Disease ⇒ Endometriosis {40000403} Record Keys Type:Disease Parent:[ ] Definition:Endometriosis Details Initialisation date:[ ] Other Terms:[ ] Meta Information MedDra ID:10014778 MedDra Level:pt ICD:[ ] Category:[ ] Zone:[ ] Mechanism:[ ] Notes: [ ]Shared Reference Notes [1.1] - enhanced IL-1β signaling, which occurs in response to inflammasome activation, promotes endometriotic angiogenesis. - peritoneal fluid of women with endometriosis has elevated IL-1β, which promotes the release of cytokines, such as Interleukin 8 (IL-8), and growth factors that contribute to neovascularization and monocyte chemotaxis in endometriotic explants. - Increased abundance of #Acidovorax, #Devosia, #Methylobacterium, #Phascolarctobacterium, and #Streptococcus in the peritoneal fluid of endometriosis patients [#Antibiotic Therapy] - treatment with either broad-spectrum antibiotics or metronidazole after lesion initiation reduced lesion growth in a surgical model of endometriosis - n-#Butyrate protects against endometriosis disease progression in mouse model of this disease - women with endometriosis had elevated #Gardnerella, #Streptococcus, #Escherichia, #Shigella, and #Ureoplasma in their cervix and elevated #Shigella/#Escherichia in their stool - microbiota-depleted (MD) mice showed reduced endometriotic lesion growth and, the transplantation of gut microbiota by oral gavage of feces from mice with endometriosis rescued the endometriotic lesion growth. - #Quinic acid promoted the survival of endometriotic epithelial cells in vitro and lesion growth in vivo but not the establishment of lesions. [1.2] [#Inflamatory bowel disease] [#Akkermansia muciniphila] [#Antibiotic Therapy] - Conditions like inflammatory bowel disease (IBD), #Salmonella typhimurium infection or post-antibiotic reconstitution may not benefit from #Akkermansia supplementation. - using #Akkermansia in patients with endocrine and gynecological disorders—such as #Polycystic ovary syndrome (PCOS) or endometriosis—that have a higher risk of developing IBD, should be critically evaluated. - the gut microbiota of patients suffering from #Parkinson’s Disease or #Multiple Sclerosis exhibits a characteristic signature of #Akkermansia municiphila abundance. [1.3] [#Estrogen] - higher levels of taxa that encode for β-glucuronidase, which are mainly #Bifidobacterium and #Escherichia, in endometriosis women compared with control women. [#Estrogen] - β-glucuronidase promoted endometriosis development directly or indirectly by causing macrophage dysfunction.References Notes[ ]
