Microbiome & Chronic Diseases

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Lachnospiraceae ⇒ Clostridiales {10000240}

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- Short chain fatty acid producer

References Notes

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Shared Reference Notes

  • [1.86
    - Blautia, Coprococcus, Dorea, Lachnospira, Oribacterium, Roseburia, and L-Ruminococcus (Ruminococcus genus assigned to the Lachnospiraceae family) are the main genera that have been detected in the human intestine by metagenomics analyses. - All members of Lachnospiraceae are anaerobic, fermentative, and chemoorganotrophic, and some display strong hydrolyzing activities, through the activity of pectin methyl-esterase, pectate lyase, xylanase, α-L-arabinofuranosidase, β-xylosidase α- and β-galactosidase, α- and β-glucosidase, N-acetyl-β-glucosaminidase, or α-amylase.
    - Lachnospiraceae are present in early infants, found even in the meconium.
    - increases in Lachnospiraceae abundances are associated with aging.
    - Lachnospiraceae abundance also increases in the intestinal lumen of subjects with different diseases, although the taxa of this family have repeatedly shown their ability to produce beneficial metabolites for the host.
  • [1.87
    - Different genera of Lachnospiraceae were negatively associated with body fat, LDL and total cholesterol.
    - Lachnospiraceae is associated with lipid cardiovascular risk factors.
  • [1.88
    - Higher maternal consumption of dietary fiber > infant > Lower Lachnospiraceae count.
  • - Dietary fiber, magnesium, and potassium > inversely abundance of Lachnospiraceae
  • [1.89
    - Decreased Lachnospiraceae > reduction in anti-inflammatory and neuroprotective metabolite in PD
    Increased Bacteroides and Verrucomicrobia > Metabolites correlated positively with the frequency of the proinflammatory cytokines TNF-α and IFN-γ
  • [1.90
    - Protein powder consumption > decrease in Lachnospiraceae, Roseburia, Blautia, Synergistales, Coprococcus, Lactobacillales, Bacilli, Bifidobacterium longum and Firmicutes.
    - Protein powder consumption > higher abundance of Bacteroidetes.
  • [1.91
    - 4 weeks of grape powder consumption > significantly increased the alpha diversity index of the gut microbiome > increasing Verrucomicrobia at the phylum level, and a significant increase in Akkermansia and increase in Flavonifractor and Lachnospiraceae_UCG-010 > decrease in Bifidobacterium and Dialister at the genus level.
  • [1.16
    - Aquabacterium, Streptococcus and Lachnospiraceae > predict gastric cancer.
    - patients with low levels of Streptococcus and Lachnospiraceae > more likely to live with gastric cancer without it getting worse.
    - Patient > more bacterial genes involved in the breakdown of D-galacturonate > play a key role in the development of gastric cancer
  • [1.82
    - Erectile dysfunction > no Alloprevotella .
    - Erectile dysfunction > increased streptococci and Subdoligranulum
    - Erectile dysfunction > decreased Prevotella sp.9, Blautia, Lachnospiraceae NK4A136 groups and Roseburia.
  • [1.66
    - A drastic disappearance of obligate anaerobic gut commensals (Blautia, Prevotella, Faecalibacterium, Lachnospiraceae, Ruminococcaceae, etc.), leading to a depletion of associated metabolites such as short chain fatty acid (SCFAs)
  • [1.10
    - Barnesiella was positively associated with the first principal component, DSST, and category fluency;
    - Lachnospiraceae FCS020 group was positively associated with DSST.
    - Sutterella was negatively associated with MoCA
  • [1.92
    - ALS in mice> altered bacterial community related to autoimmunity (e.g., Clostridium sp. ASF502, Lachnospiraceae bacterium A4), inflammation (e.g., Enterohabdus Muris,), and metabolism (e.g., Desulfovibrio fairfieldensis) at 1- and 2-month-old SOD1G93A mice, suggesting the early microbial contribution to the pathological changes.
  • [1.68
    - bacteria with capacity of butyrate production, Lachnospiraceae and Ruminococcaceae, were depleted in individuals at a high risk of stroke. Fecal butyrate concentrations also were low in these people
  • - patients with HF have a decrease in butyrate-producing bacteria, especially, Lachnospiracea and Ruminococcacea families.
    - reduction of the butyrate-producing Eubacterium Halli and Lachnospiracea is correlated with increased inflammation, severity of disease, heart damage and mortality
  • [1.78
    - Prevotellaceae (Prevotella), Ruminococcaceae (Faecalibacterium), Lachnospiraceae (Blautia, Roseburia) that produce SCFA and help in the synthesis of mucin to maintain the intestinal integrity are considerably lower in abundance in PD

Common References