Disease ⇒ Huntington’s Disease {40000471} Record Keys Type:Disease Parent:[ ] Definition:Huntington’s Disease Details Initialisation date:[ ] Other Terms:HD Meta Information MedDra ID:10070668 MedDra Level:pt ICD:[ ] Category:[ ] Zone:[ ] Mechanism:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Parkinson’s Disease] [#Escherichia coli] - E. coli genes promote neurodegeneration. - Two of these genes, csgA and csgB, code for proteins that form #Curli, one type of bacterial amyloid fibers. - #Curli cross-seeds and colocalizes with α-syn both in C. elegans neurons and human neuroblastoma cells. - #Curli-induced α-syn aggregations down-regulate mitochondrial genes, causing energy failure in neurons. - #Curli may have general effects in promoting neuropathologies induced by different aggregation-prone proteins, such as A-β in #Alzheimer’s disease, Huntingtin in Huntington’s disease, and SOD1 in #Amyotrophic lateral sclerosis. [1.2] [#Fecal Microbiota Transplantation] - faecal microbiota transplant (FMT) from wild-type into Huntington’s disease mice positively modulates cognitive outcomes in Huntigton’s Disease model, particularly in females. [1.3] [#Indole-3-propionic acid] - The plasma levels of IPA are significantly lower in subjects with Huntington’s disease compared to healthy controls [1.4] [#Lactobacillus rhamnosus] - Lacticaseibacillus rhamnosus HA-114 is neuroprotective in C. elegans models of #Amyotrophic lateral sclerosis and Huntington’s disease. - neuroprotection from L. rhamnosus HA-114 is unique from other L. rhamnosus strains and resides in its fatty acid content. - dietary intervention with L. rhamnosus HA-114 restores lipid homeostasis and energy balance through mitochondrial β-oxidation. [1.5] [#Alzheimer’s disease, #Amyotrophic lateral sclerosis] - extracellular #Glutamate leads to excitotoxicity in vitro and in vivo in astrocytes and neurons through the overactivation of ionotropic #Glutamate receptors. - Chronic excitotoxicity is hypothesized to play a role in numerous neurodegenerative disorders, including AD, ALS, and Huntington’s disease [1.6] [#Fasting] - time-restricted feeding (TRF; 6 h feed, 18 h fast cycles) can improve #Sleep/wake cycles, motor performance, and inflammation in mouse models of Huntington’s disease.References Notes[ ]
