Disease ⇒ Endometriosis {40000403}

Shared Reference Notes

• [1.1] 
  - enhanced IL-1β signaling, which occurs in response to inflammasome activation, promotes endometriotic angiogenesis. - peritoneal fluid of women with endometriosis has elevated IL-1β, which promotes the release of cytokines, such as Interleukin 8 (IL-8), and growth factors that contribute to neovascularization and monocyte chemotaxis in endometriotic explants.
• - Increased abundance of #Acidovorax, #Devosia, #Methylobacterium, #Phascolarctobacterium, and #Streptococcus in the peritoneal fluid of endometriosis patients
• [#Antibiotic Therapy] - treatment with either broad-spectrum antibiotics or metronidazole after lesion initiation reduced lesion growth in a surgical model of endometriosis
• - n-#Butyrate protects against endometriosis disease progression in mouse model of this disease
• - women with endometriosis had elevated #Gardnerella, #Streptococcus, #Escherichia, #Shigella, and #Ureoplasma in their cervix and elevated #Shigella/#Escherichia in their stool
• - microbiota-depleted (MD) mice showed reduced endometriotic lesion growth and, the transplantation of gut microbiota by oral gavage of feces from mice with endometriosis rescued the endometriotic lesion growth. - #Quinic acid promoted the survival of endometriotic epithelial cells in vitro and lesion growth in vivo but not the establishment of lesions.
• [1.2] [#Inflamatory bowel disease] [#Akkermansia muciniphila] [#Antibiotic Therapy] 
  - Conditions like inflammatory bowel disease (IBD), #Salmonella typhimurium infection or post-antibiotic reconstitution may not benefit from #Akkermansia supplementation. - using #Akkermansia in patients with endocrine and gynecological disorders—such as #Polycystic ovary syndrome (PCOS) or endometriosis—that have a higher risk of developing IBD, should be critically evaluated. - the gut microbiota of patients suffering from #Parkinson’s Disease or #Multiple Sclerosis exhibits a characteristic signature of #Akkermansia municiphila abundance.
• [1.3] [#Antibiotic Therapy] 
  - Immunohistochemical and biochemical analyses revealed that activated transforming growth factor–β (TGF-β) signaling resulting from #Fusobacterium infection of endometrial cells led to the transition from quiescent fibroblasts to transgelin (TAGLN)–positive myofibroblasts, which gained the ability to proliferate, adhere, and migrate in vitro. - #Fusobacterium inoculation in a syngeneic mouse model of endometriosis resulted in a marked increase in TAGLN-positive myofibroblasts and increased number and weight of endometriotic lesions. - antibiotic treatment largely prevented establishment of endometriosis and reduced the number and weight of established endometriotic lesions in the mouse model.

References Notes