Linoleic acid {90000294}

Record Keys


Parent:[  ]
Definition:
Linoleic acid
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Details


Initialisation date:[  ]
Specification:
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Source:
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Meta Information


Structural Type:[  ]
Functional Type:[  ]
Function:
Anti-cancer

Notes:


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Shared Reference Notes


  • [1.1] [#Hepatocellular cancer
    - hepatocellular carcinoma patients had significantly decreased linoleic acid and #Phenol levels in serum and feces, two metabolites that significantly inhibit the growth of hepatocellular carcinoma cells.
  • [1.2] [#Omega 3
    - After 10 weeks of omega-3 fatty acid or γ-linoleic acid supplementation, inflammatory and non-inflammatory #Acne lesions decreased significantly.
  • [1.3] [#Cancer
    - Linoleic acid (LA) is a major positive regulator of CTL ( Cytotoxic T Cell Lymphocytes ) activity by improving metabolic fitness, preventing exhaustion, and stimulating a memory-like phenotype with superior effector functions. - LA potentiates antitumor CTL response.
  • [1.4] [#Soybean
    - Soybeans also contain higher amounts of polyunsaturated fatty acids, including both omega-6 and omega-6 essential fatty acids, linoleic acid and alpha-linolenic acid, than other common legumes
  • [1.5
  • [1.6] [#Creutzfeldt–Jakob disease
    - metabolites in sCJD, related to linoleic acid metabolism and steroid hormone biosynthesis might be biomarkers of evaluating disease severity.
  • [1.7
    - linoleic acid, a fatty acid required for acylceramide synthesis and essential for corneocyte lipid envelope formation. - This fatty acid is decreased in the epidermis in patients with ichthyosis, and #Acne-prone patients have low concentrations of linoleic acid and a relative lack of ceramide.
  • [#Cutibacterium acnes] - lipidomic analyses showed an increase of triglycerides containing linolenic acid (TAG18:2) and an increase of total ceramide in NHEKs after C. acnes exposure. - linoleic acid may be hydrolyzed from TAG and then contribute to acylceramide synthesis to maintain skin barrier function.
  • [#Cutibacterium acnes] - Linoleic acid in NHEK lipid extract could partially explain the increased potency for C. acnes inhibition and has previously been shown to directly inhibit the growth of C. acnes

References Notes


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