Disease ⇒ Oral squamous cell carcinoma {40000613}

Shared Reference Notes

• [1.1] [#Colorectal cancer] 
  - #Fusobacterium nucleatum has been implicated as a carcinogen in oral squamous cell carcinoma (OSCC) and CRC, with a demonstrated bacterial transcript load 400 times that of matched adjacent normal tissue
• [1.2] 
  - Oral cancer and epithelial precursor lesions are also linked with bacteria from genera #Fusobacterium, #Veillonella, #Actinomyces, #Clostridium, #Haemophilus, and #Enterobacteriaceae
• - specific bacteria have been identified that correlate strongly with Oral squamous cell carcinomas (OSCCs), such as #Streptococcus sp., #Peptostreptococcus sp., #Prevotella sp., #Porphyromonas gingivalis, and #Capnocytophaga gingivalis
• - most often observed oral bacteria in OSCCs are #Streptococcus sp., #Peptostreptococcus sp., #Prevotella sp., #Porphyromonas gingivalis, and #Capnocytophaga gingivalis
• - The levels of three species (#Capnocytophaga gingivalis, #Prevotella melaninogenica, and #Streptococcus mitis) were elevated in the saliva of patients suffering from OSCC.
• - OSCC tumor sites are highl associated with the following species: #Streptococcus sp., #Peptostreptococcus stomatis, #Gemella sp., and #Johnsonella ignava
• - most taxa isolated from within the tumor tissue of oral squamous cell carcinoma represent saccharolytic and aciduric species, mainly #Streptococci
• [1.3] 
  - the genera #Parvimonas, #Peptoniphilus and #Fusobacterium were most abundant in an #Oral cancer subtype, OSCC
• [1.4] 
  - Elevated #Methanethiol concentrations were also found in the exhaled breath of persons diagnosed with oral squamous cell carcinoma, probably deriving from the high endogenous synthesis in the tumor tissue.
• [1.5] 
  - #Pancreatic Cancer > the #Mannose-binding #Lectin, which binds specifically to the #Glycans on the fungal wall, was activated mainly by the #Malassezia genus, showing potential for tumor formation. - the presence of #Malassezia sp. in OSCC is associated with a favorable prognosis
• - The progression of OSCC is marked by a significant increase in the presence of #Acremonium and #Aspergillus, both known for their detrimental health effects
• [#Candida dubliniensis] - patients with OSCC > oral rinse samples from individuals without cancer showed a higher prevalence of C. dubliniensis, Schizophyllum commune, and organisms belonging to the #Agaricomycetes class
• [#Candida albicans] - overgrowth of C. albicans in OSCC tissue
• [#Candida albicans] - patients with OSCC > #Candida species were identified in 74% of the samples, with C. albicans being the predominant species in 84%
• - #Verruconis gallopava, #Dimargaris cristalligena, and #Syncephalastrum racemosum, were found to be more frequently present in OSCC lesions and linked to opportunistic infections.
• - #Lichteimia corymbifera showed an association with OSCC of the tongue
• - #Paracoccidioides brasiliensis, a fungal yeast causing paracoccidioidomycosis leading to oral manifestations, has been associated with OSCC
• [1.6] 
  - oral cavity squamous cell carcinoma (OSCC) > enrichment in the relative abundance of seven bacteria species (#Fusobacterium nucleatum, #Treponema medium, #Peptostreptococcus stomatis, #Gemella morbillorum, #Catonella morbi, #Peptoanaerobacter yurli and #Peptococcus simiae) were observed in OSCC tumor microenvironment. - pathogenic bacteria to regulate gene expression, in part, through epigenetic alterations.
• - oral cavity squamous cell carcinoma (OSCC) > #Fusobacterium nucleatum might contribute to cellular invasion via crosstalk with #E-cadherin/β-catenin signaling, TNFα/NF-κB pathway and extracellular matrix remodeling by up-regulating SNAI2 gene, a key transcription factor of epithelial-mesenchymal transition (EMT).

References Notes