Microbiome & Chronic Diseases

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Disease ⇒ Depression ⇒ Severe Mental Disorders {40000114}

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Initialisation date:
Other Terms:
Depressive Disorders, major depressive disorder, MDD


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References Notes

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Shared Reference Notes

  • [1.3
    - One previously uncultured bacterium, provisionally named Evtepia gabavorous KLE1738, which required the presence of Bacteroides fragilis KLE1758 for growth. Using bio-assay driven purification of B. fragilis supernatant, Gama-aminobutyric acid (GABA), the major inhibitory neurotransmitter of the mammalian central nervous system, was identified as the growth factor of E. gabavorous. In vitro feeding experiments and genomic analysis of E. gabavorous suggests an unusual metabolism focused on consuming GABA. - Using growth of E. gabavorous as an indicator. Reduced levels of GABA are associated with depression, and we found fewer GABA producers in a human cohort of depressed, bipolar, and/or schizophrenic individuals. By modulating the level of GABA, microbial producers and consumers of this neurotransmitter may be influencing host.
  • [1.12
    - GABA is the growth factor produced by Bacteroides fragilis. - An inverse relationship between the relative abundance of fecal Bacteroidesand functional connectivity in a part of the brain associated with elevated activity during depression. This means that low abundance of Bacteroides was associated with high activity in that part of the brain, and vice versa.
  • [1.5
    - There is a decrease in the endocannabinoid (eCB) signaling due to lower peripheral levels of fatty acid precursors of eCB ligands. - The adverse effects of UCMS-transferred microbiota is alleviated by selectively enhancing the central eCB or by complementation with a strain of the Lactobacilli genus.
  • [1.13
    - Chemogenetic activation of striatal microglia induces an aversive affective state - Chemogenetic inhibition of microglia blocks inflammation-induced aversion - Microglial interleukin 6 signaling and prostaglandin synthesis regulate affective state - Prostaglandin E2 from activated microglia reduces the excitability of striatal neurons
  • [1.14
    - It is found that the transfer of the microbiota from models with depression to that of other animals deprived of their microbiota also determined the transfer of the behavioral and physiological characteristics of the depression
  • - Butyrate reduced the depressive behavior, exerting an effect on the CNS in rats
  • [#Probiotic (Bifidobacter and Lactobacilus)] - The administration of a probiotic cocktail, composed of #Lactobacillus rhamnosus and #Lactobacillus helveticus, reduced the symptoms of depression and anxiety
  • [1.15
    - #Combination of probiotics and polyphenol-rich prebiotics, a synbiotic >attenuates the chronic-stress induced inflammatory responses in the ileum and the prefrontal cortex promoting > resilience to the consequent depressive- and #Anxiety-like behaviors in male mice. - This effect may be attributed to specific synbiotic-produced metabolites including #4-hydroxyphenylpropionic, #4-hydroxyphenylacetic acid and #Caffeic acid > promoted anti-inflammatory activity through the aryl hydrocarbon receptor (AHR).
  • [1.11] [#Lactobacillaceae] [#Probiotic (Bifidobacter and Lactobacilus)
    - #Lactobacillus reuteri and #Bifidobacterium adolescentis Probitica > reduction in depressive symptoms at four and eight weeks of treatment, and #Anxiety symptoms at four weeks. > improvement in #Sleep quality. - #Lactobacillus reuteri and #Bifidobacterium adolescentis Probitica > decrease in serum interleukin-6 levels. - #Lactobacillus reuteri and #Bifidobacterium adolescentis Probitica > increased #Bifidobacteriaceae and Lactobacillacea, whereas it decreased #Enterobacteriaceae in the gut microbiota composition.
  • [1.6
    - #Morganella, was significantly increased in a microbial survey of the 181 people in the study who later developed depression.
  • [1.8
    - depression > glutamate and acetylcholine neurotransmitter levels are higher, while GABA neurotransmitter levels are lower. - regulation of the Kyn/tryptophan pathway may affect the receptors of NMDA in the CNS, might be involved in the progression of depression
  • [1.16] [#Inflamatory bowel disease
    - patients with depression were two times as likely to develop IBD. - 30% of inflammatory bowel disease (IBD) patients develop depression.
  • [1.17] [#Short Chain Fatty Acid
    - reduced levels of SCFAs were observed in patients with #Alzheimer’s disease, and they also promoted depression-like behaviors and impairments of short-term memory in mice
  • - #kynurenine and #Indole derivatives might be associated with neurogenic depression
  • [1.2
    - Oral gavages of #Klebsiella oxytoca, #Escherichia coli, and #Cronobacter sakazakii belonging to Enterobacteriaceae, singly or together, caused dose-dependently #Colitis and depression-like behaviors in germ-free and specific-pathogen-free mice.
  • - #Enterococcus faecium and #Pediococcus acidolactici did not significantly cause colitis and depression-like behaviors, they significantly deteriorated Klebsiella oxytoca- or Escherichia coli-induced colitis, neuroinflammation, and anxiety/depression-like behaviors and increased blood LPS, corticosterone, and IL-6 levels.
  • [1.4] [#Lactobacillus plantarum
    - High #Proline consumption was the dietary factor with the strongest impact on depression. - #Proline supplementation in mice exacerbated depression along with microbial translocation. - RNAi-mediated knockdown of #Proline and GABA transporters in Drosophila and mono-association with L. plantarum, a high GABA producer, conferred protection against depression-like states.
  • [1.10] [#Vitamin B12
    - The neurologic complications of B12 deficiency occur at a later stage of depletion and was associated with severe symptoms of depression, suicidal behaviors, reduced cognition, mental #Fatigue, bad or depressed moods, mania, psychosis, and intense agitation
  • [#Dark chocolate] - #Blautia obeum levels were significantly elevated and #Faecalibacterium prausnitzii levels were reduced in DC85 compared to CON (P<.05). - Mood states were measured using the Positive and Negative Affect Schedule (PANAS) - the observed changes in negative affect scores were negatively correlated with diversity and relative abundance of #Blautia obeum.
  • [1.18] [#Suicidal ideation
    - rs10437629, previously associated with attempted suicide, was correlated here with SI and the absence of #Alloprevotella rava, a producer of an organic acid known to promote brain energy homeostasis.
  • [1.19
    - Serum IL-6 (age 9) strongly associated with total number of depressive episodes. - CRP DNAm scores weakly associated with total number of psychotic experiences.
  • [1.7] [#5-Hydroxytryptophan
    - Oral administration of 5-HTP significantly restored gut microbiota dysbiosis in mice with depression-like behaviors
  • - Lactobacillus rhamnosus reduce stress-induced corticosterone and anxiety- and depression-related behavior.
  • [1.9
    - Researchers identified two bacterial genera " Coprococcus and Dialister " were depleted in patients with depression whether or not they were taking antidepressants.

Common References