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Disease ⇒ Alcoholic Hepatitis {40000181}

Record Keys


Type:
Disease
Definition:
Alcoholic Hepatitis
Parent:[  ]

Details


Initialisation date:
2020-09-25
Other Terms:[  ]

Meta Information


MedDra ID:
10019717
MedDra Level:
pt
ICD:[  ]
Category:
Gastroenterology, DietNutrition, Metabolomics
Zone:[  ]
Mechanism:[  ]

Notes:


- Alcoholic hepatitis patients with more severe disease had significantly decreased relative abundances of Akkermansia while the relative abundance of Veillonella was increased. We observed a reduction in the Bacteroides abundance (Padjust = 0.048) and Shannon diversity (Padjust = 0.018) in antibiotic-treated patients and patients receiving steroids had an increase in Veillonella abundance (Padjust = 0.005), which was both independent of potentially confounding factors. (1)

References Notes


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Shared Reference Notes


  • [1.5
    - CIG could inhibit the activities of AST, ALT and MDA, promote the activities of SOD, CAT and GSH, and reduce oxidative damage to the liver. CIG could significantly alter intestinal microbial diversity, reduce the presence of serum LPS and levels of TNF-α, IL-1β and IL-6 in the liver. In addition,
    - CIG supplementation reduced the imbalance of intestinal microbiota caused by alcohol and improved intestinal barrier function.
  • [1.6
    - Enterococcus produces cytolysin in subjects with Severe alcohol-associated hepatitis.
    - The use of phages to target pathogenic bacteria in the gut improves liver inflammation in animal models.
    - The transfer of alcohol-associated hepatitis via fecal transplant in animal models confirms a major role of Gut Microbiata in the initiation and progression of severe alcoholic liver disease.