Microbiome & Chronic Diseases

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Bilophila ⇒ Bilophila wadsworthia {10001322}

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Bilophila wadsworthia


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References Notes

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Shared Reference Notes

  • [1.6
    -Bilophila wadsworthia ultimately produces hydrogen sulfide from DHPS via a metabolic pathway that was also only recently discovered,
  • [1.7] [#Inflamatory bowel disease
    - Diet rich in high saturated fats promotes chronic inflammation. - One explanation is that the amino acid #Taurine, present in saturated fats, linked to bile acids, seems to increase substrate availability for sulfur-reducing bacteria like Bilophila Wadsworthia, highly prevalent in the dysbiotic microbiota of IBD patients.
  • [1.8] [#Cognitive impairment] [#Keto diet
    - Carbohydrate-restricted (ketogenic) diet potentiates CI induced by intermittent hypoxia in mice and alters the gut microbiota. - Depleting the microbiome reduces CI, whereas transplantation of the risk-associated microbiome or monocolonization with Bilophila wadsworthia confers CI in mice fed a standard diet. - B. wadsworthia and the risk-associated microbiome disrupt hippocampal synaptic plasticity, neurogenesis, and gene expression. - The CI is associated with microbiome-dependent increases in intestinal interferon-gamma (IFNg)-producing Th1 cells. - Inhibiting Th1 cell development abrogates the adverse effects of both B. wadsworthia and environmental risk factors on CI.
  • [1.9] [#Parkinson’s Disease
    - B. Wadsworthia > large quantities in PD patients > increased #Sulfite production in the intestine. - #Sulfite > neurotoxin > mediates the mitochondrial energy balance of the brain
  • [1.10
    - There was a relative enrichment of taurine-conjugated compared to glycine-conjugated and non-conjugated #Bile Acids during #Pregnancy, accompanied by expansion of taurine respirer Bilophila wadsworthia, which has been linked to colitis and glucose dysmetabolism

Common References