Disease
Microbiota ☳
Metabolome
Factor
Eubacterium ⇒ Eubacterium rectale {10000528}
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Definition: Eubacterium rectale
Details
Initialisation date: 2021-04-12
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Domain:
Zone: [ ]
Enzyme: [ ]
Function: [ ]
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[ ] Shared Reference Notes
[1.1 ] - Two of the three E. rectale subspecies consistently harbored an accessory pro-inflammatory flagellum operon associated with lower gut microbiota community diversity, higher host BMI, and higher fasting blood insulin levels
- Eubacterium rectale subspecies harboring flagellin-encoding genes were associated with a predominantly #Meat-based diet
[1.2 ] -The E. rectale bacteria ferment sulfoquinovose via a metabolic pathway that we have only recently deciphered, producing, among other things, a sulfur compound, dihydroxypropane sulfonate or DHPS for short, which in turn serves as an energy source for other intestinal bacteria such as Bilophila wadsworthia. Bilophila wadsworthia ultimately produces hydrogen sulfide from DHPS via a metabolic pathway that was also only recently discovered,
[1.3 ] - Eubacterium rectale , one of the most prevalent human gut bacteria, can produce #Lauroyl tryptamine .
- Auroyl tryptamine is able to bind a human receptor that plays a key role in regulating the immune system and controlling inflammation.
[1.4 ] [#Behcet’s Disease ] - a similar effect was observed by the administration of Eubacterium rectale (a kind of #Butyrate -producing bacteria) in BD mice, which can upregulate NK1.1+ cells and reduce serum IL-17 levels and disease severity scores, sharing the partial mechanism of #Colchicine , which is used to treat BD patients.
[1.5 ] [#Alzheimer’s disease ] [#Bacteroides fragilis ] [#Amyloid-beta ] - Presence of #Amyloid deposits was associated with greater abundance of proinflammatory taxa (#Escherichia /#Shigella ), which were in turn correlated with proinflammatory cytokines, and with reduced abundance of Eubacterium rectale and B. fragilis, 2 taxa with anti-inflammatory activity
[1.6 ] [#Covid-19 ] -anti-inflammatory bacteria, including #Bifidobacteria species and Eubacterium rectale , with lower severity, and pro-inflammatory bacteria such as #Prevotella copri with higher severity.
[1.7 ] [#Alzheimer’s disease ] - AD > A positive correlation between the pro-inflammatory cytokines and Escherichia/Shigella (pro-inflammatory taxon) and a negative correlation with Eubacterium rectale (anti-inflammatory taxon).
- a decrease in #Firmicutes and #Bifidobacterium and increased levels of #Proteobacteria , #Actinobacteria
- a disputed frequency of #Bacteroidetes in various studies..
[1.8 ] [#Bacteroides massiliensis ] - #Prostate cancer > a higher relative abundance of Bacteriodes massiliensis as well as decreased relative abundances of #Faecalibacterium prausnitzii and Eubacterium rectale in the stool from men with PCa compared to the controls.
[1.9 ] [#Chronic fatigue syndrome ] - #Faecalibacterium prausnitzii and Eubacterium rectale , which are both recognized as abundant, health-promoting #Butyrate producers in the human gut, were reduced in ME/CFS.
- deficient microbial capacity for #Butyrate synthesis.
- The abundance of #Faecalibacterium prausnitzii was inversely associated with fatigue severity.
[#Actinomyces massiliensis ] - #Athletes from 16 different sports > dominated by a single or a combination of five species, namely Eubacterium rectale , Polynucleobacter necessarius, #Faecalibacterium prausnitzii , #Bacteroides vulgatus , and #Gordonibacter massiliensis.
- Species such as #Bifidobacterium animalis , #Lactobacillus acidophilus , #Prevotella intermedia , and F. prausnitzii were associated with #Athletes participating in high dynamic component sports.
[1.11 ] [#Diabetes Type 1 ] - Studies have reported an increased quantity of #Villanella , #Clostridium , and #Bacteroides and a decreased quantity of #Lactobacillus , Eubacterium rectale , #Blautia coccoides , and #Bifidobacterium in #Children with type 1 diabetes.
[1.12 ] [#Resistant starch ] - RS could also be degraded by #Ruminococcus bromii , and #Bifidobacterium adolescentis , and also to a lesser extent by Eubacterium rectale and #Bacteroides thetaiotaomicron .
- in the mixed bacterial and fecal incubations, RS degradation is impossible in the absence of R. bromii
Intervention in Disease [ ]
Author: MetaBiom
Identifier: 10000528
URL: https://www.metabiom.org/microbiota/473/eubacterium-rectale
Keywords: Microbiome, Dysbiosis, Microbiota, Organism, Bacteria
Common References
[1.1 ] Diet and gut microbiome interactions of relevance for symptoms in irritable bowel syndrome [2021] [Review] [Microbiome] [Journal] [80001736 ]
[1.2 ] Sulfoquinovose is a select nutrient of prominent bacteria and a source of hydrogen sulfide in the human gut [2021] [Research] [The ISME Journal] [Journal] [80001764 ]
[1.3 ] Gut-inhabiting Clostridia build human GPCR ligands by conjugating neurotransmitters with diet- and human-derived fatty acids [2021] [Research] [Nature Microbiology] [Journal] [80001868 ]
[1.4 ] Findings on the Relationship Between Intestinal Microbiome and Vasculitis [2022] [Frontiers in Cellular and Infection Microbiology] [Journal] [80002464 ]
[1.5 ] Role of the gut microbiota in the development of various neurological diseases [2022] [Review] [NeurologĂa (English Edition)] [Journal] [80002479 ]
[1.6 ] COVID-19 severity is associated with population-level gut microbiome variations [2022] [Review] [Frontiers in Cellular and Infection Microbiology] [Journal] [80002553 ]
[1.7 ] The gut microbiome in Alzheimer’s disease: what we know and what remains to be explored [2023] [Review] [Molecular Neurodegeneration] [Journal] [80002733 ]
[1.8 ] Dysbiotic microbes and how to find them: a review of microbiome profiling in prostate cancer [2022] [Review] [Journal of Experimental & Clinical Cancer Research] [Journal] [80002745 ]
[1.9 ] Deficient butyrate-producing capacity in the gut microbiome is associated with bacterial network disturbances and fatigue symptoms in ME/CFS [2023] [Study] [Cell Host & Microbe] [Journal] [80002751 ]
[1.10 ] Intertwined Relationship of Mitochondrial Metabolism, Gut Microbiome and Exercise Potential [2022] [Study] [International journal of molecular sciences] [Journal] [80003004 ]
[1.11 ] Gut Microbiome–Brain Alliance: A Landscape View into Mental and Gastrointestinal Health and Disorders [2023] [Review] [ACS Chemical Neuroscience] [Journal] [80003039 ]
[1.12 ] Prebiotics: Definition, Types, Sources, Mechanisms, and Clinical Applications [2019] [Foods] [Journal] [80003325 ]
[1.13 ] Intestinal floras of populations that have a high risk of colon cancer [1995] [Applied and Environmental Microbiology] [Journal] [80001116 ]
[1.14 ] Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly. [2017] [Neurobiology of Aging] [Journal] [80000280 ]
[1.15 ] Probiotics improve renal function, glucose, lipids, inflammation and oxidative stress in diabetic kidney disease: a systematic review and meta-analysis [2022] [Renal Failure] [Journal] [80002470 ]
[1.16 ] Altered gut microbiota and short chain fatty acids in Chinese children with autism spectrum disorder [2019] [Scientific Reports] [Journal] [80000947 ]
[1.17 ] Altered gut microbiota and microbial biomarkers associated with chronic kidney disease [2018] [MicrobiologyOpen] [Journal] [80000867 ]
[1.18 ] Alterations of the human gut microbiome in liver cirrhosis [2014] [Nature] [Journal] [80000668 ]
[1.19 ] Real-time polymerase chain reaction quantification of specific butyrate-producing bacteria, Desulfovibrio and Enterococcus faecalis in the feces of patients with colorectal cancer. [2008] [Journal of Gastroenterology and Hepatology] [Journal] [80000301 ]
[1.20 ] Dysbiosis signatures of gut microbiota in coronary artery disease [2018] [Physiological genomics] [Journal] [80000879 ]
[1.21 ] Alterations in gut microbiota of patients with COVID-19 during time of hospitalization [2020] [Gastroenterology] [Journal] [80001420 ]
[1.22 ] Dysbiosis of fecal microbiota in Crohn’s Disease patients as revealed by a custom phylogenetic microarray [2010] [Inflammatory Bowel Diseases] [Journal] [80000285 ]
[1.23 ] Spatial organization and composition of the mucosal flora in patients with inflammatory bowel disease [2005] [Journal of Clinical Microbiology] [Journal] [80000610 ]
[1.24 ] Metagenomic evidence for taxonomic dysbiosis and functional imbalance in the gastrointestinal tracts of children with cystic fibrosis [2016] [Scientific Reports] [Journal] [80000395 ]
[1.25 ] Toward defining the autoimmune microbiome for type 1 diabetes [2011] [The ISME Journal] [Journal] [80000310 ]
[1.26 ] A metagenome-wide association study of gut microbiota in type 2 diabetes. [2012] [Nature] [Journal] [80000240 ]
[1.27 ] Aberrant gut microbiota alters host metabolome and impacts renal failure in humans and rodents [2020] [Gut] [Journal] [80001376 ]
[1.28 ] Intestinal microbiota is altered in patients with gastric cancer from Shanxi Province, China [2019] [Digestive Diseases and Sciences] [Journal] [80001028 ]
[1.29 ] Altered gut microbiota profile in patients with generalized anxiety disorder [2018] [Journal of Psychiatric Research] [Journal] [80001066 ]
[1.30 ] Dysbiosis and compositional alterations with aging in the gut microbiota of patients with heart failure. [2017] [PLOS ONE] [Journal] [80000396 ]
[1.31 ] Imbalance of gut microbiome and intestinal epithelial barrier dysfunction in patients with high blood pressure [2018] [Clinical Science (London)] [Journal] [80000785 ]
[1.32 ] Fecal microbiota profiles in treatment-naïve pediatric inflammatory bowel disease - associations with disease phenotype, treatment, and outcome [2019] [Clinical and Experimental Gastroenterology] [Journal] [80000963 ]
[1.33 ] Dysbiosis in the gut microbiota of patients with multiple sclerosis, with a striking depletion of species belonging to Clostridia XIVa and IV clusters. [2015] [PLOS ONE] [Journal] [80000233 ]
[1.34 ] The gut microbiome signatures discriminate healthy from pulmonary tuberculosis patients [2019] [Frontiers in Cellular and Infection Microbiology] [Journal] [80001136 ]
[1.35 ] Fecal microbiota in early rheumatoid arthritis [2008] [The Journal of Rheumatology] [Journal] [80001229 ]
[1.36 ] Gut microbiota dysbiosis in male patients with chronic traumatic complete spinal cord injury [2018] [Journal of Translational Medicine] [Journal] [80000938 ]
[1.37 ] Gut microbiota differs between children with inflammatory bowel disease and healthy siblings in taxonomic and functional composition: a metagenomic analysis [2017] [American journal of physiology. Gastrointestinal and liver physiology] [Journal] [80000660 ]
[1.38 ] Rethinking healthy eating in light of the gut microbiome [2022] [Review] [Cell Host & Microbe] [Journal] [80002441 ]
[1.39 ] Next Generation Microbiome Research: Identification of Keystone Species in the Metabolic Regulation of Host-Gut Microbiota Interplay [2021] [Review] [Frontiers in Cell and Developmental Biology] [Journal] [80002163 ]