Desulfovibrionaceae ⇒ Bilophila {10001066}

Shared Reference Notes

• [1.1] 
  - Bilophila, was found to be increased in RA and positively associated with the branched chain amino acid alloisoleucine and the lysine metabolite, 2-aminoadipate
• [1.2] [#Atherosclerosis, #Coronary artery disease] 
  - Bilophila, a genus of gut microbes, can metabolize #TMA, resulting in lower #TMAO, suggesting that differences in #TMA-metabolizing gut bacteria in individuals lead to different ultimate effects, and replacement of relevant bacteria may reduce the risk from #TMAO.
• [1.3] [#Behcet’s Disease] [#Butyrate, #Lactate, #Lipopolysaccharide] 
  - These results showed that the gut microbiota in BD patients was enriched with lactic acid-producing bacteria, #Sulfate-reducing bacteria, and some opportunistic pathogens but lacked #Butyric acid-producing bacteria and methanogenic bacteria. - In mice receiving BD feces, it was observed that the intestinal barrier was disrupted with low expression of tight-junction proteins, leading to LPS release into circulation. - enrichment of Bilophila, Alistipes, and #Paraprevotella was observed in the BD-recipient group.
• [1.4] 
  - in neurodegenerative disease > The microbes with elevated populations, like Bilophila, Butryicicoccus, #Alistipes, #Enterococcus, #Lactobacillus, #Streptococcus, #Shigella, and #Desulfovibrio, have the metabolic capability to produce #Putrescine majorly by the #Putrescine III biosynthesis pathway.
• [1.5] [#Behcet’s Disease] 
  - Depleted #Dorea, #Blautia, #Coprococcus, #Erysipelotrichaceae and #Lachnospiraceae as well as enriched Bilophila and #Stenotrophomonas were identified in BU patients.
• [1.6] [#Clostridium cluster IV] 
  - TNF-α was found to be positively correlated with the abundance of #Parabacteroides, Bilophila, and #Clostridium IV, but negatively correlated with the abundance of #Prevotella.
• [#Lipopolysaccharide, #TNF-alfa] - In healthy individuals, Bilophila was negatively correlated with LPS-induced production of TNF-α
• [1.7] 
  - #Behcet’s Disease > Stool samples were enriched with #Parabacteroides, sulphate-reducing bacteria Bilophila and #Desulfovibrionaceae species. In addition, it was also noted that #Butyrate-producing bacteria #Clostridium and methanogens were reduced. - Transplantation of BD faeces in mice illustrated remarkable results in which gut integrity was breached due to decreased expression of tight junctions, with the subsequent effects of experimental uveitis.
• [1.8] [#Animal-based diet, #Animal fat consumption] 
  - animal-based diets (typically called a “Western” diet with high amounts of animal fat and protein, and processed carbohydrates) induce decreased levels of beneficial species within the #Firmicutes phyla and strains from the genus #Prevotella; while levels of bile-tolerant, inflammation-associated #Proteobacteria, such as Bilophila, and #Bacteroides are increased
• - #Inulin as a #Prebiotic > increased #Bifidobacterium and #Faecalibacterium prausnitzii, and decreased Bilophila after #Inulin digestion by human volunteers
• [1.9] [#Creutzfeldt–Jakob disease] [#Christensenellaceae] 
  - Several bacteria taxa in sCJD patients were increased at genus level, such as #Turicibacter, norank_f_Christensenellaceae, #Eisenbergiella, Bilophila and #Holdemania.
• [#Inflamatory bowel disease] [#Escherichia coli] - #Colectomy > there was a significant increase in the expansion of E.coli in individuals who underwent surgery and, in particular, samples from IBD patients who underwent #Colectomy had the highest abundance of E.coli. - At 6 months, endoscopic recurrence was associated with elevated #Proteus genera and at 18 months with reduced #Faecalibacterium, #Desulfovibrio and Bilophila abundance. At 18 months severe endoscopic recurrence was associated with increase in #Proteobacteria.
• [1.11] [#High Fat Diet] 
  - #Blautia (e.g., ASV24) and Bilophila (e.g., ASV37) which had been observed with increased abundance upon HFD feeding

References Notes