Disease
Microbiota ☳
Metabolome
Factor
Ruminococcaceae ⇒ Faecalibacterium {10000187}
Record Keys
Parent:
Definition: Faecalibacterium
Details
Initialisation date: 2022-01-24
Meta Information
Rank:
Domain:
Zone: [ ]
Enzyme: [ ]
Function: Mucin-degrading, Anti-inflammatory, Fatigue-inducing
Notes:
- Short chain fatty acid producer
Shared Reference Notes
[1.1 ] - Reduced abundance of Faecalibacterium was found to be predictive of RA and this bacterium was found to be significantly positively correlated with a number of metabolites including the vitamin B metabolites riboflavin, nicotinate and pantothenate; nucleotides adenine, guanine and uracil; and the SCFA butyrate.
- As a butyrate producer, Faecalibacterium is generally considered beneficial
[1.2 ] [#Autism ] - Increase in Faecalibacterium in ASD children is responsible for the progression of inflammatory processes, with increased levels of type I interferon, and the alteration of the intestinal barrier.
[1.3 ] [#Alzheimer’s disease ] - Increasing the relative abundance of #Bacteroides and Faecalibacterium may improve cognitive levels
[1.4 ] [#Obesity , #Diabetes Type 2 ] [#Gender , #Resistant starch ] - gut microbiota, especially Faecalibacterium , Predict postprandial glucose response (PPGR) after eating potatoes.
[1.5 ] [#Chronic fatigue syndrome , #Inflamatory bowel disease , #Multiple Sclerosis ] - MC/CFS > a reduction of Faecalibacterium was also found in IBD patients with fatigue (compared to IBD patients without fatigue), , #Cancer -related fatigue (compared to #Cancer patients with low fatigue) and other autoimmune diseases such as MS and #Diabetes Type 1 .
[#Chronic fatigue syndrome ] - MC/CFS > microbiome alterations that were consistent with an increased inflammation of the gut, namely significantly increased #Lactonifactor and #Alistipes
- in particular an increase of #Alistipes and a decrease of butyrate-producer Faecalibacterium were considered as top biomarkers with potential diagnostic value
- abundance of #Bifidobacterium and Faecalibacterium to be reduced in the affected twin compared to the non-affected one.
- Decreases in Faecalibacterium and increases in #Coprobacillus were found.
- Gut abundances of #Coprobacillus , of #Eggerthella and #Blautia were best able to distinguish patients from controls.
- Decreases in Faecalibacterium and increases in #Coprobacillus were found.
- distinct microbial pattern with decreased anti-inflammatory #Firmicutes
[1.6 ] [#Infectious diarrhea ] - A drastic disappearance of obligate anaerobic gut commensals (#Blautia , #Prevotella , Faecalibacterium , #Lachnospiraceae , #Ruminococcaceae , etc.), leading to a depletion of associated metabolites such as #Short Chain Fatty Acid (SCFAs)
[1.7 ] [#Parkinson’s Disease ] - #Prevotellaceae (Prevotella), #Ruminococcaceae (Faecalibacterium ), #Lachnospiraceae (#Blautia , #Roseburia ) that produce SCFA and help in the synthesis of mucin to maintain the intestinal integrity are considerably lower in abundance in PD
[1.8 ] - Decreases in SCFA-producing bacteria, specifically belonging to #Akkermansia and Faecalibacterium genera, have also been detected in mice subject to 7-day paradoxical #Sleep Deprivation and 3-day continuous #Sleep Deprivation .
- Decreases in Bifidobacterium and Lactobacillus genera have been seen in mice subject to 5 days of sleep disruption.
- #Sleep Deprivation –induced dysbiosis in mice resulted in increased intestinal permeability and reduced abundance of SCFAs, features that were both reversed following subsequent administration of #Lactobacillus plantarum .
- patients with psoriasis report a relative reduction in intestinal abundance of #Akkermansia , #Ruminococcus , or Faecalibacterium genera, which are all comprised of mucin-degrading SCFA-producing commensals.
[1.9 ] -The antibacterial and antitumor defensin (HBD1) showed decreased levels in #Prostate cancer patients, while others (HBD2 and 3) were considerably increased.
- Abundance of #Staphylococcus , #Corynebacterium and #Oxyphotobacteria genera was significantly higher, the abundance of Faecalibacterium and #Bacteroides genera were significantly lower in prostate tumor samples compared to non-tumor samples.
- #Bacteroides , Parabacteroides and Faecalibacterium abundance gradually decreased with the combined increase in HBD2 and HBD3.
- Higher #Corynebacterium and #Staphylococcus abundances were measured together with higher HBD2 and HBD3 urinary levels.
[#Asthma ] [#Children ] - low α-diversity and relative abundance of particular gut-commensal bacteria genera (#Bifidobacterium , Faecalibacterium , #Ruminococcus , and #Roseburia ) are associated with childhood respiratory diseases.
[1.11 ] - the intestines and colon are enriched with anaerobes including the #Clostridium and Faecalibacterium genera.
[1.12 ] [#Clostridium difficile associated disease ] - #Vancomycin is used for C. difficile (CDI) which is associated with decrease in number of gut microbes like #Bacteroidetes , #Fuminococcus , and Faecalibacterium and increases in #Proteobacteria species.
[1.13 ] - At the genus level, #Prevotella and #Bacteroides were significantly enriched in the #Meditation group.
- Two beneficial bacterial genera (#Megamonas and Faecalibacterium ) were significantly enriched in the #Meditation group.
- Several pathways—including glycan biosynthesis, metabolism and lipopolysaccharide biosynthesis—were significantly enriched in the #Meditation group.
- Plasma levels of clinical risk factors were significantly decreased in the #Meditation group, including total #Cholesterol and apolipoprotein B.
[1.14 ] [#Bipolar disorder , #Depression ] - Depressive stages in BD patients manifested in form of melancholia are associated with higher IgA responses to #Citrobacter koseri than in healthy or non-melancholic depressed individuals.
- - in BD patients with a depressive episode > increased levels of #Coriobacteria and #Actinobacteria together with decreased #Ruminococcaceae and Faecalibacterium .
[1.15 ] - Butyrylated high-amylose maize resistant starch decreased red meat-derived pro-mutagenic adduct O6-methyl-2-deoxyguanosine and related CRC risk.
- Certain #Butyrate -producing bacteria such as #Clostridium , #Ruminococcus , Faecalibacterium spp., #Eubacterium spp., and #Roseburia , were found to decrease in relative frequency in CRC patients.
- #Butyrate inhibited the growth of CRC cells and induced their apoptosis in vitro at pharmacologically high concentrations.
[1.16 ] [#Diabetes Type 2 ] - A reduction in the #Lachnospira , #Roseburia , Faecalibacterium and #Coprococcus genera in the T2D group.
- These genera were #Butyrate producers.
- The decrease of these genera favored #Obesity and the development of diseases.
[1.17 ] [#Chronic fatigue syndrome ] [#γ-butyrobetaine ] - Decreased γ-butyrobetaine correlated with increased Faecalibacterium .
[1.18 ] [#Parkinson’s Disease ] - PD > increased relative abundance of family Enterobacteriaceae, genera #Akkermansia , #Lactobacillus , #Bifidobacterium .
- PD > decreased relative abundance of family #Lachnospiraceae , Faecalibacterium
[1.19 ] [#Bipolar disorder , #Major depressive disorder ] - MDD and BD had more commonalities, including higher #Enterococcus , #Flavonifractor , and #Streptococcus , and lower Faecalibacterium and #Ruminococcus .
[#Bipolar disorder ] - BD patients with a depressive episode > increased levels of #Coriobacteria and #Actinobacteria together with decreased #Ruminococcaceae and Faecalibacterium .
[#High-protein diet ] - Excessive protein intake > causing the growth of protein fermenting bacteria as #Clostridium , #Desulfovibrio , #Peptostreptococcus , #Acidaminococcus , #Veillonella , #Propionibacterium , Bacillus, #Bacteroides , #Staphylococcus , and other species of the #Proteobacteria family, and the loss of carbohydrate fermenting bacteria such as #Bacteroides , #Lactobacillus , #Bifidobacterium , #Prevotella , #Ruminococcus , #Roseburia , and Faecalibacterium .
[1.21 ] - Higher caffeine and #Coffee intake was related to higher alpha diversity higher relative abundance of Faecalibacterium and #Alistipes , and lower relative abundance of #Erysipelatoclostridium .
- After adjustment of vitamin B2 in multivariate analysis, the significant inverse association between #Erysipelatoclostridium count and caffeine intake remained statistically significant.
[1.22 ] [#Aging ] - the loss of #Lactobacillus and Faecalibacterium , as well as the abundance of #Oscillibacter and #Alistipes genera along with the #Eubacteriaceae family is linked to #Frailty in elderly people.
[1.23 ] [#Soybean ] - high intake of milk and soy beverages was associated with a higher abundance of beneficial faecal microbes including Faecalibacterium , #Bifidobacterium , and #Parabacteroides .
- consumption of fermented soy milk was associated with increased abundance of #Bifidobacterium , bifidobacteria and/or Lactobacillus compared to unfermented soy milk.
[1.24 ] [#Faecalibacterium prausnitzii ] [#Physical activity ] - in males with normal BMI, a stronger grip strength was associated with a higher relative abundance of Faecalibacterium and F. prausnitzii compared with lower grip strength.
[1.25 ] [#CVD , #Obesity ] [#Inulin-Type Fructans ] - Addition of ITF to the #Plant-based diet reduced microbial diversity and selectively increased #Bifidobacterium and Faecalibacterium . -- The change in the latter was significantly associated with higher values of insulin and HOMA-IR and lower HDL #Cholesterol .
- The LDL:HDL ratio and the concentrations of IL-10, MCP-1 and TNFα were significantly elevated in the ITF-subgroup.
[1.26 ] [#Whole grains ] - Several #Butyrate -producers (e.g., Faecalibacterium , #Roseburia , Butyriciococcus) were inversely associated with colonic transit time and/or faecal pH, while the mucin-degraders #Akkermansia and #Ruminococcaceae showed the opposite association.
[1.27 ] [#Athletes ] - Faecalibacterium , #Sutterella , #Clostridium , #Haemophilus , and #Eisenbergiella were the most abundant in bodybuilders, while #Bifidobacterium and #Parasutterella were the least abundant.
[#Short Chain Fatty Acid ] [#Exercise training ] - A six-week moderate to intense aerobic exercise (30–60 min) program can induce a shift in the SCFA-producing Faecalibacterium and #Lachnospira spp. and genetic machinery (BCoATe) substantially in lean versus obese participants.
[1.28 ] [#Acute lymphoblastic leukemia ] - #Roseburia , #Dialister , #Prevotella , Faecalibacterium and #Anaerostipes showed reduced relative abundance in #Children with ALL at the time of diagnosis
- delayed maturation of the gut microbiome (characterized by reduced relative abundance of the genera #Roseburia , #Dialister , #Prevotella , Faecalibacterium and #Blautia and increased abundance of #Enterococcus ), as well as reduced stool levels of #Butyrate by the age of 12 months, is associated with aberrant immune responses and an increased risk of #Asthma diagnosis by the age of 5 years
[#Aging ] - #Infants with older #Siblings exhibit increased gut microbiome α-diversity, faster gut microbiome maturation and earlier colonization with Faecalibacterium species, which are known to increase the Treg/TH17 cell ratio via inhibition of HDACs and to ameliorate gut inflammation.
[#Aging ] - A lack of older #Siblings is associated with reduced gut microbiome α-diversity and reduced relative abundance of Faecalibacterium as well as delayed maturation of the gut microbiome by the age of 12 months.
[1.29 ] [#Bacteroides-Prevotella group ] - only Faecalibacterium , but not #Blautia , #Anaerostipes , or #Megamonas , was significantly lower in the #Hypertension group
[#Lipopolysaccharide , #Short Chain Fatty Acid ] - #Hypertension groups > low gut microbial diversity and some distinctive taxa, depleted SCFA-producing bacteria, such as Ruminococcacea and Faecalibacterium , and enriched LPS-producing gram-negative bacteria, such as #Bacteroidales , #Negativiticus , and #Megamonas ,
- Faecalibacterium is the most potent #Butyrate -producing bacteria and the biomarker most closely associated with #Hypertension prevention.
[#Irritable bowel syndrome ] - IBS patients have increased levels of the bacterial families #Enterobacteriaceae , #Lactobacillaceae , and #Bacteroidales , whereas #Bifidobacterium , Faecalibacterium , and #Clostridiales were decreased compared with healthy controls.
[#Irritable bowel syndrome ] - IBS was typified by enhanced quantities of #Firmicutes and specifically in #Ruminococcus , #Clostridium , and #Dorea , along with a distinct decrease of beneficial microbes, such as #Bifidobacterium and Faecalibacterium spp
[1.31 ] - #Blautia , Faecalibacterium , and #Dorea levels were consistently more abundant in 8-year-olds with #Allergy than in #Children without #Allergy .
- Faecalibacterium abundance was correlated with IL-10 and FOXP3 mRNA levels.
- #Bacteroides and Faecalibacterium had relatively high prevalences and were more abundant in #Children with severe #Asthma .
[#Infantile eczema ] [#Faecalibacterium prausnitzii ] - Faecalibacterium is significantly increased in the microbiota of patients with #Atopic Dermatitis and eczema, and this genus represents only a single known species, F prausnitzii.
- A similar correlation with high absolute tissue eosinophil counts and percentages of tissue eosinophils is also seen in the abundance of the genera #Parabacteroides , #Bifidobacterium , #Bacteroides , #Microbacterium , Faecalibacterium , #Lactococcus , #Desulfovibrio , and #Ruminococcus .
[#Eosinophilic chronic rhinosinusitis ] - nasal dysbiosis in eCRSwNP was defined by increased relative abundances of #Sphingomonas , #Moraxellaceae , #Bacteroides , #Bifidobacterium , #Ruminococcus , and Faecalibacterium , as well as by decreased abundances of #Ralstonia , #Propionibacterium , and Propionibacter.
[1.32 ] [#Obesity ] [#Faecalibacterium prausnitzii ] - Abundance of Faecalibacterium genus members (i.e., F. prausnitzii) is greater in both women and men with higher skeletal muscle mass.
- increases in both lean mass and Faecalibacterium relative abundance are observed in normal weight subjects after #Exercise training .
[1.33 ] [#Parkinson’s Disease ] - consistent reduction in preQ0 biosynthesis at prodromal PD and early α-synucleinopathy.
- PreQ0 is a key intermediate of the biosynthesis of 7-#Deazapurine nucleoside.
- the abundance of preQ0 biosynthesis seems strongly co-occurring with genus Faecalibacterium , a butyrate-producing bacteria and an indicator of PD progression
[1.34 ] [#Bipolar disorder ] - negative association between Faecalibacterium abundance and #Depression severity in depressive and BD patients
[#Bipolar disorder ] - low abundance of Faecalibacterium , #Pseudomonas and #Fusobacterium in depressed BD patients may have implications for the neurobiology of BD
- abundance of Faecalibacterium , #Pseudomonas and #Fusobacterium was negatively correlated with the severity of #Depression .
- Faecalibacterium was found to produce a protein which was involved in anti-inflammatory activities
- abundance of #Enterobacteriaceae and #Alistipes was increased, and Faecalibacterium abundance was decreased in patients with #Major depressive disorder
[1.35 ] - Faecalibacterium causally increased the possibility of #Female infertility .
[1.36 ] [#Postmenopausal ] - Gut #Bacteria that possess β-glucuronidase and/or β-galactosidase activity can metabolize #Estrogen including #Bifidobacterium , Faecalibacterium , #Lactobacillus , #Veillonella
[1.37 ] [#Sjögren syndrome ] - Sjogren’s syndrome > an increase in #Bacteroidetes , an opportunistic commensal, and a decrease in #Firmicutes and Faecalibacterium > decreased Treg cells
- the degree of dysbiosis was partly correlated with the severity of ocular surface disease.
[1.38 ] [#Systemic lupus erythematosus ] - SLE patients displayed higher serum levels of #IL-2 and #IL-6 .
- The abundance of #Roseburia and Faecalibacterium was inversely correlated with #IL-6 , the abundance of #Roseburia had a negative correlation with #IL-2 , and the abundance of #Bacteroides had a positive correlation with #IL-2 .
[1.39 ] [#Ankylosing spondylitis , #Spondyloarthritis ] - Patients with SpA showed an enrichment of #Collinsella , and several Lachnospiraceae ASVs
- HLA-B27+ individuals displayed enriched Faecalibacterium .
- 60 bacterial genera from human gut microbiota (#Bacteroides , #Bifidobacterium , #Escherichia , Faecalibacterium , and #Lactobacillus ,) > encode β-glucuronidase and/or β-galactosidase > impacting endogenous #Estrogen metabolism
[1.41 ] [#Parkinson’s Disease ] [#Short Chain Fatty Acid ] - Decreases of short-chain fatty acid-producing genera, #Fusicatenibacter , Faecalibacterium , and #Blautia , as well as an increase of mucin-degrading genus #Akkermansia , predicted accelerated disease progression.
[1.42 ] [#Short Chain Fatty Acid ] - increased abundance of gut ##Ruminococcus and ##Alistipes in castration-resistant #Prostate cancer (CRPC) patients along with ##Bacteroidales , ##Rikenellaceae , #Faecalibacterium ,the so called SCFAs-producing microbiotas.
[1.43 ] [#Clostridiales XIV , #Clostridium cluster IV ] - #Walnut consumption at 42 g/day, increased #Butyrate -producing #Clostridium clusters XIV and IV including, Faecalibacterium , #Roseburia , while lowering the relative abundance of #Ruminococcus , #Dorea , Oscilllo, #Bifidobacteria .
[1.44 ] - patients with #Celiac Disease showed the abundance of #Streptococcus , #Lactobacillus , #Veillonella , and #Allisonella species, while the abundance of #Ruminococcus , Faecalibacterium , #Blautia , #Gemmiger , and #Anaerostipes was decreased.
[1.45 ] [#Ulcerative Colitis ] - contrary to earlier reports, no significant loss of Faecalibacterium genera was observed in UC patients, there was even a slight increase in the abundance of Faecalibacterium in UC patients.
[1.46 ] [#Gastric bypass surgery ] - Roux-en-Y gastric bypass (RYGB) resulted in clear alteration in composition of gut fungal and bacterial microbiota.
- Before surgery, patients had higher levels of #Firmicutes and #Actinobacteria and lower levels of #Verrucomicrobia
- Faecalibacterium and #Bifidobacterium showed a decrease after surgery and aerotolerant #Streptococcus was increased postoperatively.
- The relative abundance of #Proteobacteria was increased after surgery.
- Changes in fungal microbiota composition included decreases in #Candida and #Saccharomyces and increases in #Pichia .
- levels of #Verrucomicrobia and #Proteobacteria increased after the surgery procedure
- Bifidobacteriaceae abundance decreased, whereas Streptococcaceae and Enterobacteriaceae increased after surgery.
- RYGB led to increased #Firmicutes and #Actinobacteria phyla but decreased #Bacteroidetes phylum
[#Inflamatory bowel disease ] [#Escherichia coli ] - #Colectomy > there was a significant increase in the expansion of E.coli in individuals who underwent surgery and, in particular, samples from IBD patients who underwent #Colectomy had the highest abundance of E.coli.
- At 6 months, endoscopic recurrence was associated with elevated #Proteus genera and at 18 months with reduced Faecalibacterium , #Desulfovibrio and #Bilophila abundance. At 18 months severe endoscopic recurrence was associated with increase in #Proteobacteria .
[1.47 ] [#Parkinson’s Disease ] [#Roseomonas mucosa ] [#Short Chain Fatty Acid ] - #Constipation severity is significantly correlated with the decrease of #Blautia and Faecalibacterium , short chain fatty acids (SCFAs)-producing taxa that can exert positive effects on the intestinal mucosa and which are decreased in PD.
[#Parkinson’s Disease ] - #Prevotellaceae , #Lachnospiraceae , and Faecalibacterium were decreased significantly in patients with PD compared to healthy controls, while #Ruminococcaceae , #Bifidobacteriaceae , #Christensenellaceae , and #Verrucomicrobiaceae were enriched in patients with PD
[1.48 ] [#Multiple Sclerosis ] - Individuals with relapsing-remitting MS have an abundance of #Mycoplasma , #Pseudomonas , Faecalibacterium , #Haemophilus , #Anaerostipes , #Blautia , and #Dorea , while #Bacteroides , #Prevotella , #Parabacteroides , and #Adlercreutzia are relatively less common.
[1.49 ] [#Parkinson’s Disease ] - #Lactobacillus and #Bifidobacterium genus were most abundant in PD patients. #Prevotella VZCB and other Faecalibacterium were most abundant in controls.
Intervention in Disease [ ]
Author: MetaBiom
Identifier: 10000187
URL: https://www.metabiom.org/microbiota/86/faecalibacterium
Keywords: Microbiome, Dysbiosis, Microbiota, Organism, Bacteria
Common References
[1.1 ] Predictive Metagenomic Analysis of Autoimmune Disease Identifies Robust Autoimmunity and Disease Specific Microbial Signatures [2021] [Review] [Frontiers in Microbiology] [Journal] [80001705 ]
[1.2 ] The Contribution of Gut Microbiota–Brain Axis in the Development of Brain Disorders [2021] [Review] [Frontiers in Neuroscience] [Journal] [80001732 ]
[1.3 ] Composition of intestinal flora affects the risk relationship between Alzheimer’s disease/Parkinson’s disease and cancer [2022] [Review] [Biomedicine & Pharmacotherapy] [Journal] [80002199 ]
[1.4 ] Precision Nutrition Model Predicts Glucose Control of Overweight Females Following the Consumption of Potatoes High in Resistant Starch [2022] [Research] [Nutrients] [Journal] [80002227 ]
[1.5 ] The Gut Microbiome in Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS) [2022] [Review] [Frontiers in Immunology] [Journal] [80002273 ]
[1.6 ] Dynamic of the human gut microbiome under infectious diarrhea [2022] [Study] [Current Opinion in Microbiology] [Journal] [80002290 ]
[1.7 ] Exploring the multifactorial aspects of Gut Microbiome in Parkinson’s Disease [2022] [Review] [Folia Microbiologica] [Journal] [80002403 ]
[1.8 ] Sleep and the Gut Microbiome in Psoriasis: Clinical Implications for Disease Progression and the Development of Cardiometabolic Comorbidities [2020] [Review] [Journal of Psoriasis and Psoriatic Arthritis] [Journal] [80002413 ]
[1.9 ] Bladder Tissue Microbiome Composition in Patients of Bladder Cancer or Benign Prostatic Hyperplasia and Related Human Beta Defensin Levels [2022] [Study] [biomedicines] [Journal] [80002488 ]
[1.10 ] The association between early-life gut microbiota and childhood respiratory diseases: a systematic review [2022] [Review] [The Lancet Microbe] [Journal] [80002550 ]
[1.11 ] The double-edged sword of probiotic supplementation on gut microbiota structure in <i>Helicobacter pylori</i> management [2022] [Gut microbes] [Journal] [80002569 ]
[1.12 ] Correlation between human gut microbiome and diseases [2022] [Review] [Infectious Medicine] [Journal] [80002594 ]
[1.13 ] Alteration of faecal microbiota balance related to long-term deep meditation [2023] [Study] [General Psychiatry] [Journal] [80002709 ]
[1.14 ]  [2023] [Review] [Molecular Psychiatry] [Journal] [80002728 ]
[1.15 ] Microbial Metabolite Dysbiosis and Colorectal Cancer [2023] [Review] [Gut and Liver] [Journal] [80002741 ]
[1.16 ] Variation of butyrate production in the gut microbiome in type 2 diabetes patients [2023] [Clinical study] [International Microbiology] [Journal] [80002763 ]
[1.17 ] Insights into myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive metabolomics [2018] [Study] [Scientific Reports] [Journal] [80002766 ]
[1.18 ] An open label, non-randomized study assessing a prebiotic fiber intervention in a small cohort of Parkinson’s disease participants [2023] [Cohort study] [Nature communications] [Journal] [80002769 ]
[1.19 ] Microbiota–gut–brain axis mechanisms in the complex network of bipolar disorders: potential clinical implications and translational opportunities [2023] [Review] [Molecular Psychiatry] [Journal] [80002837 ]
[1.20 ] Gut-Muscle Axis Exists and May Affect Skeletal Muscle Adaptation to Training [2020] [Review] [Nutrients] [Journal] [80002842 ]
[1.21 ] The Association between Caffeine Intake and the Colonic Mucosa-Associated Gut Microbiota in Humans—A Preliminary Investigation [2023] [Study] [Nutrients] [Journal] [80002846 ]
[1.22 ] How Microbiomes Affect Skin Aging: The Updated Evidence and Current Perspectives [2022] [Review] [Life] [Journal] [80002854 ]
[1.23 ] Soy and Gastrointestinal Health: A Review [2023] [Review] [Nutrients] [Journal] [80002876 ]
[1.24 ] Physical activity‐induced alterations of the gut microbiota are BMI dependent [2023] [Study] [The FASEB Journal] [Journal] [80002881 ]
[1.25 ] Supplementation with inulin-type fructans affects gut microbiota and attenuates some of the cardiometabolic benefits of a plant-based diet in individuals with overweight or obesity [2023] [Study] [Frontiers in nutrition] [Journal] [80002882 ]
[1.26 ] Effects of a wholegrain-rich diet on markers of colonic fermentation and bowel function and their associations with the gut microbiome: a randomised controlled cross-over trial [2023] [Study] [Frontiers in nutrition] [Journal] [80003001 ]
[1.27 ] Intertwined Relationship of Mitochondrial Metabolism, Gut Microbiome and Exercise Potential [2022] [Study] [International journal of molecular sciences] [Journal] [80003004 ]
[1.28 ] Gut microbiome immaturity and childhood acute lymphoblastic leukaemia [2023] [Review] [80003007 ]
[1.29 ] The association between gut microbiome and hypertension varies according to enterotypes: a Korean study [2023] [Cohort study] [Frontiers in Microbiomes] [Journal] [80003028 ]
[1.30 ] Gut Microbiome–Brain Alliance: A Landscape View into Mental and Gastrointestinal Health and Disorders [2023] [Review] [ACS Chemical Neuroscience] [Journal] [80003039 ]
[1.31 ] Alterations of nasal microbiome in eosinophilic chronic rhinosinusitis [2023] [Journal of Allergy and Clinical Immunology] [Journal] [80003049 ]
[1.32 ] Assessing the Performance of a Novel Stool-Based Microbiome Test That Predicts Response to First Line Immune Checkpoint Inhibitors in Multiple Cancer Types [2023] [Cohort study] [Cancers] [Journal] [80003055 ]
[1.33 ] Gut microbiome dysbiosis across early Parkinson’s disease, REM sleep behavior disorder and their first-degree relatives [2023] [Nature communications] [Journal] [80003093 ]
[1.34 ] Gut microbiota and its relation to inflammation in patients with bipolar depression: a cross-sectional study [2023] [Annals of General Psychiatry] [Journal] [80003100 ]
[1.35 ] A two-sample mendelian randomization analysis investigates associations between gut microbiota and infertility [2023] [Scientific Reports] [Journal] [80003103 ]
[1.36 ] Targeting gut microbiota in osteoporosis: impact of the microbial based functional food ingredients [2024] [Review] [Food Science and Human Wellness] [Journal] [80003111 ]
[1.37 ] The Link Between Gastrointestinal Microbiome and Ocular Disorders [2023] [80003145 ]
[1.38 ] Gut microbiota: a newly identified environmental factor in systemic lupus erythematosus [2023] [Review] [Frontiers in Immunology] [Journal] [80003157 ]
[1.39 ] Spondyloarthritis, acute anterior uveitis, and Crohn’s disease have both shared and distinct gut microbiota [2023] [Arthritis & Rheumatology] [Journal] [80003209 ]
[1.40 ] Perturbations in gut microbiota composition in patients with polycystic ovary syndrome: a systematic review and meta-analysis [2023] [80003217 ]
[1.41 ] Short chain fatty acids-producing and mucin-degrading intestinal bacteria predict the progression of early Parkinson’s disease [2022] [npj parkinson's disease ] [Journal] [80003245 ]
[1.42 ] Gut microbiota-derived short-chain fatty acids promote prostate cancer progression via inducing cancer cell autophagy and M2 macrophage polarization [2023] [Neoplasia] [Journal] [80003265 ]
[1.43 ] Gut microbiome changes induced by a diet rich in fruits and vegetables [2020] [Review] [International Journal of Food Sciences and Nutrition] [Journal] [80003292 ]
[1.44 ] Microbiome Metabolites in Health and Disease [80003332 ]
[1.45 ] Enrichment of Lactic Acid-Producing Bacteria in the Fecal Microbiota of Patients with Ulcerative Colitis in North India [2023] [Advanced Gut & Microbiome Research] [Journal] [80003339 ]
[1.46 ] Erratum: Alterations of gut microbiome following gastrointestinal surgical procedures and their potential complications [2023] [Frontiers in Cellular and Infection Microbiology] [Journal] [80003367 ]
[1.47 ] Gut Microbiota: A Novel Therapeutic Target for Parkinson’s Disease [2022] [Frontiers in Immunology] [Journal] [80003405 ]
[1.48 ] Neuropsychiatric and Neurological Diseases in Relation to the Microbiota-Gut-Brain Axis: From Research to Clinical Care [2023] [Review] [80003409 ]
[1.49 ] Dietary quality and the gut microbiome in early-stage Parkinson’s disease patients [2023] [Nutritional Neuroscience] [Journal] [80003439 ]
[1.50 ] Skin microbiome differences relate to the grade of acne vulgaris [2019] [Journal of Dermatology] [Journal] [80001179 ]
[1.51 ] Allergic patients with long-term asthma display low levels of Bifidobacterium adolescentis [2016] [PLOS ONE] [Journal] [80000725 ]
[1.52 ] Temporal and long-term gut microbiota variation in allergic disease: a prospective study from infancy to school age [2019] [Allergy] [Journal] [80001034 ]
[1.53 ] Quantitative metagenomics reveals unique gut microbiome biomarkers in ankylosing spondylitis. [2017] [Genome Biology] [Journal] [80000612 ]
[1.54 ] Lower airway microbiota and mycobiota in children with sever asthma [2018] [Journal of Allergy and Clinical Immunology] [Journal] [80001065 ]
[1.55 ] Gut microbiota profile in children affected by atopic dermatitis and evaluation of intestinal persistence of a probiotic mixture [2019] [Scientific Reports] [Journal] [80000949 ]
[1.56 ] The gut microbiome composition associates with bipolar disorder and illness severity [2017] [Journal of Psychiatric Research] [Journal] [80000266 ]
[1.57 ] Molecular characterization of mucosal adherent bacteria and associations with colorectal adenomas [2010] [Gut microbes] [Journal] [80000590 ]
[1.58 ] Alteration in gut microbiota associated with hepatitis B and non-hepatitis virus related hepatocellular carcinoma [2019] [Gut Pathogens] [Journal] [80000945 ]
[1.59 ] Altered gut microbiota composition associated with eczema in infants [2016] [PLOS ONE] [Journal] [80000741 ]
[1.60 ] Characterization of the gut microbiota of Kawasaki disease patients by metagenomic analysis [2015] [Frontiers in Microbiology] [Journal] [80000556 ]
[1.61 ] An altered composition of the microbiome in microscopic colitis is driven towards the composition in healthy controls by treatment with budesonide [2019] [Scandinavian Journal of Gastroenterology] [Journal] [80001213 ]
[1.62 ] Alteration of the gut microbiota associated with childhood obesity by 16S rRNA gene sequencing [2020] [PeerJ] [Journal] [80001400 ]
[1.63 ] Identification and characterization of blood and neutrophil-associated microbiomes in patients with severe acute pancreatitis using next-generation sequencing [2018] [Frontiers in Cellular and Infection Microbiology] [Journal] [80000703 ]
[1.64 ] Meta-analysis of the Parkinson’s disease gut microbiome suggests alterations linked to intestinal inflammation [2021] [Review] [npj parkinson's disease ] [Journal] [80001726 ]
[1.65 ] Gut microbial composition in patients with psoriasis [2018] [Scientific Reports] [Journal] [80000690 ]
[1.66 ] An expansion of rare lineage intestinal microbes characterizes rheumatoid arthritis [2016] [Genome Medicine] [Journal] [80000496 ]
[1.67 ] Comparison of the ocular microbiome between chronic Stevens-Johnson syndrome patients and healthy subjects [2020] [Scientific Reports] [Journal] [80001339 ]
[1.68 ] Alterations of urinary microbiota in type 2 Diabetes Mellitus with hypertension and/or hyperlipidemia [2017] [Frontiers in Physiology] [Journal] [80000661 ]
[1.69 ] Analysis of endoscopic brush samples identified mucosa-associated dysbiosis in inflammatory bowel disease [2018] [Journal of Gastroenterology] [Journal] [80000679 ]
[1.70 ] Association study of gut flora in Wilson’s disease through high-throughput sequencing [2018] [Medicine] [Journal] [80000863 ]
[1.71 ] Alterations in the gut microbiota of patients with acquired immune deficiency syndrome [2018] [Journal of Cellular and Molecular Medicine] [Journal] [80000714 ]
[1.72 ] Persistent gut microbial dysbiosis in children with acute lymphoblastic leukemia (ALL) during chemotherapy [2020] [Microbial Ecology] [Journal] [80001424 ]
[1.73 ] Subgingival dysbiosis in smoker and non-smoker patients with chronic periodontitis [2017] [Molecular Medicine Reports] [Journal] [80000444 ]
[1.74 ] Characterization of gut microbiota composition and functions in patients with chronic alcohol overconsumption [2019] [Gut microbes] [Journal] [80001029 ]
[1.75 ] Intestinal microbiota composition in patients with amyotrophic lateral sclerosis: establishment of bacterial and archaeal communities analyses [2019] [Chinese Medical Journal] [Journal] [80001111 ]
[1.76 ] Early infancy microbial and metabolic alterations affect risk of childhood asthma [2015] [Science translational medicine] [Journal] [80000526 ]
[1.77 ] Helicobacter pylori infection aggravates dysbiosis of gut microbiome in children with gastritis [2019] [Frontiers in Cellular and Infection Microbiology] [Journal] [80001277 ]
[1.78 ] Gut microbiota profiles in treatment-naïve children with attention deficit hyperactivity disorder [2018] [Behavioural Brain Research] [Journal] [80000769 ]
[1.79 ] Gut microbial profile in biliary atresia: a case-control study [2019] [Journal of Gastroenterology and Hepatology] [Journal] [80001225 ]
[1.80 ] Gut microbiota changes in patients with bipolar depression [2019] [Advanced Science] [Journal] [80001106 ]
[1.81 ] Alterations of gut microbiota in cholestatic infants and their correlation with hepatic function [2018] [Frontiers in Microbiology] [Journal] [80000981 ]
[1.82 ] Characterization of intestinal microbiota in alcoholic patients with and without alcoholic hepatitis or chronic alcoholic pancreatitis [2018] [Scientific Reports] [Journal] [80000689 ]
[1.83 ] Alteration of the gut microbiota in Chinese population with chronic kidney disease [2017] [Scientific Reports] [Journal] [80000616 ]
[1.84 ] Altered diversity and composition of gut microbiota in Chinese patients with chronic pancreatitis [2019] [Pancreatology] [Journal] [80001241 ]
[1.85 ] Gut microbiome and serum metabolome analyses identify unsaturated fatty acids and butanoate metabolism induced by gut microbiota in patients with chronic spontaneous urticaria [2020] [Frontiers in Cellular and Infection Microbiology] [Journal] [80001363 ]
[1.86 ] Decreased fecal bacterial diversity and altered microbiome in children colonized with Clostridium difficile [2019] [Journal of Pediatric Gastroenterology and Nutrition] [Journal] [80000958 ]
[1.87 ] Human intestinal lumen and mucosa-associated microbiota in patients with colorectal cancer [2012] [PLOS ONE] [Journal] [80000305 ]
[1.88 ] Comparison of gut microbiome in human colorectal cancer in paired tumor and adjacent normal tissues [2020] [OncoTargets and Therapy] [Journal] [80001290 ]
[1.89 ] Dysbiosis signatures of gut microbiota in coronary artery disease [2018] [Physiological genomics] [Journal] [80000879 ]
[1.90 ] Alterations of the gut microbiota in patients with COVID-19 or H1N1 Influenza [2020] [Clinical Infectious Diseases] [Journal] [80001419 ]
[1.91 ] Reduced abundance of butyrate-producing bacteria species in the fecal microbial community in Crohn’s Disease. [2016] [Digestion] [Journal] [80000250 ]
[1.92 ] Fungal dysbiosis in mucosa-associated microbiota of Crohn’s disease patients [2016] [Journal of Crohn's and Colitis] [Journal] [80000760 ]
[1.93 ] Disrupted progression of the intestinal microbiota with age in children with cystic fibrosis [2016] [Scientific Reports] [Journal] [80000388 ]
[1.94 ] Gut microbiota differs in composition and functionality between children with type 1 diabetes and MODY2 and healthy control subjects: a case-control study [2018] [Diabetes Care] [Journal] [80000812 ]
[1.95 ] Implication of the gut microbiome composition of type 2 diabetic patients from northern China [2020] [Scientific Reports] [Journal] [80001348 ]
[1.96 ] Dysbiosis of urinary microbiota is positively correlated with type 2 diabetes mellitus [2017] [Oncotarget] [Journal] [80000429 ]
[1.97 ] Gut microbial dysbiosis in individuals with Sjögren’s syndrome [2020] [Microbial Cell Factories] [Journal] [80001407 ]
[1.98 ] Intestinal microbiota is altered in patients with gastric cancer from Shanxi Province, China [2019] [Digestive Diseases and Sciences] [Journal] [80001028 ]
[1.99 ] Altered gut microbiota profile in patients with generalized anxiety disorder [2018] [Journal of Psychiatric Research] [Journal] [80001066 ]
[1.100 ] Alterations of gut microbiota and blood lipidome in gestational diabetes mellitus with hyperlipidemia [2019] [Frontiers in Physiology] [Journal] [80001152 ]
[1.101 ] Hepatic glycogen storage diseases are associated to microbial dysbiosis [2019] [PLOS ONE] [Journal] [80001020 ]
[1.102 ] Molecular alteration analysis of human gut microbial composition in Graves’ disease patients [2018] [International Journal of Biological Sciences] [Journal] [80000858 ]
[1.103 ] Alterations of the gut microbiota in Hashimoto’s Thyroiditis patients [2018] [Thyroid] [Journal] [80000751 ]
[1.104 ] Microbiome and bile acid profiles in duodenal aspirates from patients with liver cirrhosis: the microbiome, microbial markers and liver disease study [2018] [Hepatology Research] [Journal] [80000781 ]
[1.105 ] Gut Microbiome Signatures in the Progression of Hepatitis B Virus-Induced Liver Disease [2022] [Study] [Frontiers in Microbiology] [Journal] [80002427 ]
[1.106 ] Effects of HIV viremia on the gastrointestinal microbiome of young MSM [2019] [AIDS] [Journal] [80000959 ]
[1.107 ] A compositional look at the human gastrointestinal microbiome and immune activation parameters in HIV infected subjects. [2014] [PLOS ONE] [Journal] [80000332 ]
[1.108 ] Gut microbiota dysbiosis contributes to the development of hypertension [2017] [Review] [Microbiome] [Journal] [80000033 ]
[1.109 ] The gut microbiome in epilepsy [2020] [Microbial Pathogenesis] [Journal] [80001252 ]
[1.110 ] The microbiome of translocated bacterial populations in patients with and without inflammatory bowel disease [2018] [Internal Medicine Journal] [Journal] [80000893 ]
[1.111 ] Alterations of microbiota in urine from women with interstitial cystitis [2012] [BMC Microbiology] [Journal] [80000409 ]
[1.112 ] Fecal and Mucosa-associated intestinal microbiota in patients with diarrhea-predominant irritable bowel syndrome [2018] [Digestive Diseases and Sciences] [Journal] [80000864 ]
[1.113 ] Mucosal microbiome profiles polygenic irritable bowel syndrome in Mestizo individuals [2020] [Frontiers in Cellular and Infection Microbiology] [Journal] [80001366 ]
[1.114 ] Alterations in gut bacterial and fungal microbiomes are associated with bacterial keratitis, an inflammatory disease of the human eye [2018] [Journal of Biosciences] [Journal] [80000905 ]
[1.115 ] Profiling the urinary microbiome in men with calcium-based kidney stones [2020] [BMC Microbiology] [Journal] [80001327 ]
[1.116 ] Altered fecal microbiota composition in patients with major depressive disorder. [2015] [Brain, Behavior, and Immunity] [Journal] [80000265 ]
[1.117 ] Gut microbiota in MS: possible influence of immunomodulators [2015] [Journal of Investigative Medicine] [Journal] [80000267 ]
[1.118 ] Dysbiosis of gut microbiota in patients with neuromyelitis optica spectrum disorders: a cross sectional study [2020] [Journal of Neuroimmunology] [Journal] [80001254 ]
[1.119 ] Nonalcoholic fatty liver disease is associated with dysbiosis independent of body mass index and insulin resistance [2018] [Scientific Reports] [Journal] [80000685 ]
[1.120 ] Dysbiosis signatures of gut microbiota along the sequence from healthy, young patients to those with overweight and obesity. [2018] [Obesity] [Journal] [80000708 ]
[1.121 ] Fecal microbiome signatures of pancreatic cancer patients [2019] [Scientific Reports] [Journal] [80001263 ]
[1.122 ] Gut microbiota dysbiosis worsens the severity of acute pancreatitis in patients and mice. [2019] [Journal of Gastroenterology] [Journal] [80001237 ]
[1.123 ] Parkinson’s Disease and Parkinson’s Disease medications have distinct signatures of the gut microbiome. [2017] [Movement Disorders] [Journal] [80000277 ]
[1.124 ] Inflammatory microbes and genes as potential biomarkers of Parkinson’s disease [2022] [Review] [npj Biofilms and Microbiomes] [Journal] [80002678 ]
[1.125 ] Metagenomics of Parkinson’s disease implicates the gut microbiome in multiple disease mechanisms [2022] [Cohort study] [Nature communications] [Journal] [80002696 ]
[1.126 ] Colonic bacterial composition in Parkinson’s Disease [2015] [Movement Disorders] [Journal] [80000275 ]
[1.127 ] Structural and functional profiles of the gut microbial community in polycystic ovary syndrome with insulin resistance (IR-PCOS): a pilot study [2019] [Research in Microbiology] [Journal] [80000919 ]
[1.128 ] Compositional and functional features of the female premenopausal and postmenopausal gut microbiota [2019] [FEBS Letters] [Journal] [80001233 ]
[1.129 ] Pouch inflammation is associated with a decrease in specific bacterial taxa. [2015] [Gastroenterology] [Journal] [80000325 ]
[1.130 ] Distinct microbiome in pouchitis compared to healthy pouches in ulcerative colitis and familial adenomatous polyposis. [2011] [Inflammatory Bowel Diseases] [Journal] [80000242 ]
[1.131 ] Early-onset preeclampsia is associated with gut microbial alterations in antepartum and postpartum women [2019] [Frontiers in Cellular and Infection Microbiology] [Journal] [80001138 ]
[1.132 ] Gut microbial profile is altered in primary biliary cholangitis and partially restored after UDCA therapy [2017] [Gut] [Journal] [80000594 ]
[1.133 ] Fungi participate in the dysbiosis of gut microbiota in patients with primary sclerosing cholangitis [2019] [Gut] [Journal] [80000990 ]
[1.134 ] Gut microbiota dysbiosis in a cohort of patients with psoriasis [2019] [British Journal of Dermatology] [Journal] [80001039 ]
[1.135 ] Altered gut microbiota in Rett syndrome [2016] [Microbiome] [Journal] [80000534 ]
[1.136 ] Analysis of gut mycobiota in first-episode, drug-naïve Chinese patients with schizophrenia: a pilot study [2020] [Behavioural Brain Research] [Journal] [80001250 ]
[1.137 ] Alterations of gut microbiome in the patients with severe fever with thrombocytopenia syndrome [2018] [Frontiers in Microbiology] [Journal] [80000848 ]
[1.138 ] Fecal microbiota signatures of adult patients with different types of short bowel syndrome [2017] [Journal of Gastroenterology and Hepatology] [Journal] [80000662 ]
[1.139 ] Intestinal microbiome analysis revealed dysbiosis in sickle cell disease [2018] [American Journal of Hematology] [Journal] [80000719 ]
[1.140 ] Altered mucosal microbiome diversity and disease severity in Sjögren Syndrome [2016] [Scientific Reports] [Journal] [80000347 ]
[1.141 ] Dysbiosis of gut microbiota is associated with serum lipid profiles in male patients with chronic traumatic cervical spinal cord injury [2019] [American Journal of Translational Research] [Journal] [80001108 ]
[1.142 ] Dysbiosis of gut microbiota and short-chain fatty acids in acute ischemic stroke and the subsequent risk for poor functional outcomes [2020] [Research] [Journal of Parenteral and Enteral Nutrition] [Journal] [80001423 ]
[1.143 ] Association of systemic sclerosis with a unique colonic microbial consortium [2016] [Arthritis & Rheumatology] [Journal] [80000333 ]
[1.144 ] Dysbiosis of gut microbiota with reduced tremethylamine-N-oxide level in patients with large-artery atherosclerotic stroke or transient ischemic attack._DUBLICATE [2015] [Journal of the American Heart Association] [Journal] [80000456 ]
[1.145 ] Dysbiosis in the gut bacterial microbiome of patients with Uveitis, an inflammatory disease of the eye [2018] [Indian Journal of Microbiology] [Journal] [80000796 ]
[1.146 ] Faecal microbial dysbiosis in children with Wiskott-Aldrich syndrome [2020] [Journal of Immunology] [Journal] [80001296 ]
[1.147 ] Long-term daily high-protein, drained yoghurt consumption alters abundance of selected functional groups of the human gut microbiota and fecal short-chain fatty acid profiles in a cohort of overweight and obese women [2022] [Cohort study] [Journal of Functional Foods] [Journal] [80002459 ]
[1.148 ] Family SES Is Associated with the Gut Microbiome in Infants and Children [2021] [Cohort study] [Microorganisms] [Journal] [80002079 ]
[1.149 ] Rethinking healthy eating in light of the gut microbiome [2022] [Review] [Cell Host & Microbe] [Journal] [80002441 ]