Microbiome & Chronic Diseases

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Ruminococcaceae ⇒ Faecalibacterium {10000187}

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Initialisation date:


Meta Information

Zone:[  ]
Enzyme:[  ]
Mucin-degrading, Anti-inflammatory, Fatigue-inducing


- Short chain fatty acid producer

References Notes

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Shared Reference Notes

  • [1.108
    - Reduced abundance of Faecalibacterium was found to be predictive of RA and this bacterium was found to be significantly positively correlated with a number of metabolites including the vitamin B metabolites riboflavin, nicotinate and pantothenate; nucleotides adenine, guanine and uracil; and the SCFA butyrate. - As a butyrate producer, Faecalibacterium is generally considered beneficial
  • [1.109] [#Autism
    - Increase in Faecalibacterium in ASD children is responsible for the progression of inflammatory processes, with increased levels of type I interferon, and the alteration of the intestinal barrier.
  • [1.110] [#Alzheimer’s disease
    - Increasing the relative abundance of #Bacteroides and Faecalibacterium may improve cognitive levels
  • [1.111] [#Diabetes Type 2, #Obesity] [#Gender, #Resistant starch
    - gut microbiota, especially Faecalibacterium, Predict postprandial glucose response (PPGR) after eating potatoes.
  • [1.34] [#Chronic fatigue syndrome, #Inflamatory bowel disease, #Multiple Sclerosis
    - MC/CFS > a reduction of Faecalibacterium was also found in IBD patients with fatigue (compared to IBD patients without fatigue), , #Cancer-related fatigue (compared to #Cancer patients with low fatigue) and other autoimmune diseases such as MS and #Diabetes Type 1 .
  • [#Chronic fatigue syndrome] - MC/CFS > microbiome alterations that were consistent with an increased inflammation of the gut, namely significantly increased #Lactonifactor and #Alistipes - in particular an increase of #Alistipes and a decrease of butyrate-producer Faecalibacterium were considered as top biomarkers with potential diagnostic value - abundance of #Bifidobacterium and Faecalibacterium to be reduced in the affected twin compared to the non-affected one. - Decreases in Faecalibacterium and increases in #Coprobacillus were found. - Gut abundances of #Coprobacillus, of #Eggerthella and #Blautia were best able to distinguish patients from controls. - Decreases in Faecalibacterium and increases in #Coprobacillus were found. - distinct microbial pattern with decreased anti-inflammatory #Firmicutes
  • [1.62] [#Infectious diarrhea
    - A drastic disappearance of obligate anaerobic gut commensals (#Blautia, #Prevotella, Faecalibacterium, #Lachnospiraceae, #Ruminococcaceae, etc.), leading to a depletion of associated metabolites such as #Short Chain Fatty Acid (SCFAs)
  • [1.78] [#Parkinson’s Disease
    - #Prevotellaceae (Prevotella), #Ruminococcaceae (Faecalibacterium), #Lachnospiraceae (#Blautia, #Roseburia) that produce SCFA and help in the synthesis of mucin to maintain the intestinal integrity are considerably lower in abundance in PD
  • [1.107
    - Decreases in SCFA-producing bacteria, specifically belonging to #Akkermansia and Faecalibacterium genera, have also been detected in mice subject to 7-day paradoxical #Sleep Deprivation and 3-day continuous #Sleep Deprivation. - Decreases in Bifidobacterium and Lactobacillus genera have been seen in mice subject to 5 days of sleep disruption. - #Sleep Deprivation–induced dysbiosis in mice resulted in increased intestinal permeability and reduced abundance of SCFAs, features that were both reversed following subsequent administration of #Lactobacillus plantarum.
  • - patients with psoriasis report a relative reduction in intestinal abundance of #Akkermansia, #Ruminococcus, or Faecalibacterium genera, which are all comprised of mucin-degrading SCFA-producing commensals.
  • [1.89
    -The antibacterial and antitumor defensin (HBD1) showed decreased levels in #Prostate cancer patients, while others (HBD2 and 3) were considerably increased. - Abundance of #Staphylococcus, #Corynebacterium and #Oxyphotobacteria genera was significantly higher, the abundance of Faecalibacterium and #Bacteroides genera were significantly lower in prostate tumor samples compared to non-tumor samples. - #Bacteroides, Parabacteroides and Faecalibacterium abundance gradually decreased with the combined increase in HBD2 and HBD3. - Higher #Corynebacterium and #Staphylococcus abundances were measured together with higher HBD2 and HBD3 urinary levels.
  • [1.112] [#Asthma] [#Children
    - low α-diversity and relative abundance of particular gut-commensal bacteria genera (#Bifidobacterium, Faecalibacterium, #Ruminococcus, and #Roseburia) are associated with childhood respiratory diseases.
  • [1.113
    - the intestines and colon are enriched with anaerobes including the #Clostridium and Faecalibacterium genera.
  • [1.106] [#Clostridium difficile associated disease] [#Administration of Vancomycin
    - vancomycin is used for C. difficile (CDI) which is associated with decrease in number of gut microbes like #Bacteroidetes, #Fuminococcus, and Faecalibacterium and increases in #Proteobacteria species.
  • [1.103
    - At the genus level, #Prevotella and #Bacteroides were significantly enriched in the #Meditation group. - Two beneficial bacterial genera (#Megamonas and Faecalibacterium) were significantly enriched in the #Meditation group. - Several pathways—including glycan biosynthesis, metabolism and lipopolysaccharide biosynthesis—were significantly enriched in the #Meditation group. - Plasma levels of clinical risk factors were significantly decreased in the #Meditation group, including total #Cholesterol and apolipoprotein B.
  • [1.114] [#Bipolar disorder, #Depression
    - Depressive stages in BD patients manifested in form of melancholia are associated with higher IgA responses to #Citrobacter koseri than in healthy or non-melancholic depressed individuals. - - in BD patients with a depressive episode > increased levels of #Coriobacteria and #Actinobacteria together with decreased #Ruminococcaceae and Faecalibacterium.

Common References