Disease ⇒ Cancer ⇒ Oral cancer {40000278} Record Keys Type:Disease Parent:Cancer Definition:Oral cancer Details Initialisation date:[ ] Other Terms:[ ] Meta Information MedDra ID:10024535 MedDra Level:pt ICD:[ ] Category:[ ] Zone:[ ] Mechanism:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Colorectal cancer, #Thyroid carcinoma] [#Hydrogen sulfide] - H2S at a safe and nontoxic concentration can protect not only healthy cells, such as neurons, but also cancerous cells from apoptosis. - In a variety of cancers, including #Ovarian cancer, oral cancer, thyroid cancer, colon cancer, #Breast cancer, etc., the upregulation of H2S-producing enzyme CBS > can enhance the proliferation ability of cancer cells and make cancer cells more sensitive to it [1.2] - #Parvimonas micra, #Haemophilus influenzae, #Fusobacterium periodonticum, #Streptococcus constellatus, and #Filifactor alocis progressively increased with oral cancer development. - The abundance of dominant genera such as #Fusobacteria increased with cancer development, the abundance of Haemophilus, Streptococcus, Actinomyces, and Porphyromonas decreased. [#Porphyromonas gingivalis] - P. gingivalis, a critical pathogen in periodontal disease, is a significant trigger agent for oral cancer, and its colonization in tumor tissues is correlated with poor survival in patients with carcinoma [1.3] [#Esophageal cancer, #Head & Neck cancer] - Among streptococci, #Streptococcus anginosus seems to be an especially relevant marker of head, neck, and esophageal cancers [#Streptococcus constellatus, #Streptococcus mitis, #Streptococcus oralis, #Streptococcus salivarius, #Streptococcus sanguis] - oral #Streptococci (#Streptococcus intermedius, S. constellatus, S. oralis, S. mitis, S. sanguis, S. salivarius) were the most common isolates from cervical lymph nodes in patients with oral cancer. - Among the anaerobic bacteria, #Peptostreptococcus spp. dominated [1.4] [#Oral squamous cell carcinoma] - the genera #Parvimonas, #Peptoniphilus and #Fusobacterium were most abundant in an oral cancer subtype, OSCC [1.5] [#Crohn’s disease, #Inflamatory bowel disease, #Ulcerative Colitis] - CD and UC, as subtypes of IBD, were also found to be potential risk factors for oral cavity cancer [1.6] - the proportion of #Prevotella in oral cancer tissue was larger than that in normal tissueReferences Notes[ ]
