Microbiome & Chronic Diseases

Evidence Based Medicine
Sign in

Disease ⇒ Hepatocellular cancer {40000356}

Record Keys

Parent:[  ]
Hepatocellular cancer


Initialisation date:[  ]
Other Terms:

Meta Information

MedDra ID:
MedDra Level:
ICD:[  ]
Category:[  ]
Zone:[  ]
Mechanism:[  ]


[  ]

Shared Reference Notes

  • [1.1
    - Immune reactivity against E. hirae or B. longum also correlates with robust CD8+ T cell responses and better prognosis in HBV-related hepatocellular carcinoma
  • [1.2
    - hepatocellular carcinoma patients had significantly decreased #Linoleic acid and #Phenol levels in serum and feces, two metabolites that significantly inhibit the growth of hepatocellular carcinoma cells.
  • [1.3
    - Coprococcus and Faecalibacterium were depleted in hepatocellular carcinoma.
  • [1.4
    - #Fusobacterium nucleatum was found to directly interact with TIGIT through the FAP2 protein, with subsequent inhibition of NK cells which have significant anti-tumor properties
  • [1.5] [#Secondary bile acids
    - excessive production of the secondary BA deoxycholic acid triggers the expression of inflammatory and tumorigenic factors in hepatic stellate cells (HSCs), contributing to hepatocellular carcinoma development. Secondary BAs might also activate farnesoid X receptor (FXR) and elevate the risk of developing #Colorectal cancer and hepatocellular carcinoma.
  • [1.6
    - hepatocellular carcinoma > #Prevotella was enriched in patients with Progressive Disease. - hepatocellular carcinoma > #Lachnoclostridium, #Lachnospiraceae, and #Veillonella were predominant in patients with objective responses.
  • - hepatocellular carcinoma > The coexistence of #Lachnoclostridium enrichment and #Prevotella 9 depletion significantly predicted better overall survival (OS)
  • - hepatocellular carcinoma > #Ursodeoxycholic acid and #Ursocholic acid were significantly enriched in the feces of patients with objective responses and strongly correlated with the abundance of #Lachnoclostridium.
  • [1.7] [#Bacteroides-Prevotella group, #Clostridium clusters XIVa
    - levels of #Bacteroides, #Lachnospiracea #Incertae sedis, and #Clostridium XIVa were higher in the gut of non-small-cell HCC group (higher tumor load) and could separate the non-small-cell liver cancer group from small-cell HCC group (lower tumor load)
  • - increased levels of genus #Odoribacter and #Butyricimonas but decreased levels of genus #Dorea in the gut of HCC patients compared to those without HCC and identified them as potential biomarkers of HCC
  • [#Short Chain Fatty Acid] - Probiotics also increase bacteria that produce SCFA, such as #Butyricimonas and #Prevotella, and prevent HBV and HCV infections, thereby reducing HCC progression
  • - a few microbial genera were related to HCC tumor size, of which three (#Enterococcus, #Limnobacter, and #Phyllobacterium) could be used as markers for the early diagnosis of HCC
  • [1.8] [#Diabetes Type 2, #Non-alcoholic fatty liver disease
    - Among people with NAFLD, the presence of type 2 diabetes is associated with a significantly higher risk of hepatic decompensation and hepatocellular carcinoma.

References Notes

[  ]

Common References