Microbiome & Chronic Diseases

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Saccharomycetales ⇒ Candida {10001442}

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Shared Reference Notes

  • [1.1
    - The metabolites of Candida is related with different metabolic pathways, such as amino acid metabolism and biosynthesis, fatty acids metabolism, aromatic compounds degradation, mono and sesquiterpenoid synthesis and carotenoid cleavage
  • [1.2] [#Chronic Obstructive Pulmonary Disease
    - The oral and pulmonary mycobiomes from controls and participants with COPD were dominated by Candida - Malassezia and Sarocladium were also frequently found in pulmonary samples.
  • [1.3
    - There is an expansion of Candida sp. and Rhodotorula sp. in stool samples from US infants that later developed #Atopy.
  • [1.4] [#Crohn’s disease] [#Candida albicans, #Candida glabrata, #Candida tropicalis
    - Candida. A common, although not universal, finding has been an increase, statistically significant or trending, in the relative amount of Candida in the fecal mycobiome of patients with CD from diverse geographic locations. - The named species is usually C. albicans, but C. tropicalis and C. glabrata have also been reported.
  • [1.5] [#Adult
    - Multiple Candida spp. were at higher relative abundance in #Children than adults, while #Malassezia and certain food-associated fungi were lower in #Children.
  • [1.6] [#Fecal Microbiota Transplantation
    - In #Ulcerative Colitis (UC), patients’ mycobiota revealed that those with high levels of Candida were more likely to benefit from FMT treatment. - Amelioration of disease was associated with a decrease in Candida following FMT.
  • [1.7] [#Gastric carcinoma
    - Candida and #Alternaria were enriched in GC, while Saitozyma and Thermomyces were GC-depleted
  • [1.8] [#Helicobacter pylori
    - Streptococcus, Neisseriae, Prevotella, Rothia, Fusobacterium, Veillonella, and Haemophilus are considered the main gastric bacterial genera enriched in #H. pylori-positive individuals. - the overgrowth of Candida species in the stomach has been reported during H. pylori infection, which might result in synergistic effects on the H. pylori pathogenesis.
  • [1.9] [#Colorectal cancer
    - in colon cancers Candida > predictive of metastatic disease and attenuated cellular adhesions. - Candida DNA is enriched in tumors and predictive of reduced survival in GI cancers
  • [#Stomach cancer] - In stomach cancers, high rates of Candida were linked to the expression of pro-inflammatory immune pathways
  • [#Amyotrophic lateral sclerosis] - Tissue sections from different regions of the CNS of ALS patients contain fungi. - fungal structures such as yeast and hyphae in the motor cortex, the medulla and the spinal cord, in eleven patients with ALS. - Some fungal structures were localized intracellularly and even intranuclearly, indicating that this infection is not the result of post-mortem colonization. - PCR analysis and next generation sequencing of DNA extracted from frozen neural tissue identified a variety of fungal genera including Candida, #Malassezia, #Fusarium, #Botrytis, #Trichoderma and #Cryptococcus.
  • [1.11] [#Oral lichen planus
    - Higher enrichment of the fungi Candida and #Aspergillus was identified in patients with reticular OLP than in healthy controls.
  • [1.12] [#Antibiotic Therapy
    - Antibiotic-treatment was observed to enrich fungi such as Candida and #Saccharomyces
  • [1.13] [#Multiple Sclerosis
    - In MS, the gut mycobiome differs from that of healthy individuals, with enrichment of Candida and #Epicoccum as well as a lower relative abundance of #Saccharomyces.
  • [1.14
    - Candida-infected individuals had 2.3 times more dental #Caries than those without Candida in their oral cavity
  • [1.15] [#Autism
    - reduced #D-arabinitol levels, a metabolite of Candida species, in the urine of #Children with ASD after #Probiotic supplementation
  • [#Probiotic] - probiotics may prevent gastrointestinal colonization by Candida species
  • [1.16] [#Streptococcus gordonii, #Streptococcus mitis, #Streptococcus oralis, #Streptococcus salivarius, #Streptococcus sanguinis] [#Alcohol Consumption
    - Several oral microbial species such as #Streptococci S. gordonii, S. mitis, S. oralis, S. salivarius, S. sanguinis, and Candida yeasts possess the enzyme alcohol dehydrogenase (ADH), which metabolizes alcohol to #Acetaldehyde, which is indisputably carcinogenic.
  • [1.17] [#Gastric bypass surgery
    - Roux-en-Y gastric bypass (RYGB) resulted in clear alteration in composition of gut fungal and bacterial microbiota. - Before surgery, patients had higher levels of #Firmicutes and #Actinobacteria and lower levels of #Verrucomicrobia - #Faecalibacterium and #Bifidobacterium showed a decrease after surgery and aerotolerant #Streptococcus was increased postoperatively. - The relative abundance of #Proteobacteria was increased after surgery. - Changes in fungal microbiota composition included decreases in Candida and #Saccharomyces and increases in #Pichia. - levels of #Verrucomicrobia and #Proteobacteria increased after the surgery procedure - Bifidobacteriaceae abundance decreased, whereas Streptococcaceae and Enterobacteriaceae increased after surgery. - RYGB led to increased #Firmicutes and #Actinobacteria phyla but decreased #Bacteroidetes phylum

References Notes

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Common References