Disease ⇒ Biliary atresia {40000456}
Type: | Disease |
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Definition: | Biliary atresia |
Parent: | [ ] |
Initialisation date: | [ ] |
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Other Terms: | BA |
MedDra ID: | 10004653 |
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MedDra Level: | llt |
ICD: | [ ] |
Category: | [ ] |
Zone: | [ ] |
Mechanism: | [ ] |
Notes:
[ ]
Shared Notes
- [1.2]
- Butyrate administration to mothers > renders newborn mice resistant to inflammation and injury of bile ducts > improves survival.
- Bacteroidetes and Clostridia and increases glutamate/glutamine and hypoxanthine in stool metabolites of newborn mice > prevention of hepatic immune cell activation and survival.
- In human neonates with biliary atresia, the fecal microbiome signature of these bacteria is under-represented, with suppression of glutamate/glutamine and increased hypoxanthine pathways.
- The direct administration of butyrate or glutamine to newborn mice attenuates the disease phenotype, but only glutamine renders bile duct epithelial cells resistant to cytotoxicity by natural killer cells.