Disease ⇒ Primary sclerosing cholangitis {40000179}

Record Keys
Type:	Disease
Parent:	[ ]
Definition:	Primary sclerosing cholangitis

Details
Initialisation date:	2020-09-20
Other Terms:	PSC

Links
Wickipedia Merck Manual

Meta Information
MedDra ID:	10008609
MedDra Level:	pt
ICD:	[ ]
Category:	Rheumatology
Zone:	[ ]
Mechanism:	[ ]

Notes:

- The salivary microbial signature of PSC was significantly altered as compared to healthy controls, independent of concomitant IBD, and was comprised of 19 significantly altered species, of which, eight species were consistently overrepresented in both fecal and saliva of patients with PSC, including Veillonella, Scardovia and Streptococcus. (1)

References Notes

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Shared Reference Notes

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↥ Microbiota

‐ Bacteroides Stool Human [1.1]
‐ Clostridium Stool Human [1.2]
‐ Enterococcus faecalis Bile Human [1.3]
‐ Enterococcus faecium Stool Human [1.4]
‐ Enterococcus sp. NBRC 107345 Stool Human [1.4]
‐ Enterococcus Stool Human [1.4]
‐ Enterococcus Tissue biopsie Human [1.3]
‐ Escherichia coli Tissue biopsie Human [1.3]
‐ Exophiala Stool Human [1.5]
‐ Fusobacterium Stool Human [1.6]
‐ Haemophilus Stool Human [1.2]
‐ Lactobacillus Stool Human [1.6]
‐ Morganella Stool Human [1.6]
‐ Neisseria Tissue biopsie Human [1.3]
‐ Oribacterium Saliva Human [1.7]
‐ Parabacteroides Stool Human [1.1]
‐ Rothia mucilaginosa Stool Human [1.2]
‐ Scardovia Oral & Gut Lumen Human
‐ Staphylococcus Tissue biopsie Human [1.3]
‐ Streptococcus alactolyticus Stool Human [1.2]
‐ Streptococcus equi Stool Human [1.2]
‐ Streptococcus infantis Stool Human [1.2]
‐ Streptococcus parasanguinis Stool Human [1.4]
‐ Streptococcus Oral & Gut Lumen Human
‐ Streptococcus Stool Human [1.6]
‐ Veillonella dispar Bile Human [1.3]
‐ Veillonella dispar Stool Human [1.2]
‐ Veillonella dispar Tissue biopsie Human [1.3]
‐ Veillonella parvula Stool Human [1.2]
‐ Veillonella Oral & Gut Lumen Human
‐ Veillonella Stool Human [1.4]

↧ Microbiota

‐ Adlercreutzia equolifaciens Stool Human [1.2]
‐ Anaerostipes Stool Human [1.6]
‐ Blautia obeum Stool Human [1.4]
‐ Blautia Stool Human [1.5]
‐ Christensenellaceae Stool Human [1.8]
‐ Coprococcus catus Stool Human [1.2]
‐ Coprococcus Stool Human [1.8]
‐ Desulfovibrio Stool Human [1.8]
‐ Faecalibacterium prausnitzii Stool Human [1.2]
‐ Faecalibacterium Stool Human [1.5]
‐ Haemophilus Saliva Human [1.7]
‐ Lachnoclostridium Stool Human [1.5]
‐ Lachnospiraceae Stool Human [1.8]
‐ Parabacteroides distasonis Stool Human [1.4]
‐ Parabacteroides Stool Human [1.4]
‐ Phascolarctobacterium Stool Human [1.8]
‐ Prevotella copri Stool Human [1.2]
‐ Rothia Saliva Human [1.7]
‐ Ruminiclostridium Stool Human [1.5]
‐ Ruminococcus gnavus Stool Human [1.2]
‐ Ruminococcus Stool Human [1.5]
‐ Saccharomyces cerevisiae Stool Human [1.5]
‐ Succinivibrio Stool Human [1.8]
‐ uncultured Clostridiales II Mucosal biopsies of colon Human [1.9]

↥ Metabolome

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↧ Metabolome

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Related Factor

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Subclass

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References

(1) [Abstract] [2020] Alterations of the salivary and fecal microbiome in patients with primary sclerosing cholangitis

Author: MetaBiom
Identifier: 40000179
URL: https://www.metabiom.org/disease/79/primary-sclerosing-cholangitis
Keywords: Microbiome, Dysbiosis, Chronic

Common References

[1.1] Consistent alterations in faecal microbiomes of patients with primary sclerosing cholangitis independent of associated colitis [2019] [Alimentary Pharmacology & Therapeutics] [Journal] [80001214]
[1.2] Distinct gut microbiota profiles in patients with primary sclerosing cholangitis and ulcerative colitis [2017] [World journal of gastroenterology] [Journal] [80000752]
[1.3] Alterations of the bile microbiome in primary sclerosing cholangitis [2019] [Gut] [Journal] [80001160]
[1.4] Characterisation of the faecal microbiota in Japanese patients with paediatric-onset primary sclerosing cholangitis_DUBLICATE [2016] [Gut] [Journal] [80000335]
[1.5] Fungi participate in the dysbiosis of gut microbiota in patients with primary sclerosing cholangitis [2019] [Gut] [Journal] [80000990]
[1.6] Primary sclerosing cholangitis is characterised by intestinal dysbiosis independent from IBD [2016] [Gut] [Journal] [80000513]
[1.7] Dysbiosis of the salivary microbiota in pediatric-onset primary sclerosing cholangitis and its potential as a biomarker [2018] [Scientific Reports] [Journal] [80000746]
[1.8] The gut microbial profile in patients with primary sclerosing cholangitis is distinct from patients with ulcerative colitis without biliary disease and healthy controls [2017] [Gut] [Journal] [80000516]
[1.9] The mucosa-associated microbiota of PSC patients is characterized by low diversity and low abundance of uncultured Clostridiales II [2015] [Journal of Crohn's and Colitis] [Journal] [80000509]

Disease ⇒ Primary sclerosing cholangitis {40000179}

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Notes:

References Notes

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Common References