Disease ⇒ Melanoma ⇒ Cancer {40000152}
Type: | Disease |
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Definition: | Melanoma |
Parent: |
Initialisation date: | 2020-09-06 |
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Other Terms: | Malignant melanoma |
MedDra ID: | [ ] |
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MedDra Level: | [ ] |
ICD: | [ ] |
Category: | Dermatology, Oncology |
Zone: | [ ] |
Mechanism: | [ ] |
Notes:
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References Notes
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Shared Reference Notes
- [1.1]
- Patients with an unfavorable gut microbiome (e.g., low diversity and high relative abundance of Bacteroidales) have impaired systemic and anti-tumor immune responses mediated by limited intratumoral lymphoid and myeloid infiltration and weakened antigen presentation capacity.
- The gut microbiome may modulate responses to anti PD-1 immunotherapy in melanoma patients.
- Patients with a favorable gut microbiome (e.g., high diversity and abundance of Ruminococcaceae/Faecalibacterium) have enhanced systemic and anti-tumor immune responses mediated by increased antigen presentation, and improved effector T cell function in the periphery and the tumor microenvironment. - [1.2]
- FMT and anti–PD-1 changed the gut microbiome and reprogrammed the tumor microenvironment to overcome resistance to anti–PD-1 in a subset of PD-1 advanced melanoma. - [1.3]
-Bifidobacterium emerged as strongly associated with T cell response, and consistently, oral administration of a cocktail of Bifidobacterium species combined with an anti-PD-L1 antibody nearly abolished the melanoma growth.
- Bifidobacterium longum, Collinsella aerofaciens, and Enterococcus faecium was associated with anti-PD1 efficacy in metastatic melanoma patients. (2) - [1.4]
- Higher dietary fiber > improved progression-free survival in 128 patients on immune checkpoint blockade (ICB) treatment, with the most pronounced benefit observed in patients with sufficient dietary fiber intake and no probiotic use.