Microbiome & Chronic Diseases

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Disease ⇒ Chronic periodontitis {40000290}

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Chronic periodontitis


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Shared Reference Notes

  • [1.1] [#Periodontal disease
    - #Aggregatibacter actinomycetemcomitans (Aa) is a Gram-negative coccobacillus recognized as a pathogen in periodontitis and infective endocarditis. By producing a toxin (#Leukotoxin A, LtxA) that triggers global hypercitrullination in neutrophils, Aa has been recently linked to #Rheumatoid Arthritis. - Aa has been proposed as a link between periodontitis and autoimmunity in #Rheumatoid Arthritis (RA) due to its ability to induce citrullinated autoantigens targeted by anti-citrullinated protein antibodies (ACPAs).
  • [1.2] [#Lactobacillus lactis] [#Nisin probiotic
    - #Nisin and a #Nisin-producing Lactococcus lactis probiotic significantly decreased the levels of several periodontal pathogens, alveolar bone loss, and the oral and systemic inflammatory host response. - Surprisingly, #Nisin and/or the #Nisin-producing L. lactis probiotic enhanced the population of fibroblasts and osteoblasts despite the polymicrobial infection.
  • [1.3] [#Diabetes Type 2
    - Elevated IL-6 and CRP levels associated with Periodontitis, as significant risk factors for insulin resistance and diabetes mellitus
  • [1.4] [#Periodontal abscess
    - periodontopathogens can be disseminated through the blood flow to other body parts where they may enhance inflammatory processes that can lead to the development or exacerbation of #Atherosclerosis.
  • [1.5] [#Periodontal disease] [#Fusobacterium nucleatum
    - Chronic oral infection establishes ectopic oral F. nucleatum colonization in the intestine and significantly induces systemic humoral IgG and IgM antibody responses
  • [1.6] [#Periodontal disease
    - Dental treatment significantly improved the oral health condition of each group; several months after treatment, oral health did not deteriorate. - even after remission, the salivary microbiome of the two groups (oral disease and healthy) differed significantly. - Oral microbiome dysbiosis persisted even after dental treatment-induced disease remission with a sustained increased risk of disease when compared with healthy participants.

References Notes

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