterial community related to autoimmunity (e.g., #Clostridium sp. ASF502, Lachnospiraceae bacterium A4), inflammation (e.g., #Enterohabdus Muris,), and metabolism (e.g., #Desulfovibrio fairfieldensis) at 1- and 2-month-old SOD1G93A mice, suggesting the early microbial contribution to the pathological changes.
  • [1.68] [#Heart failure] [#Eubacterium hallii, #Ruminococcaceae
    - patients with HF have a decrease in #Butyrate-producing bacteria, especially, Lachnospiracea and Ruminococcacea families. - reduction of the #Butyrate-producing Eubacterium Halli and Lachnospiracea is correlated with increased inflammation, severity of disease, heart damage and mortality
  • [#Ischemic stroke] - bacteria with capacity of butyrate production, Lachnospiraceae and #Ruminococcaceae, were depleted in individuals at a high risk of stroke. Fecal butyrate concentrations also were low in these people
  • [1.78] [#Parkinson’s Disease
    - #Prevotellaceae (Prevotella), #Ruminococcaceae (#Faecalibacterium), Lachnospiraceae (#Blautia, #Roseburia) that produce SCFA and help in the synthesis of mucin to maintain the intestinal integrity are considerably lower in abundance in PD
  • [1.96] [#Inflamatory bowel disease, #Systemic anti-microbiota IgG
    - a modified high-throughput, culture-independent approach to quantify systemic IgG against gut commensal bacteria in human serum samples without the need for paired stool samples. - Using this approach, we highlight several commensal bacterial species that elicit elevated IgG responses in patients with inflammatory bowel disease (IBD) including taxa within the clades #Collinsella, #Bifidobacterium, Lachnospiraceae, and #Ruminococcaceae.
  • [1.97] [#Multiple Sclerosis
    - Faecalibacteria, Lachnospiraceae, and #Anaerostipes produce butyrate, which acts via G-protein coupled receptors activation and histone deacetylase inhibition to suppress CNS demyelination, the main pathological feature in MS.
  • [1.98] [#Rheumatoid Arthritis
    -IgG and IgA autoantibodies from individuals who are at risk for RA cross-react against gut bacteria in the Lachnospiraceae and #Ruminococcaceae families. - Analysis identified a bacterial strain from the #Subdoligranulum genus that was associated with autoantibody development. - Mice colonized with this #Subdoligranulum isolate developed arthritis with pathology similar to human RA.

Common References