Clostridia ⇒ Firmicutes {10000264}

Shared Notes

• [1.2] 
  - Clostridia bacteria gene clusters are able to produce fatty acid amides (FAAs), which are signaling molecules produced by humans.
  - FAAs are known to have diverse physiological effects — ranging from immunoregulation to sensing pain to wound healing.
  - Bacterial enzymes from Clostridia bacteria used diet-derived substrates to produce FAAs that interact with human receptors.
• [1.3] 
  - Genera within the Clostridia and Bacilli classes are necessary and sufficient for P-gp induction in the intestinal epithelium in mouse models.
• [1.4] 
  - Single bout of exercise > upregulated metabolic pathways of skeletal muscle substrate utilization and carbohydrate metabolites in serum > increased fecal ammonia and amino acid metabolites > increased the abundance of Clostridia
• [1.1] 
  - Lukemia >Exposure to antibiotics, in particular piperacillin/tazobactam, meropenem and imipenem/cilastatin (P-I-M), in the 4 weeks before therapy was associated with worse survival and increased neurotoxicity.
  - Lukemia > species within the class Clostridia that were associated with day 100 complete response to Anti-CD19 chimeric antigen receptor (CAR) T cell therapy.