Microbiota ☳
Lachnospiraceae ⇒ Clostridiales {10000240}
Record Keys
Organism: Lachnospiraceae
Parent:
Details
Initialisation date: 2020-09-22
Meta Information
Rank:
Domain:
Zone: [ ]
Enzyme: [ ]
Function: [ ]
Notes:
- Short chain fatty acid producer
Shared Reference Notes [1.86 ] - Blautia, Coprococcus, Dorea, Lachnospira, Oribacterium, Roseburia, and L-Ruminococcus (Ruminococcus genus assigned to the Lachnospiraceae family) are the main genera that have been detected in the human intestine by metagenomics analyses. - All members of Lachnospiraceae are anaerobic, fermentative, and chemoorganotrophic, and some display strong hydrolyzing activities, through the activity of pectin methyl-esterase, pectate lyase, xylanase, α-L-arabinofuranosidase, β-xylosidase α- and β-galactosidase, α- and β-glucosidase, N-acetyl-β-glucosaminidase, or α-amylase.
- Lachnospiraceae are present in early infants, found even in the meconium.
- increases in Lachnospiraceae abundances are associated with aging.
- Lachnospiraceae abundance also increases in the intestinal lumen of subjects with different diseases, although the taxa of this family have repeatedly shown their ability to produce beneficial metabolites for the host. [1.87 ] - Different genera of Lachnospiraceae were negatively associated with body fat, LDL and total cholesterol.
- Lachnospiraceae is associated with lipid cardiovascular risk factors. [1.88 ] - Higher maternal consumption of dietary fiber > infant > Lower Lachnospiraceae count. - Dietary fiber, magnesium, and potassium > inversely abundance of Lachnospiraceae [1.89 ] - Decreased Lachnospiraceae > reduction in anti-inflammatory and neuroprotective metabolite in PD
Increased Bacteroides and Verrucomicrobia > Metabolites correlated positively with the frequency of the proinflammatory cytokines TNF-α and IFN-γ [1.90 ] - Protein powder consumption > decrease in Lachnospiraceae , Roseburia, Blautia, Synergistales, Coprococcus, Lactobacillales, Bacilli, Bifidobacterium longum and Firmicutes.
- Protein powder consumption > higher abundance of Bacteroidetes. [1.91 ] - 4 weeks of grape powder consumption > significantly increased the alpha diversity index of the gut microbiome > increasing Verrucomicrobia at the phylum level, and a significant increase in Akkermansia and increase in Flavonifractor and Lachnospiraceae _UCG-010 > decrease in Bifidobacterium and Dialister at the genus level. [1.16 ] - Aquabacterium, Streptococcus and Lachnospiraceae > predict gastric cancer.
- patients with low levels of Streptococcus and Lachnospiraceae > more likely to live with gastric cancer without it getting worse.
- Patient > more bacterial genes involved in the breakdown of D-galacturonate > play a key role in the development of gastric cancer [1.82 ] - Erectile dysfunction > no Alloprevotella .
- Erectile dysfunction > increased streptococci and Subdoligranulum
- Erectile dysfunction > decreased Prevotella sp.9, Blautia, Lachnospiraceae NK4A136 groups and Roseburia. [1.66 ] - A drastic disappearance of obligate anaerobic gut commensals (Blautia, Prevotella, Faecalibacterium, Lachnospiraceae , Ruminococcaceae, etc.), leading to a depletion of associated metabolites such as short chain fatty acid (SCFAs) [1.10 ] - Barnesiella was positively associated with the first principal component, DSST, and category fluency;
- Lachnospiraceae FCS020 group was positively associated with DSST.
- Sutterella was negatively associated with MoCA [1.92 ] - ALS in mice> altered bacterial community related to autoimmunity (e.g., Clostridium sp. ASF502, Lachnospiraceae bacterium A4), inflammation (e.g., Enterohabdus Muris,), and metabolism (e.g., Desulfovibrio fairfieldensis) at 1- and 2-month-old SOD1G93A mice, suggesting the early microbial contribution to the pathological changes. [1.68 ] - bacteria with capacity of butyrate production, Lachnospiraceae and Ruminococcaceae, were depleted in individuals at a high risk of stroke. Fecal butyrate concentrations also were low in these people - patients with HF have a decrease in butyrate-producing bacteria, especially, Lachnospiracea and Ruminococcacea families.
- reduction of the butyrate-producing Eubacterium Halli and Lachnospiracea is correlated with increased inflammation, severity of disease, heart damage and mortality [1.78 ] - Prevotellaceae (Prevotella), Ruminococcaceae (Faecalibacterium), Lachnospiraceae (Blautia, Roseburia) that produce SCFA and help in the synthesis of mucin to maintain the intestinal integrity are considerably lower in abundance in PD
Common References
[1.1 ] Characterization of gut microbiota composition and functions in patients with chronic alcohol overconsumption [2019] [Gut microbes] [Journal] [80001029 ]
[1.2 ] Analysis of the gut microbiota in alopecia areata: identification of bacterial biomarkers [2019] [Journal of the European Academy of Dermatology and Venereology] [Journal] [80001236 ]
[1.3 ] Evaluation of the microbial diversity in amyotrophic lateral sclerosis using high-throughput sequencing [2016] [Frontiers in Microbiology] [Journal] [80001142 ]
[1.4 ] Intestinal dysbiosis in Ankylosing Spondylitis [2015] [Arthritis & Rheumatology] [Journal] [80000328 ]
[1.5 ] Altered gut microbiota in Chinese children with autism spectrum disorders [2019] [Frontiers in Cellular and Infection Microbiology] [Journal] [80000976 ]
[1.6 ] Molecular assessment of bacterial vaginosis by Lactobacillus abundance and species diversity [2016] [BMC Infectious Diseases] [Journal] [80000638 ]
[1.7 ] Amplicon-based microbiome study highlights the loss of diversity and the establishment of a set of species in patients with dentin caries [2019] [PLOS ONE] [Journal] [80001211 ]
[1.8 ] Salivary microbiota and metabolome associated with celiac disease [2014] [Applied and Environmental Microbiology] [Journal] [80000528 ]
[1.9 ] Alterations of Bacteroides sp., Neisseria sp., Actinomyces sp., and Streptococcus sp. populations in the oropharyngeal microbiome are associated with liver cirrhosis and pneumonia. [2015] [BMC Infectious Diseases] [Journal] [80000609 ]
[1.10 ] Association of the Gut Microbiota With Cognitive Function in Midlife [2022] [Study] [JAMA Network Open] [Journal] [80002335 ]
[1.11 ] The gut microbiota in collagenous colitis shares characteristics with inflammatory bowel diseas-associated dysbiosis [2019] [Clinical and Translational Gastroenterology] [Journal] [80001117 ]
[1.12 ] Colinic mucosa-associated microbiota is influenced by an interaction of Crohn disease and FUT2 (Secretor) genotype [2011] [PNAS] [Journal] [80001200 ]
[1.13 ] Disrupted progression of the intestinal microbiota with age in children with cystic fibrosis [2016] [Scientific Reports] [Journal] [80000388 ]
[1.14 ] A metagenome-wide association study of gut microbiota in type 2 diabetes. [2012] [Nature] [Journal] [80000240 ]
[1.15 ] Specific changes in faecal microbiota are associated with familial mediterranean fever [2019] [Annals of the Rheumatic Diseases] [Journal] [80001097 ]
[1.16 ] Fecal Streptococcus Alteration Is Associated with Gastric Cancer Occurrence and Liver Metastasis [2021] [Study] [mBio] [Journal] [80002252 ]
[1.17 ] Alterations in gut microbiota of gestational diabetes patients during the first trimester of pregnancy [2020] [Frontiers in Cellular and Infection Microbiology] [Journal] [80001364 ]
[1.18 ] Gut Microbiome Signatures in the Progression of Hepatitis B Virus-Induced Liver Disease [2022] [Study] [Frontiers in Microbiology] [Journal] [80002427 ]
[1.19 ] Deep sequencing reveals microbiota dysbiosis of tongue coat in patients with liver carcinoma [2016] [Scientific Reports] [Journal] [80001032 ]
[1.20 ] 16S rRNA gene sequencing reveals altered composition of gut microbiota in individuals with kidney stones [2018] [Urolithiasis] [Journal] [80000675 ]
[1.21 ] Specific gut microbiome signature predicts the early-stage lung cancer [2020] [Gut microbes] [Journal] [80001413 ]
[1.22 ] Proinflammatory sulfur-reducing bacteria are more abundant in colonic biopsies of patients with microscopic colitis compared to healthy controls [2018] [Digestive Diseases and Sciences] [Journal] [80000870 ]
[1.23 ] Structural and functional characterization of the gut microbiota in elderly women with migraine [2020] [Frontiers in Cellular and Infection Microbiology] [Journal] [80001365 ]
[1.24 ] Bile acids associate with specific gut microbiota, low-level alcohol consumption and liver fibrosis in patients with non-alcoholic fatty liver disease [2020] [Liver International] [Journal] [80001417 ]
[1.25 ] Oral microbial community composition is associated with pancreatic cancer: a case-control study in Iran [2020] [Cancer Medicine] [Journal] [80001273 ]
[1.26 ] Gut microbiota differs between parkinson's disease patients and healthy controls in northeast China [2019] [Frontiers in Molecular Neuroscience] [Journal] [80001147 ]
[1.27 ] The gut-adherent microbiota of PSC-IBD is distinct to that of IBD [2017] [Gut] [Journal] [80000518 ]
[1.28 ] Dysbiosis of gut microbiota was closely associated with psoriasis [2019] [Science China Life Sciences] [Journal] [80001218 ]
[1.29 ] Alterations in the gut microbiota of patients with silica-induced pulmonary fibrosis [2019] [Journal of Occupational Medicine and Toxicology] [Journal] [80000939 ]
[1.30 ] Dialister as a microbial marker of disease activity in Spondyloarthritis [2017] [Arthritis & Rheumatology] [Journal] [80000453 ]
[1.31 ] Subgingival microbiota dysbiosis in systemic lupus erythematosus: association with periodontal status. [2017] [Microbiome] [Journal] [80000454 ]
[1.32 ] Defining dysbiosis in patients with urolithiasis_DUBLICATE [2019] [Scientific Reports] [Journal] [80000950 ]
[1.33 ] Subgingival dysbiosis in smoker and non-smoker patients with chronic periodontitis [2017] [Molecular Medicine Reports] [Journal] [80000444 ]
[1.34 ] Drinking alcohol is associated with variation in the human oral microbiome in a large study of american adults [2018] [Microbiome] [Journal] [80000944 ]
[1.35 ] Altered microbiomes distinguish Alzheimer's disease from amnestic mild cognitive impairment and health in a Chinese cohort [2019] [Brain, Behavior, and Immunity] [Journal] [80001073 ]
[1.36 ] Distinctive subpopulations of the intestinal microbiota are present in women with unexplained chronic anovulation [2019] [Reproductive Biomedicine online] [Journal] [80000927 ]
[1.37 ] Helicobacter pylori infection aggravates dysbiosis of gut microbiome in children with gastritis [2019] [Frontiers in Cellular and Infection Microbiology] [Journal] [80001277 ]
[1.38 ] Case-Control study of the effects of gut microbiota composition on neurotransmitter metabolic pathways in children with attention deficit hyperactivity disorder [2020] [Frontiers in Neuroscience] [Journal] [80001372 ]
[1.39 ] Alterations of oral microbiota distinguish children with autism spectrum disorders from healthy controls [2018] [Scientific Reports] [Journal] [80000691 ]
[1.40 ] Altered gut microbiota and short chain fatty acids in Chinese children with autism spectrum disorder [2019] [Scientific Reports] [Journal] [80000947 ]
[1.41 ] Oral microbiota in autoimmune polyendocrine syndrome type 1 [2018] [Journal of Oral Microbiology] [Journal] [80000749 ]
[1.42 ] Sequencing of 16S rRNA reveals a distinct salivary microbiome signature in Behcet's disease [2016] [Clinical Immunology] [Journal] [80000770 ]
[1.43 ] Extensive description and comparison of human supra-gingival microbiome in root caries and health. [2015] [PLOS ONE] [Journal] [80000363 ]
[1.44 ] Duodenal mucosa of patients with type 1 diabetes shows distinctive inflammatory profile and microbiota [2017] [The Journal of Clinical Endocrinology & Metabolism] [Journal] [80000520 ]
[1.45 ] Altered diversity and composition of gut microbiota in Chinese patients with chronic pancreatitis [2019] [Pancreatology] [Journal] [80001241 ]
[1.46 ] Impact of cigarette smoking on the middle meatus microbiome in health and chronic rhinosinusitis [2015] [International forum of allergy & rhinology] [Journal] [80000887 ]
[1.47 ] Altered profile of human gut microbiome is associated with cirrhosis and its complications [2014] [Journal of Hepatology] [Journal] [80000281 ]
[1.48 ] The human gut microbiome as a screening tool for colorectal cancer [2014] [Cancer Prevention Research] [Journal] [80000706 ]
[1.49 ] Virulence genes are a signature of the microbiome in the colorectal tumor microenvironment [2015] [Genome Medicine] [Journal] [80000748 ]
[1.50 ] Chronic obstructive pulmonary disease upper airway microbiota alpha diversity is associated with exacerbation phenotype: a case-control observational study [2019] [Respiratory Research] [Journal] [80001100 ]
[1.51 ] Dysbiosis signatures of gut microbiota in coronary artery disease [2018] [Physiological genomics] [Journal] [80000879 ]
[1.52 ] Alterations of the gut microbiota in patients with COVID-19 or H1N1 Influenza [2020] [Clinical Infectious Diseases] [Journal] [80001419 ]
[1.53 ] Altered fecal microbiota in paediatric inflammatory bowel disease [2015] [Journal of Crohn's and Colitis] [Journal] [80000564 ]
[1.54 ] Colonic microbiota is associated with inflammation and host epigenomic alterations in inflammatory bowel disease [2020] [Nature communications] [Journal] [80001325 ]
[1.55 ] Fecal dysbiosis in infants with cystic fibrosis is associated with early linear growth failure [2020] [Nature medicine] [Journal] [80001409 ]
[1.56 ] Comparison of oropharyngeal microbiota from children with asthma and cystic fibrosis [2017] [Mediators of Inflammation] [Journal] [80000734 ]
[1.57 ] Gut microbial diversity assessment of Indian Type -2-diabetics reveals alterations in eubacteria, archaea, and eukaryotes. [2017] [Frontiers in Microbiology] [Journal] [80000442 ]
[1.58 ] Altered microbiome composition in individuals with fibromyalgia [2019] [Research] [Pain] [Journal] [80001112 ]
[1.59 ] Signatures of early frailty in the gut microbiota [2016] [Genome Medicine] [Journal] [80001026 ]
[1.60 ] Association between fecal microbiota and generalized anxiety disorder: severity and early treatment response [2019] [Journal of Affective Disorders] [Journal] [80001071 ]
[1.61 ] Oral microbiome profiling in smokers with and without head and neck cancer reveals variations between health and disease [2020] [Cancer Prevention Research] [Journal] [80001326 ]
[1.62 ] Microbiome and bile acid profiles in duodenal aspirates from patients with liver cirrhosis: the microbiome, microbial markers and liver disease study [2018] [Hepatology Research] [Journal] [80000781 ]
[1.63 ] Specific gut and salivary microbiota patterns are linked with different cognitive testing strategies in minimal hepatic encephalopathy [2019] [The American Journal of Gastroenterology] [Journal] [80001092 ]
[1.64 ] Intestinal microbiota in Hirschsprung Disease [2018] [Journal of Pediatric Gastroenterology and Nutrition] [Journal] [80000783 ]
[1.65 ] An altered intestinal mucosal microbiome in HIV-1 infection is associated with mucosal and systemic immune activation and endotoxemia. [2014] [Mucosal Immunology] [Journal] [80000343 ]
[1.66 ] Dynamic of the human gut microbiome under infectious diarrhea [2022] [Study] [Current Opinion in Microbiology] [Journal] [80002290 ]
[1.67 ] Molecular characterization of the intestinal microbiota in patients with and without abdominal bloating [2016] [American journal of physiology. Gastrointestinal and liver physiology] [Journal] [80000352 ]
[1.68 ] Role of Butyrate, a Gut Microbiota Derived Metabolite, in Cardiovascular Diseases: A comprehensive narrative review [2022] [Review] [Frontiers in Pharmacology] [Journal] [80002402 ]
[1.69 ] Dysbiosis of gut microbiota and short-chain fatty acids in acute ischemic stroke and the subsequent risk for poor functional outcomes [2020] [Research] [Journal of Parenteral and Enteral Nutrition] [Journal] [80001423 ]
[1.70 ] Changes in blood microbiota profiles associated with liver fibrosis in obese patients: a pilot analysis [2016] [Hepatology] [Journal] [80000584 ]
[1.71 ] Correlation between the human fecal microbiota and depression. [2014] [Neurogastroenterology & Motility] [Journal] [80000264 ]
[1.72 ] Gut microbiota in early pediatric multiple sclerosis: a case-control study [2016] [European Journal of Neurology] [Journal] [80000269 ]
[1.73 ] Microbiota stratification identifies disease-specific alterations in neuro-Behcet's disease and multiple sclerosis [2019] [Clinical and Experimental Rheumatology] [Journal] [80001269 ]
[1.74 ] Lack of short-chain fatty acids and overgrowth of opportunistic pathogens define dysbiosis of neuromyelitis optica spectrum disorders: a Chinese pilot study [2019] [Multiple Sclerosis Journal] [Journal] [80001156 ]
[1.75 ] The association between gut microbiota composition and body mass index in Chinese male college students, as analyzed by next-generation sequencing [2019] [The Britisch Journal of Nutrition] [Journal] [80001120 ]
[1.76 ] Gut microbiota dysbiosis worsens the severity of acute pancreatitis in patients and mice. [2019] [Journal of Gastroenterology] [Journal] [80001237 ]
[1.77 ] Parkinson's Disease and Parkinson's Disease medications have distinct signatures of the gut microbiome. [2017] [Movement Disorders] [Journal] [80000277 ]
[1.78 ] Exploring the multifactorial aspects of Gut Microbiome in Parkinson’s Disease [2022] [Review] [Folia Microbiologica] [Journal] [80002403 ]
[1.79 ] Pouch inflammation is associated with a decrease in specific bacterial taxa. [2015] [Gastroenterology] [Journal] [80000325 ]
[1.80 ] The gut microbial profile in patients with primary sclerosing cholangitis is distinct from patients with ulcerative colitis without biliary disease and healthy controls [2017] [Gut] [Journal] [80000516 ]
[1.81 ] Decreased bacterial diversity characterizes an altered gut microbiota in psoriatic arthritis and resembles dysbiosis of inflammatory bowel disease. [2015] [Arthritis Rheumatol] [Journal] [80000525 ]
[1.82 ] Correlation between gut microbiota diversity and psychogenic erectile dysfunction [2021] [Study] [Translational Andrology and Urology] [Journal] [80002269 ]
[1.83 ] The gut microbiome from patients with schizophrenia modulates the glutamate-glutamine-GABA cycle and schizophrenia-relevant behaviors in mice [2019] [Science advances] [Journal] [80000888 ]
[1.84 ] The fecal microbiome in pediatric patients with short bowel syndrome. [2015] [Journal of Parenteral and Enteral Nutrition] [Journal] [80000244 ]
[1.85 ] Altered microbiota associated with abnormal humoral immune responses to commensal organisms in enthesitis-related arthritis [2014] [Arthritis Research & Therapy] [Journal] [80000461 ]
[1.86 ] The Controversial Role of Human Gut Lachnospiraceae [2020] [Review] [Microorganisms] [Journal] [80001727 ]
[1.87 ] Gut Microbiota Profile and Its Association with Clinical Variables and Dietary Intake in Overweight/Obese and Lean Subjects: A Cross-Sectional Study [2021] [Clinical study] [Nutrients] [Journal] [80001896 ]
[1.88 ] Maternal Vegetable and Fruit Consumption during Pregnancy and Its Effects on Infant Gut Microbiome [2021] [Clinical study] [Nutrients] [Journal] [80001899 ]
[1.89 ] Nuclear and Mitochondrial Genome, Epigenome and Gut Microbiome: Emerging Molecular Biomarkers for Parkinson’s Disease [2021] [Review] [International journal of molecular sciences] [Journal] [80002071 ]
[1.90 ] Fueling Gut Microbes: A Review of the Interaction between Diet, Exercise, and the Gut Microbiota in Athletes [2021] [Review] [Advances in Nutrition] [Journal] [80002173 ]
[1.91 ] Effect of Standardized Grape Powder Consumption on the Gut Microbiome of Healthy Subjects: A Pilot Study [2021] [Research] [Nutrients] [Journal] [80002184 ]
[1.92 ] Aberrant enteric neuromuscular system and dysbiosis in amyotrophic lateral sclerosis [2021] [Study] [Gut microbes] [Journal] [80002373 ]