Leukotoxin A [LtxA] {60000113} Record Keys Parent:[ ] Definition:Leukotoxin A Queue:LtxA Details Initialisation date:2020-10-23 Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Chronic periodontitis, #Periodontal disease] - #Aggregatibacter actinomycetemcomitans (Aa) is a Gram-negative coccobacillus recognized as a pathogen in periodontitis and infective endocarditis. By producing a toxin (leukotoxin A, LtxA) that triggers global hypercitrullination in neutrophils, Aa has been recently linked to #Rheumatoid Arthritis. - Aa has been proposed as a link between periodontitis and autoimmunity in #Rheumatoid Arthritis (RA) due to its ability to induce citrullinated autoantigens targeted by anti-citrullinated protein antibodies (ACPAs).References Notes[ ]
