Disease ⇒ Dry eye syndrom {40000166} Record Keys Type:Disease Parent:[ ] Definition:Dry eye syndrom Details Initialisation date:2019-06-23 Other Terms:Keratoconjunctivitis sicca , DES LinksWickipediaMerck Manual Meta Information MedDra ID:10013774 MedDra Level:pt ICD:[ ] Category:Ophtalmology Zone:[ ] Mechanism:[ ] Notes: [ ]Shared Reference Notes [1.1] - Proteobacteria, Firmicutes/Bacteroidetes ratio, and genus Lactobacillus, Alistipes, Prevotella, Paraprevotella, and Helicobacter to be significantly associated with dry eye severity. [1.2] - Microbial communities in dry eye disease are distinct and remain distinct even with daily saline eye wash. - In dry eye disease, increased microbial diversity is a hallmark of disease. [1.3] [#Short Chain Fatty Acid] - Dry eye syndrom > Reduced SCFA has been found to alter the circadian rhythm, which in turn reduces lacrimal gland secretions. [1.4] - family #Propionibacteriaceae and the species #Corynebacterium tuberculostearicum were more abundant in DED patients compared to controls. - Both #Corynebacterium tuberculostearicum and bacteria of the family #Propionibacteriaceae are involved in inflammatory processes through the upregulation of pro-inflammatory cytokines that may be associated with DED. - the conjunctiva of DED patients was decreased in genes of L-lysine biosynthesis, tetrapyrrole biosynthesis, 5-aminoimidazole ribonucleotide biosynthesis, and the super pathway of L-#Threonine biosynthesis. [1.5] - #Streptococcus and #Pedobacter bacteria species were the most prevalent microbes in healthy eyes while more #Acinetobacter species were present in the eye microbiomes of people with dry eye.References Notes [1.8]
