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Microbiome & Chronic Diseases

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Disease ⇒ Biliary atresia {40000456}

Record Keys


Type:
Disease
Definition:
Biliary atresia
Parent:[  ]

Details


Initialisation date:[  ]
Other Terms:
BA

Meta Information


MedDra ID:
10004653
MedDra Level:
llt
ICD:[  ]
Category:[  ]
Zone:[  ]
Mechanism:[  ]

Notes:


[  ]

Shared Notes


  • [1.2
    - Butyrate administration to mothers > renders newborn mice resistant to inflammation and injury of bile ducts > improves survival.
    - Bacteroidetes and Clostridia and increases glutamate/glutamine and hypoxanthine in stool metabolites of newborn mice > prevention of hepatic immune cell activation and survival.
    - In human neonates with biliary atresia, the fecal microbiome signature of these bacteria is under-represented, with suppression of glutamate/glutamine and increased hypoxanthine pathways.
    - The direct administration of butyrate or glutamine to newborn mice attenuates the disease phenotype, but only glutamine renders bile duct epithelial cells resistant to cytotoxicity by natural killer cells.

Common References