P-glycoprotein {90000195} Record Keys Parent:[ ] Definition:P-glycoprotein Queue:[ ] Details Initialisation date:2021-09-10 Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] - Genera within the #Clostridia and Bacilli classes are necessary and sufficient for P-gp induction in the intestinal epithelium in mouse models. - P-glycoprotein (P-gp) plays a critical role in protection of the intestinal epithelia by mediating efflux of drugs/xenobiotics from the intestinal mucosa into the gut lumen. - P-gp also confers a critical link in communication between intestinal mucosal barrier function and the innate immune system. - Short-chain fatty acid and secondary bile acid production are positively associate with P-gp expression. - in patients suffering from #Ulcerative Colitis (UC), P-gp expression coupled to the reduction of epithelial-derived anti-inflammatory endocannabinoids and luminal content (e.g., microbes or their metabolites) with a reduced capability to induce P-gp expression. [1.2] [#Alzheimer’s disease] - #Butyrate can reduce AD by affecting the p-glycoprotein pathwayReferences Notes[ ]
