Microbiome & Chronic Diseases

Evidence Based Medicine
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Disease ⇒ Asthma {40000140}

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References Notes

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Shared Reference Notes

  • [1.21
    - Differences in the fungal community were more strongly associated with asthma risk than bacterial dysbiosis. - Overrepresentation of total fungal sequences and an expansion of the yeast #Issatchenkia orientalis in children who later developed symptoms
  • [1.22] [#High-fiber diet
    - Increased maternal dietary microbiome-accessible fiber and SCFA exposure during pregnancy > reduced incidence of asthma in offspring which persists into adulthood. - Reduced dietary fiber intake > reduced serum #Acetate levels in pregnant women > increased frequency of coughing/wheezing during the child’s first year of life. - During pregnancy > SCFA (such as #Acetate) > cross the placenta and affect the expression of fetal lung genes, such as NPPA, > encodes ANP (a molecule related to epithelial biology and immune regulation).
  • [1.23] [#Cystic fibrosis, #Lung cancer, #Pneumonia
  • [1.24
    - Severe respiratory viral infection with respiratory syncytial virus (RSV) and rhinovirus (RV) is associated with increased risk of developing asthma, and as such, these viruses are considered asthmagenic. - Mice nasally exposed to two distinct strains of the commensal bacterial species Lactobacillus rhamnosus (LR05 and LR06) were protected against subsequent RSV infection. - Protection was associated with increased levels of IFN-β, IFN-γ, IL-6, and TNF-α in both BAL and serum samples, which contributed to viral clearance.
  • [1.25] [#Allergic asthma
  • [1.26
    - #Siblings in the home to be one of the most important determinants of the developing microbiota in both the airway and gut, with significant differences in alpha diversity, beta diversity, and relative abundances of the most abundant taxa, with the specific associations being particularly apparent during the first year of life. - The age gap to the closest older sibling was more important than the number of older #Siblings. The signature of having #Siblings in the gut microbiota at 1 year was associated with protection against asthma at 6 years of age, while no associations were found for #Allergy.
  • [1.27] [#Children
    - low α-diversity and relative abundance of particular gut-commensal bacteria genera (#Bifidobacterium, #Faecalibacterium, #Ruminococcus, and #Roseburia) are associated with childhood respiratory diseases.
  • [1.15] [#Human milk nutrient fortifiers
    - babies fed HMBFs derived from their own mother’s milk had higher levels of #Veillonella in their stools, which has been shown to help protect #Infants from developing asthma.
  • [1.20] [#Children, #Season Fall
    - in the fall, when respiratory illness and exacerbation events were most frequent, several #Moraxella and #Haemophilus members were enriched both in virus-positive respiratory illnesses and those that progressed to exacerbations.

Common References