Microbiome & Chronic Diseases

Evidence Based Medicine
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Disease ⇒ Asthma {40000140}

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References Notes

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Shared Reference Notes

  • [1.19
    - Differences in the fungal community were more strongly associated with asthma risk than bacterial dysbiosis.
    - Overrepresentation of total fungal sequences and an expansion of the yeast Issatchenkia orientalis in children who later developed symptoms
  • [1.20
    - Increased maternal dietary microbiome-accessible fiber and SCFA exposure during pregnancy > reduced incidence of asthma in offspring which persists into adulthood.
    - Reduced dietary fiber intake > reduced serum acetate levels in pregnant women > increased frequency of coughing/wheezing during the child’s first year of life.
    - During pregnancy > SCFA (such as acetate) > cross the placenta and affect the expression of fetal lung genes, such as NPPA, > encodes ANP (a molecule related to epithelial biology and immune regulation).
  • [1.21
    - Severe respiratory viral infection with respiratory syncytial virus (RSV) and rhinovirus (RV) is associated with increased risk of developing asthma, and as such, these viruses are considered asthmagenic.
    - Mice nasally exposed to two distinct strains of the commensal bacterial species Lactobacillus rhamnosus (LR05 and LR06) were protected against subsequent RSV infection.
    - Protection was associated with increased levels of IFN-β, IFN-γ, IL-6, and TNF-α in both BAL and serum samples, which contributed to viral clearance.
  • [1.24
    - siblings in the home to be one of the most important determinants of the developing microbiota in both the airway and gut, with significant differences in alpha diversity, beta diversity, and relative abundances of the most abundant taxa, with the specific associations being particularly apparent during the first year of life.
    - The age gap to the closest older sibling was more important than the number of older siblings. The signature of having siblings in the gut microbiota at 1 year was associated with protection against asthma at 6 years of age, while no associations were found for allergy.

Common References