Disease
Microbiota ☳
Metabolome
Factor
Lachnospiraceae ⇒ Clostridiales {10000240}
Record Keys
Organism: Lachnospiraceae
Parent:
Details
Initialisation date: 2020-09-22
Meta Information
Rank:
Domain:
Zone: [ ]
Enzyme: [ ]
Function: [ ]
Notes: - Short chain fatty acid producer
Shared Reference Notes
[1.90 ] Lachnospiraceae family) are the main genera that have been detected in the human intestine by metagenomics analyses. - All members of Lachnospiraceae are anaerobic, fermentative, and chemoorganotrophic, and some display strong hydrolyzing activities, through the activity of pectin methyl-esterase, pectate lyase, xylanase, α-L-arabinofuranosidase, β-xylosidase α- and β-galactosidase, α- and β-glucosidase, N-acetyl-β-glucosaminidase, or α-amylase.
- Lachnospiraceae are present in early infants, found even in the meconium.
- increases in Lachnospiraceae abundances are associated with aging.
- Lachnospiraceae abundance also increases in the intestinal lumen of subjects with different diseases, although the taxa of this family have repeatedly shown their ability to produce beneficial metabolites for the host.
[1.91 ] Lachnospiraceae were negatively associated with body fat, LDL and total cholesterol.
- Lachnospiraceae is associated with lipid cardiovascular risk factors.
[1.92 ] Lachnospiraceae
[#Maternal consumption of dietary fibre ] - Higher maternal consumption of dietary fiber > infant > Lower Lachnospiraceae count.
[1.93 ] [#Parkinson’s Disease ] Lachnospiraceae > reduction in anti-inflammatory and neuroprotective metabolite in PD
Increased Bacteroides and Verrucomicrobia > Metabolites correlated positively with the frequency of the proinflammatory cytokines TNF-α and IFN-γ
[1.89 ] #Protein powder consumption > decrease in Lachnospiraceae , #Roseburia , #Blautia , Synergistales, #Coprococcus , #Lactobacillales , Bacilli, #Bifidobacterium longum and #Firmicutes .
- #Protein powder consumption > higher abundance of #Bacteroidetes .
[1.94 ] #Grape powder consumption > significantly increased the alpha diversity index of the gut microbiome > increasing #Verrucomicrobia at the phylum level, and a significant increase in #Akkermansia and increase in #Flavonifractor and Lachnospiraceae_UCG-010 > decrease in #Bifidobacterium and #Dialister at the genus level.
[1.16 ] [#Gastric carcinoma ] #Aquabacterium , #Streptococcus and Lachnospiraceae > predict gastric cancer.
- patients with low levels of #Streptococcus and Lachnospiraceae > more likely to live with gastric cancer without it getting worse.
- Patient > more bacterial genes involved in the breakdown of #D-galacturonate > play a key role in the development of gastric cancer
[1.82 ] [#Psychogenic erectile dysfunction ] #Alloprevotella .
- Erectile dysfunction > increased #Streptococci and #Subdoligranulum
- Erectile dysfunction > decreased #Prevotella sp.9, #Blautia , Lachnospiraceae NK4A136 groups and #Roseburia .
[1.66 ] [#Infectious diarrhea ] #Blautia , #Prevotella , #Faecalibacterium , Lachnospiraceae , #Ruminococcaceae , etc.), leading to a depletion of associated metabolites such as #Short Chain Fatty Acid (SCFAs)
[1.10 ] [#Cognitive impairment ] #Barnesiella was positively associated with the first principal component, DSST, and category fluency;
- Lachnospiraceae FCS020 group was positively associated with DSST.
- #Sutterella was negatively associated with MoCA
[1.95 ] [#Amyotrophic lateral sclerosis ] #Clostridium sp. ASF502, Lachnospiraceae bacterium A4), inflammation (e.g., #Enterohabdus Muris ,), and metabolism (e.g., #Desulfovibrio fairfieldensis ) at 1- and 2-month-old SOD1G93A mice, suggesting the early microbial contribution to the pathological changes.
[1.68 ] [#Heart failure ] [#Eubacterium hallii , #Ruminococcaceae ] #Butyrate -producing bacteria, especially, Lachnospiracea and Ruminococcacea families.
- reduction of the #Butyrate -producing Eubacterium Halli and Lachnospiracea is correlated with increased inflammation, severity of disease, heart damage and mortality
[#Ischemic stroke ] - bacteria with capacity of butyrate production, Lachnospiraceae and #Ruminococcaceae , were depleted in individuals at a high risk of stroke. Fecal butyrate concentrations also were low in these people
[1.78 ] [#Parkinson’s Disease ] #Prevotellaceae (Prevotella), #Ruminococcaceae (#Faecalibacterium ), Lachnospiraceae (#Blautia , #Roseburia ) that produce SCFA and help in the synthesis of mucin to maintain the intestinal integrity are considerably lower in abundance in PD
[1.96 ] [#Inflamatory bowel disease , #Systemic anti-microbiota IgG ] #Collinsella , #Bifidobacterium , Lachnospiraceae , and #Ruminococcaceae .
[1.97 ] [#Multiple Sclerosis ] Lachnospiraceae , and #Anaerostipes produce butyrate, which acts via G-protein coupled receptors activation and histone deacetylase inhibition to suppress CNS demyelination, the main pathological feature in MS.
[1.98 ] [#Rheumatoid Arthritis ] Lachnospiraceae and #Ruminococcaceae families.
- Analysis identified a bacterial strain from the #Subdoligranulum genus that was associated with autoantibody development.
- Mice colonized with this #Subdoligranulum isolate developed arthritis with pathology similar to human RA.
Author: MetaBiomIdentifier: 10000240URL: https://www.metabiom.org/microbiota/135/lachnospiraceaeKeywords: Microbiome, Dysbiosis, Microbiota, Organism, Bacteria
Common References
[1.1 ] Characterization of gut microbiota composition and functions in patients with chronic alcohol overconsumption 80001029 ]
[1.2 ] Analysis of the gut microbiota in alopecia areata: identification of bacterial biomarkers 80001236 ]
[1.3 ] Evaluation of the microbial diversity in amyotrophic lateral sclerosis using high-throughput sequencing 80001142 ]
[1.4 ] Intestinal dysbiosis in Ankylosing Spondylitis 80000328 ]
[1.5 ] Altered gut microbiota in Chinese children with autism spectrum disorders 80000976 ]
[1.6 ] Molecular assessment of bacterial vaginosis by Lactobacillus abundance and species diversity 80000638 ]
[1.7 ] Amplicon-based microbiome study highlights the loss of diversity and the establishment of a set of species in patients with dentin caries 80001211 ]
[1.8 ] Salivary microbiota and metabolome associated with celiac disease 80000528 ]
[1.9 ] Alterations of Bacteroides sp., Neisseria sp., Actinomyces sp., and Streptococcus sp. populations in the oropharyngeal microbiome are associated with liver cirrhosis and pneumonia. 80000609 ]
[1.10 ] Association of the Gut Microbiota With Cognitive Function in Midlife 80002335 ]
[1.11 ] The gut microbiota in collagenous colitis shares characteristics with inflammatory bowel diseas-associated dysbiosis 80001117 ]
[1.12 ] Colinic mucosa-associated microbiota is influenced by an interaction of Crohn disease and FUT2 (Secretor) genotype 80001200 ]
[1.13 ] Disrupted progression of the intestinal microbiota with age in children with cystic fibrosis 80000388 ]
[1.14 ] A metagenome-wide association study of gut microbiota in type 2 diabetes. 80000240 ]
[1.15 ] Specific changes in faecal microbiota are associated with familial mediterranean fever 80001097 ]
[1.16 ] Fecal Streptococcus Alteration Is Associated with Gastric Cancer Occurrence and Liver Metastasis 80002252 ]
[1.17 ] Alterations in gut microbiota of gestational diabetes patients during the first trimester of pregnancy 80001364 ]
[1.18 ] Gut Microbiome Signatures in the Progression of Hepatitis B Virus-Induced Liver Disease 80002427 ]
[1.19 ] Deep sequencing reveals microbiota dysbiosis of tongue coat in patients with liver carcinoma 80001032 ]
[1.20 ] 16S rRNA gene sequencing reveals altered composition of gut microbiota in individuals with kidney stones 80000675 ]
[1.21 ] Specific gut microbiome signature predicts the early-stage lung cancer 80001413 ]
[1.22 ] Proinflammatory sulfur-reducing bacteria are more abundant in colonic biopsies of patients with microscopic colitis compared to healthy controls 80000870 ]
[1.23 ] Structural and functional characterization of the gut microbiota in elderly women with migraine 80001365 ]
[1.24 ] Bile acids associate with specific gut microbiota, low-level alcohol consumption and liver fibrosis in patients with non-alcoholic fatty liver disease 80001417 ]
[1.25 ] Oral microbial community composition is associated with pancreatic cancer: a case-control study in Iran 80001273 ]
[1.26 ] Gut microbiota differs between parkinson’s disease patients and healthy controls in northeast China 80001147 ]
[1.27 ] The gut-adherent microbiota of PSC-IBD is distinct to that of IBD 80000518 ]
[1.28 ] Dysbiosis of gut microbiota was closely associated with psoriasis 80001218 ]
[1.29 ] Alterations in the gut microbiota of patients with silica-induced pulmonary fibrosis 80000939 ]
[1.30 ] Dialister as a microbial marker of disease activity in Spondyloarthritis 80000453 ]
[1.31 ] Subgingival microbiota dysbiosis in systemic lupus erythematosus: association with periodontal status. 80000454 ]
[1.32 ] Defining dysbiosis in patients with urolithiasis_DUBLICATE 80000950 ]
[1.33 ] Subgingival dysbiosis in smoker and non-smoker patients with chronic periodontitis 80000444 ]
[1.34 ] Drinking alcohol is associated with variation in the human oral microbiome in a large study of american adults 80000944 ]
[1.35 ] Altered microbiomes distinguish Alzheimer’s disease from amnestic mild cognitive impairment and health in a Chinese cohort 80001073 ]
[1.36 ] Distinctive subpopulations of the intestinal microbiota are present in women with unexplained chronic anovulation 80000927 ]
[1.37 ] Helicobacter pylori infection aggravates dysbiosis of gut microbiome in children with gastritis 80001277 ]
[1.38 ] Case-Control study of the effects of gut microbiota composition on neurotransmitter metabolic pathways in children with attention deficit hyperactivity disorder 80001372 ]
[1.39 ] Alterations of oral microbiota distinguish children with autism spectrum disorders from healthy controls 80000691 ]
[1.40 ] Altered gut microbiota and short chain fatty acids in Chinese children with autism spectrum disorder 80000947 ]
[1.41 ] Oral microbiota in autoimmune polyendocrine syndrome type 1 80000749 ]
[1.42 ] Sequencing of 16S rRNA reveals a distinct salivary microbiome signature in Behcet’s disease 80000770 ]
[1.43 ] Extensive description and comparison of human supra-gingival microbiome in root caries and health. 80000363 ]
[1.44 ] Duodenal mucosa of patients with type 1 diabetes shows distinctive inflammatory profile and microbiota 80000520 ]
[1.45 ] Altered diversity and composition of gut microbiota in Chinese patients with chronic pancreatitis 80001241 ]
[1.46 ] Impact of cigarette smoking on the middle meatus microbiome in health and chronic rhinosinusitis 80000887 ]
[1.47 ] Altered profile of human gut microbiome is associated with cirrhosis and its complications 80000281 ]
[1.48 ] The human gut microbiome as a screening tool for colorectal cancer 80000706 ]
[1.49 ] Virulence genes are a signature of the microbiome in the colorectal tumor microenvironment 80000748 ]
[1.50 ] Chronic obstructive pulmonary disease upper airway microbiota alpha diversity is associated with exacerbation phenotype: a case-control observational study 80001100 ]
[1.51 ] Dysbiosis signatures of gut microbiota in coronary artery disease 80000879 ]
[1.52 ] Alterations of the gut microbiota in patients with COVID-19 or H1N1 Influenza 80001419 ]
[1.53 ] Altered fecal microbiota in paediatric inflammatory bowel disease 80000564 ]
[1.54 ] Colonic microbiota is associated with inflammation and host epigenomic alterations in inflammatory bowel disease 80001325 ]
[1.55 ] Fecal dysbiosis in infants with cystic fibrosis is associated with early linear growth failure 80001409 ]
[1.56 ] Comparison of oropharyngeal microbiota from children with asthma and cystic fibrosis 80000734 ]
[1.57 ] Gut microbial diversity assessment of Indian Type -2-diabetics reveals alterations in eubacteria, archaea, and eukaryotes. 80000442 ]
[1.58 ] Altered microbiome composition in individuals with fibromyalgia 80001112 ]
[1.59 ] Signatures of early frailty in the gut microbiota 80001026 ]
[1.60 ] Association between fecal microbiota and generalized anxiety disorder: severity and early treatment response 80001071 ]
[1.61 ] Oral microbiome profiling in smokers with and without head and neck cancer reveals variations between health and disease 80001326 ]
[1.62 ] Microbiome and bile acid profiles in duodenal aspirates from patients with liver cirrhosis: the microbiome, microbial markers and liver disease study 80000781 ]
[1.63 ] Specific gut and salivary microbiota patterns are linked with different cognitive testing strategies in minimal hepatic encephalopathy 80001092 ]
[1.64 ] Intestinal microbiota in Hirschsprung Disease 80000783 ]
[1.65 ] An altered intestinal mucosal microbiome in HIV-1 infection is associated with mucosal and systemic immune activation and endotoxemia. 80000343 ]
[1.66 ] Dynamic of the human gut microbiome under infectious diarrhea 80002290 ]
[1.67 ] Molecular characterization of the intestinal microbiota in patients with and without abdominal bloating 80000352 ]
[1.68 ] Role of Butyrate, a Gut Microbiota Derived Metabolite, in Cardiovascular Diseases: A comprehensive narrative review 80002402 ]
[1.69 ] Dysbiosis of gut microbiota and short-chain fatty acids in acute ischemic stroke and the subsequent risk for poor functional outcomes 80001423 ]
[1.70 ] Changes in blood microbiota profiles associated with liver fibrosis in obese patients: a pilot analysis 80000584 ]
[1.71 ] Correlation between the human fecal microbiota and depression. 80000264 ]
[1.72 ] Gut microbiota in early pediatric multiple sclerosis: a case-control study 80000269 ]
[1.73 ] Microbiota stratification identifies disease-specific alterations in neuro-Behcet’s disease and multiple sclerosis 80001269 ]
[1.74 ] Lack of short-chain fatty acids and overgrowth of opportunistic pathogens define dysbiosis of neuromyelitis optica spectrum disorders: a Chinese pilot study 80001156 ]
[1.75 ] The association between gut microbiota composition and body mass index in Chinese male college students, as analyzed by next-generation sequencing 80001120 ]
[1.76 ] Gut microbiota dysbiosis worsens the severity of acute pancreatitis in patients and mice. 80001237 ]
[1.77 ] Parkinson’s Disease and Parkinson’s Disease medications have distinct signatures of the gut microbiome. 80000277 ]
[1.78 ] Exploring the multifactorial aspects of Gut Microbiome in Parkinson’s Disease 80002403 ]
[1.79 ] Pouch inflammation is associated with a decrease in specific bacterial taxa. 80000325 ]
[1.80 ] The gut microbial profile in patients with primary sclerosing cholangitis is distinct from patients with ulcerative colitis without biliary disease and healthy controls 80000516 ]
[1.81 ] Decreased bacterial diversity characterizes an altered gut microbiota in psoriatic arthritis and resembles dysbiosis of inflammatory bowel disease. 80000525 ]
[1.82 ] Correlation between gut microbiota diversity and psychogenic erectile dysfunction 80002269 ]
[1.83 ] The gut microbiome from patients with schizophrenia modulates the glutamate-glutamine-GABA cycle and schizophrenia-relevant behaviors in mice 80000888 ]
[1.84 ] The fecal microbiome in pediatric patients with short bowel syndrome. 80000244 ]
[1.85 ] Altered microbiota associated with abnormal humoral immune responses to commensal organisms in enthesitis-related arthritis 80000461 ]
[1.86 ] Long-term daily high-protein, drained yoghurt consumption alters abundance of selected functional groups of the human gut microbiota and fecal short-chain fatty acid profiles in a cohort of overweight and obese women 80002459 ]
[1.87 ] Mediterranean diet intervention in overweight and obese subjects lowers plasma cholesterol and causes changes in the gut microbiome and metabolome independently of energy intake 80001473 ]
[1.88 ] Family SES Is Associated with the Gut Microbiome in Infants and Children 80002079 ]
[1.89 ] Fueling Gut Microbes: A Review of the Interaction between Diet, Exercise, and the Gut Microbiota in Athletes 80002173 ]
[1.90 ] The Controversial Role of Human Gut Lachnospiraceae 80001727 ]
[1.91 ] Gut Microbiota Profile and Its Association with Clinical Variables and Dietary Intake in Overweight/Obese and Lean Subjects: A Cross-Sectional Study 80001896 ]
[1.92 ] Maternal Vegetable and Fruit Consumption during Pregnancy and Its Effects on Infant Gut Microbiome 80001899 ]
[1.93 ] Nuclear and Mitochondrial Genome, Epigenome and Gut Microbiome: Emerging Molecular Biomarkers for Parkinson’s Disease 80002071 ]
[1.94 ] Effect of Standardized Grape Powder Consumption on the Gut Microbiome of Healthy Subjects: A Pilot Study 80002184 ]
[1.95 ] Aberrant enteric neuromuscular system and dysbiosis in amyotrophic lateral sclerosis 80002373 ]
[1.96 ] The systemic anti-microbiota IgG repertoire can identify gut bacteria that translocate across gut barrier surfaces 80002548 ]
[1.97 ] Alterations of host-gut microbiome interactions in multiple sclerosis 80002607 ]
[1.98 ] Clonal IgA and IgG autoantibodies from individuals at risk for rheumatoid arthritis identify an arthritogenic strain of
Subdoligranulum 80002636 ]
