Microbiome & Chronic Diseases

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Eubacterium rectale ⇒ Eubacterium {10000528}

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Eubacterium rectale


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References Notes

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Shared Reference Notes

  • [1.31
    - Two of the three E. rectale subspecies consistently harbored an accessory pro-inflammatory flagellum operon associated with lower gut microbiota community diversity, higher host BMI, and higher fasting blood insulin levels
  • - Eubacterium rectale subspecies harboring flagellin-encoding genes were associated with a predominantly #Meat-based diet
  • [1.29
    -The E. rectale bacteria ferment sulfoquinovose via a metabolic pathway that we have only recently deciphered, producing, among other things, a sulfur compound, dihydroxypropane sulfonate or DHPS for short, which in turn serves as an energy source for other intestinal bacteria such as Bilophila wadsworthia. Bilophila wadsworthia ultimately produces hydrogen sulfide from DHPS via a metabolic pathway that was also only recently discovered,
  • [1.32
    - Eubacterium rectale, one of the most prevalent human gut bacteria, can produce #Lauroyl tryptamine. - Auroyl tryptamine is able to bind a human receptor that plays a key role in regulating the immune system and controlling inflammation.
  • [1.1] [#Behcet’s Disease
    - a similar effect was observed by the administration of Eubacterium rectale (a kind of #Butyrate-producing bacteria) in BD mice, which can upregulate NK1.1+ cells and reduce serum IL-17 levels and disease severity scores, sharing the partial mechanism of colchicine, which is used to treat BD patients.
  • [1.33] [#Alzheimer’s disease] [#Bacteroides fragilis] [#Amyloid-beta
    - Presence of #Amyloid deposits was associated with greater abundance of proinflammatory taxa (#Escherichia/#Shigella), which were in turn correlated with proinflammatory cytokines, and with reduced abundance of Eubacterium rectale and B. fragilis, 2 taxa with anti-inflammatory activity
  • [1.3] [#Covid-19
    -anti-inflammatory bacteria, including #Bifidobacteria species and Eubacterium rectale, with lower severity, and pro-inflammatory bacteria such as #Prevotella copri with higher severity.

Common References