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Microbiome & Chronic Diseases

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Salmonella typhimurium ⇒ Salmonella {10000155}

Record Keys


Organism:
Salmonella typhimurium
Parent:

Details


Initialisation date:
2020-09-06

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Meta Information


Rank:
 Species
Domain:
 Bacteria
Zone:[  ]
Enzyme:[  ]
Function:[  ]

Notes:


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References Notes


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Shared Reference Notes


  • [1.1
    - S. typhimurium, an intracellular pathogen, is chemoattracted to, and retained in, tumors due to the presence of metabolites produced by quiescent #Cancer cells within the TME (Tumor Micro envirounment). - Once in the tumor, S. typhimurium continues to proliferate and directly kills #Cancer cells by triggering of apoptosis, necrosis, and cell rupture. - S. typhimurium flagellin has been found to mount the antitumor response of CD8+ T and Natural Killer (NK) cells and to reduce the frequency of regulatory T cells (Tregs)
  • [1.2] [#Inflamatory bowel disease
    - adherent-invasive #Escherichia coli (AIEC), and Salmonella enterica serovar Typhimurium > induce inflammation (through elevated T helper (TH) 1 and TH17 immune responses) in IBD animal model > fibrosis development. - in patients with #Crohn’s disease, AIEC strains > ileal mucosa > trigger the initiation or perpetuation of the inflammatory disease.
  • [1.3] [#Short Chain Fatty Acid
    - SCFAs have been confirmed to display antibacterial activity by disturbing the intracellular acid-alkaline balance or acylating certain virulence factors of Salmonella typhimurium

Common References