Lachnospiraceae ⇒ Dorea {10000312}

Shared Reference Notes

• [1.1] [#Inflamatory bowel disease] 
  - Dorea belongs to the Lachnospiraceae family, which was recently associated with IBD and which is also found in IBD patients with low short-chain fatty acid butyrate.
• [1.2] 
  - Dorea is consistently associated with advanced MAFLD and #Steatohepatitis
• [1.3] [#Gastric bypass surgery] 
  - #Lactococcus, #Streptococcus, and #Granulicatella are #Lactate-producing microorganisms, whereas Dorea and #Blautia are #Lactate oxidizers
• [1.4] [#Crohn’s disease] [#Clostridium cluster IV] 
  - #Roseburia, #Gemmiger, #Coprococcus, #Ruminococcus 2, #Butyricicoccus, Dorea, #Fusicatenibacter, #Anaerostipes, Clostridium IV were enriched in the healthy controls. - #Blautia, Clostridium IV, #Coprococcus, Dorea, #Fusicatenibacter continued to significantly decrease in early and advanced CD patients, and Escherichia/Shigella and Proteus continued to significantly increase. - negative correlation between Dorea, #Butyricicoccus, #Roseburia and gland reduce, #Roseburia and FC, #Butyricicoccus and goblet cells decreased, Parabacterodies and sex, Clostridium IV and CRP, Dorea and ESR . - positive correlation between Escherichia/Shigella and CRP, #Ruminococcus 2 and clinical symptoms.
• [1.5] [#Behcet’s Disease] 
  - Depleted Dorea, #Blautia, #Coprococcus, #Erysipelotrichaceae and #Lachnospiraceae as well as enriched #Bilophila and #Stenotrophomonas were identified in BU patients.
• [#Vogt-Koyanagi-Harada] - An enriched #Alistipes along with a lower level of Dorea were observed in VKH patients.
• [1.6] [#Crohn’s disease] [#Dorea longicatena, #Ruminococcus lactaris] 
  - ileocolonic resection (ICR) in CD patients > amples collected at time of surgery were enriched in #Proteobacteria and harbored high levels of unusual, bacteria such as #Streptococcus mitis, #Undibacterium oligocarboniphilum, #Sphingomonas melonis and #Gemella haemolysans - 6 months after surgery samples had elevated proportions of anaerobic bacteria belonging to #Lachnospiraceae (#Clostridium nexile, #Blautia wexlereae, Dorea longicatena). - Remission was characterized by increased levels of bacteria belonging to #Bacteroides, Dorea, #Ruminococcus and #Dialister genera, whereas recurrence was associated with increased levels of #Gemmiger formicilis, #Enterococcus durans and #Ruminococcus lactaris.
• [1.7] [#Irritable bowel syndrome] 
  - IBS was typified by enhanced quantities of #Firmicutes and specifically in #Ruminococcus, #Clostridium, and Dorea, along with a distinct decrease of beneficial microbes, such as #Bifidobacterium and #Faecalibacterium spp
• [1.8] [#Non-alcoholic fatty liver disease] 
  - An increase in Dorea, combined with decreases in #Alistipes appears to be characteristic of MAFLD patients.
• [#Non-alcoholic fatty liver disease] - the abundance of Dorea was found to be significantly overrepresented in the MAFLD patients and the degree of enrichment increased with the increasing abnormal liver enzyme.
• [#Non-alcoholic fatty liver disease] - Dorea, #Lactobacillus and #Megasphaera are enriched in MAFLD group.
• [1.9] 
  - #Blautia, #Faecalibacterium, and Dorea levels were consistently more abundant in 8-year-olds with #Allergy than in #Children without #Allergy. - #Faecalibacterium abundance was correlated with IL-10 and FOXP3 mRNA levels.
• [#Obesity] [#Collinsella aerofaciens] - subjects with BMI values ≥25 kg/m2 have higher relative abundances of members of the #Collinsella genus (e.g., #Collinsella aerofaciens), and the #Veillonellaceae and #Lachnospiraceae families (e.g., genera Dorea, #Lachnospira, #Coprococcus).
• [1.11] [#Bipolar disorder] 
  - Abundance of #Bacilli, #Lactobacillales and genus #Veillonella were higher in BD patients than in HCs, while genus Dorea was more abundant in HCs. - bacterial genera’ abundance in BD patients was strongly correlated with the severity of #Depression and inflammatory markers.
• [#Bipolar disorder] - #Serum CRP concentration was positively correlated with #Prevotella abundance, but negatively correlated with #Butyricicoccus, #Lachnospiraceae incertae sedis and Dorea abundance in BD patients.
• - #Blautia, Fecalibacterium, and Dorea were found to be related to cognition function and could alleviate the inflammatory reaction in #Cirrhosis patients
• [1.12] [#Clostridiales XIV, #Clostridium cluster IV] 
  - #Walnut consumption at 42 g/day, increased #Butyrate-producing #Clostridium clusters XIV and IV including, #Faecalibacterium, #Roseburia, while lowering the relative abundance of #Ruminococcus, Dorea, Oscilllo, #Bifidobacteria.
• [1.13] [#Hepatocellular cancer] 
  - increased levels of genus #Odoribacter and #Butyricimonas but decreased levels of genus Dorea in the gut of HCC patients compared to those without HCC and identified them as potential biomarkers of HCC
• [1.14] 
  - #HDL had a positive association with Elusimicrobium and #Ezakiella, whereas Dorea and #Blautia were negatively associated with #Glucose
• [1.15] [#Multiple Sclerosis] 
  - Individuals with relapsing-remitting MS have an abundance of #Mycoplasma, #Pseudomonas, #Faecalibacterium, #Haemophilus, #Anaerostipes, #Blautia, and Dorea, while #Bacteroides, #Prevotella, #Parabacteroides, and #Adlercreutzia are relatively less common.
• [1.16] [#Osteopontin] 
  - OPN could reduce the colonization of #Lactobacillus in the intestine of mice and promote the abundance of Dorea, which could further regulate metabolic disorders

References Notes