Disease ⇒ Cancer ⇒ Lung cancer {40000372}

Shared Reference Notes

• [1.1] 
  - A greater abundance of Spirochaetia was associated with lower risk of cancer, and increased levels of Lactobacillales was linked to a heightened risk
• [1.2] 
  - Veillonella, Megasphaera, and Streptococcus > increased in lung cancer patients. - Neisseria, Staphylococcus, and Dialister > higher level in lung cancerous lesions than in normal lung tissues
• [1.3] [#Asthma, #Cystic fibrosis, #Pneumonia] 
• [1.4] 
  - every standard deviation increase in #Streptococcus abundance was associated with 1.14 times the risk of lung cancer
• [1.5] [#kynurenine, #Tryptophan] 
  - A high-serum Kyn/Trp ratio is also correlated with a poor prognosis after a PD-1 blockade in lung cancer, #Melanoma and #renal cell carcinomas
• [1.6] 
  - In lung cancer, #Blastomyces was associated with tumor tissues.
• [1.7] [#Streptococcus agalactiae, #Streptococcus salivarius] 
  - For non-small cell lung cancer patients, S. salivarius and S. agalactiae react upon gastrointestinal-derived CD4+ T cells and effectively activate monocytes to secrete higher levels of #IL-6, IL-12 and TNF, or so-called, the Th1- and Th17-skewed cytokines
• [1.8] [#Colorectal cancer, #Pancreatic Cancer] [#Veillonella atypica] 
  - #Veillonella genus is usually more abundant in treatment-naïve patients with lung, pancreatic (#Veillonella atypica) and colorectal #Cancer. - Furthermore, when comparing patients with advanced-stage #Cancer with and without weight loss, #Veillonella is more abundant in those who lost weight.
• [1.9] [#Fermented food] 
  - Fermented dairy intake was inversely associated with lung cancer risk
• [#Colorectal cancer, #Pancreatic Cancer] [#Veillonella atypica] - #Veillonella genus is usually more abundant in treatment-naïve patients with lung, pancreatic (#Veillonella atypica) and colorectal #Cancer.
• [1.11] 
  - Oral bacteria from genera #Capnocytophaga and #Veillonella are reportedly present in increased amounts in lung cancer patients
• [1.12] [#Smoking] 
  - most of the enriched taxa in the lung tumors of smokers belong to the #Proteobacteria phylum
• [#Smoking] - MetaCyc pathways responsible for the degradation of chemicals in cigarette smoke, such as toluene, acrylonitrile, and aminobenzoates, were significantly enriched in bacteria found in lung tumors compared with other tumor types
• [1.13] [#Escherichia coli] 
  - lung cancer, suggested that E. coli and #Staphylococcus aureus (S. aureus) may reside within these tumors
• [#Staphylococcus epidermidis] - S. epidermidis, #Haemophilus influenzae (H. influenza), and #Klebsiella pneumoniae (K. pneumoniae), were suggested to reside in lung cancer samples in separate studies
• [1.14] 
  - #Streptococcus and #Veillonella enrichment in lung cancer brushings have been associated with upregulation of phosphoinositide 3-kinases (PI3K); pPI3Ks, also known as phosphatidylinositol 3-kinases and extracellular signal-regulated kinase (ERK) pathways, are an enzyme group involved in cellular processes such cell growth, proliferation, differentiation, motility, survival, and intracellular trafficking that are proposed to have a role in promoting growth, migration, treatment resistance, and metastasis in most lung cancers.
• [1.15] 
  - enriched tumor-resident #Aspergillus sydowii in patients with lung adenocarcinoma (LUAD). - By three different syngeneic lung cancer mice models, we find that A. sydowii promotes lung tumor progression via IL-1β-mediated expansion and activation of MDSCs, resulting in suppressed activity of cytotoxic T lymphocyte cells and accumulation of PD-1+ CD8+ T cells.
• [1.16] [#Major depressive disorder, #Parkinson’s Disease] 
  - #Isoprene is involved in the mevalonate pathway of #Cholesterol synthesis. - decreased exhaled levels of #Isoprene have been detected in patients with lung cancer. - #Isoprene > a key role in cell membrane integrity, which has been linked to several neurologic and psychiatric disorders, such as #Schizophrenia and #Bipolar disorder, as well as Parkinson disease and #Multiple Sclerosis. - A possible neuroprotective function of #Isoprene might explain its absence in the breath of patients with #Schizophrenia and MDD, indicating a disturbance in neuroprotection in psychiatric disorders.

References Notes