Disease ⇒ Biliary atresia {40000456}

References Notes

Shared Reference Notes

• [1.2] 
  - #Butyrate administration to mothers > renders newborn mice resistant to inflammation and injury of bile ducts > improves survival. - Bacteroidetes and Clostridia and increases glutamate/#Glutamine and hypoxanthine in stool metabolites of newborn mice > prevention of hepatic immune cell activation and survival. - In human neonates with biliary atresia, the fecal microbiome signature of these bacteria is under-represented, with suppression of glutamate/#Glutamine and increased hypoxanthine pathways. - The direct administration of #Butyrate or #Glutamine to newborn mice attenuates the disease phenotype, but only #Glutamine renders bile duct epithelial cells resistant to cytotoxicity by natural killer cells.