Disease ⇒ Mild Cognitive Impairment {40000532}

Shared Reference Notes

• [1.1] [#Alzheimer’s disease, #Cognitive impairment] [#Mediterranean Ketogen Diet] 
  - Participants with MCI on the MMKD had lower levels of #GABA-producing microbes #Alistipes sp. CAG:514 and #GABA, and higher levels of #GABA-regulating microbes #Akkermansia muciniphila.
• - the ratio of #Ruminococcus sp. CAG:330 to #Bacteroides fragilis CAG: 47 is consistently elevated in MCI
• - the ratio of two particular plant-associated metabolites to #Betaine, an osmoregulatory compound downstream of #Choline, was significantly higher in normal cognition than mild cognitive impairment
• [#Bile Acids] [#Curcumin, #Mediterranean Ketogen Diet] - MCI individuals with #Curcumin in their diet had lower levels of #Bile Salt hydrolase-containing microbes and an altered bile acid pool, suggesting reduced gut motility.
• [1.2] [#Alzheimer’s disease] [#Aging, #Mediterranean Ketogen Diet] 
  - feeding modified Mediterranean-ketogenic diet (MMKD) increased production of #Butyrate, which was associated with reduced AD markers in the cerebrospinal fluid of older adults with MCI
• [#Cognitive impairment] [#Bacteriophage] - higher abundance of #Lactobacillus phages (family #Siphoviridae of the order #Caudovirales positively associated with better cognitive function; and transplantation of these phages from humans to mice and Drosophila showed increased memory scores and upregulation of memory-involved brain genes.
• [#Aging] - overall abundance of viruses increased in the gut of older adults with MCI compared with controls. - abundance of Podovirideae, Inovirideae, Myovirideae, and Siphovirideae, which belong to #Bacteriophage types of viral families
• - the abundance of #Butyrate producing bacteria such as #Lachnospiraceae family, #Subdoligranulum sp., #Roseburia intestinalis, and #Roseburia hominis were reduced in the gut of MCI participants compared to cognitively healthy controls.
• [#Aging, #Bacteriophage] - older adults with MCI had higher abundance of Lactococcus phage ul36 which specifically regulates the #Probiotic bacteria like #Lactococcus lactis (a common yogurt culture)
• [1.3] [#Cognitive impairment] [#Olive] 
  - participants who consumed a #Mediterranean diet supplemented with either EVOO or #Nuts had improved cognitive function compared with those that consumed a low-fat diet.
• [1.4] 
  - #Prevotella ruminicola, #Bacteroides thetaiotaomicron, and #Bacteroides xylanisolvens as taxa correlated with MCI.
• - #Prevotella is significantly more prevalent in MCI subjects compared to cognitively intact subjects. - A decrease in the relative abundance of the genus #Prevotella and Dehalobacterium in response to LGG supplementation in the MCI group was correlated with an improved cognitive score.
• [1.5] [#Alzheimer’s disease] 
  - decreased #Formate among individuals with AD and MCI suggests alterations in #Tryptophan degradation in AD.

References Notes