Disease ⇒ Postmenopausal {40000277}

Shared Reference Notes

• [1.1] 
  - #Estradiol-degrading #Klebsiella aerogenes from the feces of premenopausal females with #Depression > In mice, gavaging with this strain led to #Estradiol decline and #Depression-like behaviors. - The gene encoding the #Estradiol-degrading enzyme in K. aerogenes was identified as 3β-hydroxysteroid dehydrogenase (3β-HSD). - The prevalence of K. aerogene and 3β-HSD was higher in premenopausal women with #Depression than in those without #Depression.
• [1.2] [#Osteoporosis] [#humanized Galactooligosaccharides] 
  - the prebiotic galactooligosaccharides (GOS) promotes the growth of #Bifidobacteria which increases calcium absorption and prevents bone loss and enhances calcium absorption and inhibits bone resorption in postmenopausal women
• - Gut #Bacteria that possess β-glucuronidase and/or β-galactosidase activity can metabolize #Estrogen including #Bifidobacterium, #Faecalibacterium, #Lactobacillus, #Veillonella
• [1.3] [#Bifidobacteria] [#Phenol] 
  - a bifidogenic effect was observed following the consumption of #Cranberry juice (providing 161 mg of (poly)phenols and an unreported amount of oligosaccharides) for 15 days in 10 postmenopausal women
• [1.4] [#Menopause] [#High Fat Diet] 
  - ovariectomy led to greater gastrointestinal permeability and inflammation of the gut and metabolic organs, and that a high-fat diet exacerbated these phenotypes. - Ovariectomy also led to alteration of the gut microbiome, including greater fecal β-glucuronidase activity. - differential changes in the gut microbiome only occurred when fed a low-fat diet, not the high-fat diet. - Gnotobiotic mice that received the gut microbiome from ovariectomized mice fed the low-fat diet had greater weight gain and hepatic gene expression related to metabolic dysfunction and inflammation than those that received intact sham control-associated microbiome.

References Notes