Disease ⇒ Colon polyps {40000437}
| Type: | Disease |
|---|---|
| Definition: | Colon polyps |
| Parent: | [ ] |
| Initialisation date: | 2022-02-07 |
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| Other Terms: | [ ] |
| MedDra ID: | 10010003 |
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| MedDra Level: | llt |
| ICD: | [ ] |
| Category: | [ ] |
| Zone: | Gut |
| Mechanism: | [ ] |
Notes:
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References Notes
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Shared Reference Notes
- [1.1] [#Bacteroides fragilis] [#Lipopolysaccharide]
- BF is enriched in patients with polyps > inflammatory cytokines in the mucosa adjacent to polyps. - BF from polyps is enriched for LPS biosynthesis genes, activates TLR4, and induces IL-12 > induce a pro-inflammatory response. - Presence of LPS genes and elevated expression of LPS are found in polyp tissues. - [1.3] [#Fusobacterium mortiferum]
- The anaerobic F. mortiferum commonly colonizes the gastrointestinal tract (albeit in low abundance) of the Chinese, but not Western, population, and its proliferation has been recently noted in patients with colorectal polyps