Sleep {51111254}

Shared Reference Notes

• [1.1] 
  - on awakening than before sleep > higher relative abundance of Prevotella and Corynebacterium in all locations of the oral cavity. - on awakening than before sleep > different Rothia levels depending on location.
• [1.2] 
  - “#Bifidobacterium” pattern > increaseds sleep Activity at 12 months. - “#Bifidobacterium” enterotype > infants with more nighttime awakenings.
• - infants with higher alpha diversity > exhibited less predominant daytime sleep. - infants with more mature gut microbiome > more activity and awakenings at nighttime.
• [1.3] [#Depression] [#Lactobacillaceae, #Limosilactobacillus (Lactobacillus) reuteri] [#Probiotic (Bifidobacter and Lactobacilus)] 
  - Lactobacillus reuteri and #Bifidobacterium adolescentis Probitica > reduction in depressive symptoms at four and eight weeks of treatment, and #Anxiety symptoms at four weeks. > improvement in sleep quality. - Lactobacillus reuteri and #Bifidobacterium adolescentis Probitica > decrease in serum interleukin-6 levels. - Lactobacillus reuteri and #Bifidobacterium adolescentis Probitica > increased #Bifidobacteriaceae and Lactobacillacea, whereas it decreased #Enterobacteriaceae in the gut microbiota composition.
• [1.4] [#Alzheimer’s disease] [#Amyloid-beta] 
  - levels of Aβ are increased when mice and human are awake and decrease when they are asleep. - These diurnal oscillations in Aβ levels in brain ISF are dissipated and the sleep–wake cycle is disrupted after Aβ plaque formation in the APP/PS1 mouse model of amyloidosis. - amelioration of Aβ plaque pathology with Aβ immunotherapy restored a normal sleep wake cycle and diurnal oscillations in Aβ levels in the mice. - Lower neuronal activity during sleep likely leads to less Aβ production.
• [#Alzheimer’s disease] [#Sleep Deprivation] - Sleep deprivation exacerbates AD pathology, which clearly connects poor sleep quality with progression of AD.
• - Administration of #Butyrate promote NREM sleep in rats and mice. - Sleep disruption can lead to changes in Gut Microbiota composition > tissue inflammation and decreased insulin sensitivity.
• [#Narcolepsy] - #Insomnia and narcoleptic patients both have altered Gut Microbiota composition
• [#Obstructive sleep apnea-hypopnea syndrome] - Intermittent hypoxia associated with obstructive sleep apnea (OSA) is associated with Gut Microbiota composition and diversity changes.
• [#Short Chain Fatty Acid] [#Infants] - a higher percentage of #Propionate in relation to total SCFA composition was associated with longer uninterrupted human infant sleep
• [1.5] 
  - it seems to exist a negative correlation between #Lactobacillus and #Bifidobacterium counts with sleep and cortisol levels respectively
• [1.6] 
  - #Melatonin administration in animals helped reduce dysbiosis due to sleep restriction. - In one of the studies, #Akkermansia muciniphila and #Lactobacilli species were increased in the #Melatonin-treated animals.
• [1.7] [#Cognitive impairment] [#Lactobacillus plantarum] 
  - Intake of Lactiplantibacillus plantarum LPHEAL9 significantly improved cognitive functions compared to the placebo, potentially by ameliorating aspects of mood and sleep.
• [1.8] [#Alzheimer’s disease] [#Amyloid-beta] [#Fasting] 
  - TRF (time-restricted feeding) had the remarkable capability of simultaneously reducing #Amyloid deposition, increasing Aβ42 clearance, improving sleep and memory, and normalizing daily transcription patterns of multiple genes, including those associated with AD and neuroinflammation. - TRF had a major impact on neuropathology, with treated APP23 TG mice displaying a significant reduction in plaque burden and #Amyloid deposition and a reversal of circulating biomarkers of AD. - TRF protocol was effective in reducing #Amyloid burden and improving memory in the APP knockin (APP-KI) mouse model.
• [#Fasting] - time-restricted feeding (TRF; 6 h feed, 18 h fast cycles) can improve sleep/wake cycles, motor performance, and inflammation in mouse models of #Huntington’s Disease.
• [1.9] [#Multiple Sclerosis] 
  - #Tryptamine is a neuromodulator with antioxidant characteristics that is produced when commensal bacteria break down #Tryptophan. - Deficits in #Tryptophan-derived #Neurotransmitters like #Serotonin and #Melatonin, which are both essential for sleep, are frequently linked to MS comorbidities, including #Depression
• [#Intermittent Hypoxia, #Obstructive sleep apnea-hypopnea syndrome] - gut microbiome changes associated with IH can independently cause sleep disturbances in mice. - The sleep disorders observed in mice resemble the excessive daytime sleepiness commonly found in individuals with OSA.
• [#Obstructive sleep apnea-hypopnea syndrome] [#GABA] - #Actinobacteria were significantly downregulated in OSA. - #Actinobacteria are renowned for producing the sleep-inducing neurotransmitter gamma-aminobutyric acid. - a negative correlation was observed between #Actinobacteria and the number of awakenings in healthy individuals

References Notes