Disease ⇒ Primary sclerosing cholangitis {40000179} Record Keys Type:Disease Parent:[ ] Definition:Primary sclerosing cholangitis Details Initialisation date:2020-09-20 Other Terms:PSC LinksWickipediaMerck Manual Meta Information MedDra ID:10008609 MedDra Level:pt ICD:[ ] Category:Rheumatology Zone:[ ] Mechanism:[ ] Notes: - The salivary microbial signature of PSC was significantly altered as compared to healthy controls, independent of concomitant IBD, and was comprised of 19 significantly altered species, of which, eight species were consistently overrepresented in both fecal and saliva of patients with PSC, including Veillonella, Scardovia and Streptococcus. (1)Shared Reference Notes [1.1] - The aggregated relative abundance of #Klebsiella species was significantly higher in patients with #Crohn’s disease and primary sclerosing cholangitis when compared with healthy controls. - Several genes increased in the faecal microbiomes of patients with inflammatory bowel diseases > include hemolysin-coregulated protein and enzymes involved in fructose-, galactitol-, mannose-, and long-chain fatty acid-related uptake and metabolic pathways- were enriched in most faecal samples of the patients with inflammatory disease who carried #Klebsiella species. [1.2] - #Veillonella extensively participates in a range of diseases associated with gastrointestinal microbial dysbiosis, for instance, hepatic and gall diseases (#Autoimmune hepatitis, #Alcoholic Hepatitis, #Biliary atresia, and PSC) [#Roseomonas mucosa, #Streptococcus salivarius] - Even in the early stages, PSC patients’ stool and mucosa significantly enrich oral pathogenic bacteria such as #Streptococcus, #Veillonella, and #Actinomyces (#Streptococcus salivarius is an independent predictor of liver-related three-year mortality) [1.3] [#Prevotella copri] - In primary sclerosing cholangitis, a liver disease coupled with inflammation in the bile ducts, P. copri was negatively correlated with the disease, especially in patients with concurrent inflammatory bowel disease. - Enriching the gut microbiota with P. copri was shown to decrease cholestasis and #Liver fibrosis. [1.4] [#Inflamatory bowel disease, #Intrahepatic Cholangiocarcinoma] - IBD has been reported to positively affect the incidence of cholangiocarcinoma. - the association may not be direct and instead occur through the mediation of primary sclerosing cholangitis [1.5] - Primary sclerosing cholangitis (PSC), an immune-associated cholangitis, is linked to a heightened risk of cholangiocarcinoma and #Gallbladder cancer - Patients with PSC display disruptions in the upper digestive tract and bile duct microbiota. - Biliary dysbiosis is correlated with elevated levels of the proinflammatory and potentially cancerogenic agent #Taurolithocholic acid [1.6] [#Inflamatory bowel disease] - #Smoking increased risk of EIMs except for PSC, where there was a “protective” effect. - Multiple serologic associations were observed, including with PSC (IgG and IgA, perinuclear anti-nuclear cytoplasmic antibody; anti-#Saccharomyces cerevisiae antibodies; and anti-#Flagellin) and any EIM (IgG and IgA, perinuclear anti-nuclear cytoplasmic antibody; anti-#Saccharomyces cerevisiae antibodies; and anti–#Pseudomonas fluorescens-associated sequence). References Notes[ ]
