Disease ⇒ Huntington’s Disease {40000471}

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Huntington’s Disease


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Shared Reference Notes

  • [1.1] [#Parkinson’s Disease] [#Escherichia coli
    - E. coli genes promote neurodegeneration. - Two of these genes, csgA and csgB, code for proteins that form #Curli, one type of bacterial amyloid fibers. - #Curli cross-seeds and colocalizes with α-syn both in C. elegans neurons and human neuroblastoma cells. - #Curli-induced α-syn aggregations down-regulate mitochondrial genes, causing energy failure in neurons. - #Curli may have general effects in promoting neuropathologies induced by different aggregation-prone proteins, such as A-β in #Alzheimer’s disease, Huntingtin in Huntington’s disease, and SOD1 in #Amyotrophic lateral sclerosis.
  • [1.2] [#Fecal Microbiota Transplantation
    - faecal microbiota transplant (FMT) from wild-type into Huntington’s disease mice positively modulates cognitive outcomes in Huntigton’s Disease model, particularly in females.
  • [1.3] [#Indole-3-propionic acid
    - The plasma levels of IPA are significantly lower in subjects with Huntington’s disease compared to healthy controls
  • [1.4] [#Lactobacillus rhamnosus
    - Lacticaseibacillus rhamnosus HA-114 is neuroprotective in C. elegans models of #Amyotrophic lateral sclerosis and Huntington’s disease. - neuroprotection from L. rhamnosus HA-114 is unique from other L. rhamnosus strains and resides in its fatty acid content. - dietary intervention with L. rhamnosus HA-114 restores lipid homeostasis and energy balance through mitochondrial β-oxidation.
  • [1.5] [#Alzheimer’s disease, #Amyotrophic lateral sclerosis
    - extracellular #Glutamate leads to excitotoxicity in vitro and in vivo in astrocytes and neurons through the overactivation of ionotropic #Glutamate receptors. - Chronic excitotoxicity is hypothesized to play a role in numerous neurodegenerative disorders, including AD, ALS, and Huntington’s disease
  • [1.6] [#Fasting
    - time-restricted feeding (TRF; 6 h feed, 18 h fast cycles) can improve #Sleep/wake cycles, motor performance, and inflammation in mouse models of Huntington’s disease.

References Notes

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