Disease ⇒ Metabolic syndrome ⇒ Prediabetes {40000332}

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Shared Reference Notes

  • [1.1] [#High Fat Diet
    - microbiota protects against development of #Obesity, #Metabolic syndrome, and pre-diabetic phenotypes by inducing commensal-specific Th17 cells. - High-fat, high-#Sugar diet promoted metabolic disease by depleting Th17-inducing microbes, and recovery of commensal Th17 cells restored protection. - Diet-induced loss of protective Th17 cells was mediated by the presence of #Sugar. - Eliminating #Sugar from high-fat diets protected mice from #Obesity and #Metabolic syndrome in a manner dependent on commensal-specific Th17 cells. - #Sugar and ILC3 promoted outgrowth of #Faecalibaculum rodentium that displaced Th17-inducing microbiota.
  • [1.2
    - patients with prediabetes had significantly lower levels of #Butyrate bacteria than healthy people.
  • [1.3] [#Diabetes Type 2] [#Ruminococcus gnavus
    - R. gnavus showed significantly higher abundance in patients with type 2 diabetes mellitus (T2DM) and prediabetes (PreDM).
  • [1.4] [#Short Chain Fatty Acid
    - adults with prediabetes > #Metformin > increased the abundance of GM SCFA-producing bacteria M (#Fusicatenibacter and #Blautia) - adults with prediabetes > linagliptin/#Metformin > Roseburia, Bifidobacterium, and [Eubacterium] hallii group.

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