MetaBiom
Microbiome & Chronic Diseases

Evidence Based Medicine
Sign in

Disease ⇒ Metabolic syndrome ⇒ Prediabetes {40000332}

Record Keys


Type:
Disease
Parent:
Definition:
Prediabetes

Details


Initialisation date:[  ]
Other Terms:[  ]

Meta Information


MedDra ID:
10065542
MedDra Level:
llt
ICD:[  ]
Category:[  ]
Zone:[  ]
Mechanism:[  ]

Notes:


[  ]

References Notes


[  ]

Shared Reference Notes


  • [1.2] [#High-fat diet
    - microbiota protects against development of #Obesity, #Metabolic syndrome, and pre-diabetic phenotypes by inducing commensal-specific Th17 cells. - High-fat, high-#Sugar diet promoted metabolic disease by depleting Th17-inducing microbes, and recovery of commensal Th17 cells restored protection. - Diet-induced loss of protective Th17 cells was mediated by the presence of #Sugar. - Eliminating #Sugar from high-fat diets protected mice from #Obesity and #Metabolic syndrome in a manner dependent on commensal-specific Th17 cells. - #Sugar and ILC3 promoted outgrowth of #Faecalibaculum rodentium that displaced Th17-inducing microbiota.
  • [1.3
    - patients with prediabetes had significantly lower levels of #Butyrate bacteria than healthy people.