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Disease ⇒ Biliary atresia {40000456}

Record Keys


Type:
Disease
Definition:
Biliary atresia
Parent:[  ]

Details


Initialisation date:[  ]
Other Terms:
BA

Meta Information


MedDra ID:
10004653
MedDra Level:
llt
ICD:[  ]
Category:[  ]
Zone:[  ]
Mechanism:[  ]

Notes:


[  ]

References Notes


[  ]

Shared Reference Notes


  • [1.2
    - #Butyrate administration to mothers > renders newborn mice resistant to inflammation and injury of bile ducts > improves survival. - Bacteroidetes and Clostridia and increases glutamate/#Glutamine and hypoxanthine in stool metabolites of newborn mice > prevention of hepatic immune cell activation and survival. - In human neonates with biliary atresia, the fecal microbiome signature of these bacteria is under-represented, with suppression of glutamate/#Glutamine and increased hypoxanthine pathways. - The direct administration of #Butyrate or #Glutamine to newborn mice attenuates the disease phenotype, but only #Glutamine renders bile duct epithelial cells resistant to cytotoxicity by natural killer cells.

Common References