Disease ⇒ Colon polyps {40000437} Record Keys Type:Disease Parent:[ ] Definition:Colon polyps Details Initialisation date:2022-02-07 Other Terms:[ ] Meta Information MedDra ID:10010003 MedDra Level:llt ICD:[ ] Category:[ ] Zone: Gut Mechanism:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Bacteroides fragilis] [#Lipopolysaccharide] - BF is enriched in patients with polyps > inflammatory cytokines in the mucosa adjacent to polyps. - BF from polyps is enriched for LPS biosynthesis genes, activates TLR4, and induces IL-12 > induce a pro-inflammatory response. - Presence of LPS genes and elevated expression of LPS are found in polyp tissues. [1.2] [#Fusobacterium mortiferum] - The anaerobic F. mortiferum commonly colonizes the gastrointestinal tract (albeit in low abundance) of the Chinese, but not Western, population, and its proliferation has been recently noted in patients with colorectal polyps [1.3] [#Colon adenomas] [#Fusobacterium nucleatum] - F. nucleatum modifies colonic Th17 cell frequency and IL-17 expression recombinant free fatty acid receptor 2 (FFAR2)-dependent. - it positively correlated with the expression of Wnt-β-catenin (activated by FadA─E-cadherin) and REG Iα signaling, both of which effectively promotes the proliferation of sessile serrated adenoma/polyp - #Mogibacterium is significantly more abundant in patients with adenomatous polypsReferences Notes[ ]
