Disease ⇒ Oral squamous cell carcinoma {40000613} Record Keys Type:Disease Parent:[ ] Definition:Oral squamous cell carcinoma Details Initialisation date:[ ] Other Terms:[ ] Meta Information MedDra ID:[ ] MedDra Level:[ ] ICD:[ ] Category:[ ] Zone:[ ] Mechanism:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Colorectal cancer] - #Fusobacterium nucleatum has been implicated as a carcinogen in oral squamous cell carcinoma (OSCC) and CRC, with a demonstrated bacterial transcript load 400 times that of matched adjacent normal tissue [1.2] - Oral cancer and epithelial precursor lesions are also linked with bacteria from genera #Fusobacterium, #Veillonella, #Actinomyces, #Clostridium, #Haemophilus, and #Enterobacteriaceae - specific bacteria have been identified that correlate strongly with Oral squamous cell carcinomas (OSCCs), such as #Streptococcus sp., #Peptostreptococcus sp., #Prevotella sp., #Porphyromonas gingivalis, and #Capnocytophaga gingivalis - most often observed oral bacteria in OSCCs are #Streptococcus sp., #Peptostreptococcus sp., #Prevotella sp., #Porphyromonas gingivalis, and #Capnocytophaga gingivalis - The levels of three species (#Capnocytophaga gingivalis, #Prevotella melaninogenica, and #Streptococcus mitis) were elevated in the saliva of patients suffering from OSCC. - OSCC tumor sites are highl associated with the following species: #Streptococcus sp., #Peptostreptococcus stomatis, #Gemella sp., and #Johnsonella ignava - most taxa isolated from within the tumor tissue of oral squamous cell carcinoma represent saccharolytic and aciduric species, mainly #Streptococci [1.3] - the genera #Parvimonas, #Peptoniphilus and #Fusobacterium were most abundant in an #Oral cancer subtype, OSCC [1.4] - Elevated #Methanethiol concentrations were also found in the exhaled breath of persons diagnosed with oral squamous cell carcinoma, probably deriving from the high endogenous synthesis in the tumor tissue.References Notes[ ]
