Veillonellaceae ⇒ Megasphaera {10000959}

Shared Reference Notes

• [1.1] 
  - Megasphaera is consistently associated with advanced MAFLD and #Steatohepatitis
• [1.2] [#Inflamatory bowel disease] [#Short Chain Fatty Acid] 
  The first signs of aggravation of IBD are : - a loss of the main anti-inflammatory Short-Chain Fatty Acids (SCFAs) #Roseburia, #Eubacterium, #Subdoligranumum, #Ruminococcus - an increase in pro-inflammatory pathogens #Proteus, #Finegoldia - an increase of other minor SCFA producers such as #Ezakiella, #Anaerococcus, Megasphaera, #Anaeroglobus, #Fenollaria. - Further aggravation of clinical signs is significantly linked to the subsequent loss of these minor SCFAs species and to an increase in other proinflammatory Proteobacteria such as Klebsiella, Pseudomonas, Salmonella, Acinetobacter, Hafnia and proinflammatory Firmicutes such as Staphylococcus, Enterococcus, Streptococcus.
• [1.3] [#Bipolar disorder, #Major depressive disorder, #Schizophrenia] 
  - MDD and SZ shared higher levels of #Escherichia/#Shigella and #Veillonella whereas increased Megasphaera and lower #Roseburia are common for BD and SZ.
• [1.4] [#Non-alcoholic fatty liver disease] 
  - #Dorea, #Lactobacillus and Megasphaera are enriched in MAFLD group.
• [1.5] [#Parkinson’s Disease] 
  - abundance of Megasphaera and #Akkermansia, and reduced #Roseburia in PD patients

References Notes