Disease ⇒ Cancer ⇒ Ovarian cancer {40000541} Record Keys Type:Disease Parent:Cancer Definition:Ovarian cancer Details Initialisation date:2022-03-23 Other Terms:[ ] Meta Information MedDra ID:[ ] MedDra Level:[ ] ICD:[ ] Category:[ ] Zone:[ ] Mechanism:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Colorectal cancer, #Thyroid carcinoma] [#Hydrogen sulfide] - H2S at a safe and nontoxic concentration can protect not only healthy cells, such as neurons, but also cancerous cells from apoptosis. - In a variety of cancers, including ovarian cancer, #Oral cancer, thyroid cancer, colon cancer, #Breast cancer, etc., the upregulation of H2S-producing enzyme CBS > can enhance the proliferation ability of cancer cells and make cancer cells more sensitive to it [1.2] [1.3] [#Breast cancer, #Pancreatic Cancer] - Fungi were detected in 35 #Cancer types and were often intracellular. - 0%–25% of the tumors per #Cancer type to be positive for either β-glucan or Aspergillus staining. - fungal staining was mainly evident within #Cancer cells in pancreatic, breast, and ovarian #Cancer, it mostly localized to macrophages in #Melanoma and lung cancers [1.4] - distinct OC microbiome with general enrichment of several microbial taxa, including #Dialister, #Corynebacterium, Prevotella, and #Peptoniphilus in the OC cohort in all body sites excluding stool and omentum particularly in OC patients with adverse treatment outcomes compared to those without events. [1.5] [#Cervical cancer] [#Reactive Oxygen Species] - #Chlamydia spp. have been described in cervical and ovarian cancer > decrease p53 signaling and DNA damage response, in facilitating the pathogen’s intracellular replication, induction of ROS production and DNA damageReferences Notes[ ]
