Disease ⇒ Primary sclerosing cholangitis {40000179}

Record Keys
Type:	Disease
Definition:	Primary sclerosing cholangitis
Parent:	[ ]

Details
Initialisation date:	2020-09-20
Other Terms:	PSC

Links
Wickipedia Merck Manual

Meta Information
MedDra ID:	10008609
MedDra Level:	pt
ICD:	[ ]
Category:	Rheumatology
Zone:	[ ]
Mechanism:	[ ]

Notes:

- The salivary microbial signature of PSC was significantly altered as compared to healthy controls, independent of concomitant IBD, and was comprised of 19 significantly altered species, of which, eight species were consistently overrepresented in both fecal and saliva of patients with PSC, including Veillonella, Scardovia and Streptococcus. (1)

References Notes

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Shared Reference Notes

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↥ Microbiota

‐ Bacteroides ‎Stool ‎Human [1.1]
‐ Clostridium ‎Stool ‎Human [1.2]
‐ Enterococcus faecalis ‎Bile ‎Human [1.3]
‐ Enterococcus faecium ‎Stool ‎Human [1.4]
‐ Enterococcus sp. NBRC 107345 ‎Stool ‎Human [1.4]
‐ Enterococcus ‎Stool ‎Human [1.4]
‐ Enterococcus ‎Tissue biopsie ‎Human [1.3]
‐ Escherichia coli ‎Tissue biopsie ‎Human [1.3]
‐ Exophiala ‎Stool ‎Human [1.5]
‐ Fusobacterium ‎Stool ‎Human [1.6]
‐ Haemophilus ‎Stool ‎Human [1.2]
‐ Lactobacillus ‎Stool ‎Human [1.6]
‐ Morganella ‎Stool ‎Human [1.6]
‐ Neisseria ‎Tissue biopsie ‎Human [1.3]
‐ Oribacterium ‎Saliva ‎Human [1.7]
‐ Parabacteroides ‎Stool ‎Human [1.1]
‐ Rothia mucilaginosa ‎Stool ‎Human [1.2]
‐ Scardovia ‎Oral & Gut Lumen ‎Human
‐ Staphylococcus ‎Tissue biopsie ‎Human [1.3]
‐ Streptococcus alactolyticus ‎Stool ‎Human [1.2]
‐ Streptococcus equi ‎Stool ‎Human [1.2]
‐ Streptococcus infantis ‎Stool ‎Human [1.2]
‐ Streptococcus parasanguinis ‎Stool ‎Human [1.4]
‐ Streptococcus ‎Oral & Gut Lumen ‎Human
‐ Streptococcus ‎Stool ‎Human [1.6]
‐ Veillonella dispar ‎Bile ‎Human [1.3]
‐ Veillonella dispar ‎Stool ‎Human [1.2]
‐ Veillonella dispar ‎Tissue biopsie ‎Human [1.3]
‐ Veillonella parvula ‎Stool ‎Human [1.2]
‐ Veillonella ‎Oral & Gut Lumen ‎Human
‐ Veillonella ‎Stool ‎Human [1.4]

↧ Microbiota

‐ Adlercreutzia equolifaciens ‎Stool ‎Human [1.2]
‐ Anaerostipes ‎Stool ‎Human [1.6]
‐ Blautia obeum ‎Stool ‎Human [1.4]
‐ Blautia ‎Stool ‎Human [1.5]
‐ Christensenellaceae ‎Stool ‎Human [1.8]
‐ Coprococcus catus ‎Stool ‎Human [1.2]
‐ Coprococcus ‎Stool ‎Human [1.8]
‐ Desulfovibrio ‎Stool ‎Human [1.8]
‐ Faecalibacterium prausnitzii ‎Stool ‎Human [1.2]
‐ Faecalibacterium ‎Stool ‎Human [1.5]
‐ Haemophilus ‎Saliva ‎Human [1.7]
‐ Lachnoclostridium ‎Stool ‎Human [1.5]
‐ Lachnospiraceae ‎Stool ‎Human [1.8]
‐ Parabacteroides distasonis ‎Stool ‎Human [1.4]
‐ Parabacteroides ‎Stool ‎Human [1.4]
‐ Phascolarctobacterium ‎Stool ‎Human [1.8]
‐ Prevotella copri ‎Stool ‎Human [1.2]
‐ Rothia ‎Saliva ‎Human [1.7]
‐ Ruminiclostridium ‎Stool ‎Human [1.5]
‐ Ruminococcus gnavus ‎Stool ‎Human [1.2]
‐ Ruminococcus ‎Stool ‎Human [1.5]
‐ Saccharomyces cerevisiae ‎Stool ‎Human [1.5]
‐ Succinivibrio ‎Stool ‎Human [1.8]
‐ uncultured Clostridiales II ‎Mucosal biopsies of colon ‎Human [1.9]

↥ Metabolome

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↧ Metabolome

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Related Factor

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Subclass

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References

(1) [Abstract] [2020] Alterations of the salivary and fecal microbiome in patients with primary sclerosing cholangitis

Common References

[1.1] Consistent alterations in faecal microbiomes of patients with primary sclerosing cholangitis independent of associated colitis [2019] [Alimentary Pharmacology & Therapeutics] [Journal] [80001214]
[1.2] Distinct gut microbiota profiles in patients with primary sclerosing cholangitis and ulcerative colitis [2017] [World journal of gastroenterology] [Journal] [80000752]
[1.3] Alterations of the bile microbiome in primary sclerosing cholangitis [2019] [Gut] [Journal] [80001160]
[1.4] Characterisation of the faecal microbiota in Japanese patients with paediatric-onset primary sclerosing cholangitis_DUBLICATE [2016] [Gut] [Journal] [80000335]
[1.5] Fungi participate in the dysbiosis of gut microbiota in patients with primary sclerosing cholangitis [2019] [Gut] [Journal] [80000990]
[1.6] Primary sclerosing cholangitis is characterised by intestinal dysbiosis independent from IBD [2016] [Gut] [Journal] [80000513]
[1.7] Dysbiosis of the salivary microbiota in pediatric-onset primary sclerosing cholangitis and its potential as a biomarker [2018] [Scientific Reports] [Journal] [80000746]
[1.8] The gut microbial profile in patients with primary sclerosing cholangitis is distinct from patients with ulcerative colitis without biliary disease and healthy controls [2017] [Gut] [Journal] [80000516]
[1.9] The mucosa-associated microbiota of PSC patients is characterized by low diversity and low abundance of uncultured Clostridiales II [2015] [Journal of Crohn's and Colitis] [Journal] [80000509]

Disease ⇒ Primary sclerosing cholangitis {40000179}

Record Keys

Details

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Meta Information

Notes:

References Notes

Shared Reference Notes

Common References