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Disease ⇒ Metabolic syndrome {40000421}

Record Keys


Type:
Disease
Parent:[  ]
Definition:
Metabolic syndrome

Details


Initialisation date:[  ]
Other Terms:[  ]

Meta Information


MedDra ID:
10052066
MedDra Level:
llt
ICD:[  ]
Category:[  ]
Zone:[  ]
Mechanism:[  ]

Notes:


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References Notes


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Shared Reference Notes


  • [1.1
    - Oral supplementation with the alive A. Mucinophila prevente the reduction of 2-PG and 1-PG levels observed upon the progression of the metabolic syndrome.
  • [1.5
    - The protective association between adherence to the #Mediterranean diet and cardiometabolic disease risk is significantly stronger among participants with decreased abundance of #Prevotella copri.
  • [1.6] [#Dysosmobacter welbionis
    - D. welbionis abundance was present in up to 70% of the general population. Furthermore, its absolute abundance in the fecal microbiota of people with obesity suffering from metabolic syndrome was inversely correlated with body mass index, fasting glucose and glycated hemoglobin. which is used to determine how well a person with diabetes has been managing their blood sugar over the previous months.
  • [1.7] [#Obesity] [#Fecal Microbiota Transplantation, #High-fiber diet
  • [1.9] [#Elevated C-reactive protein, #Low high-density lipoprotein cholesterol
    - Higher long-term PDI (#Plant-based diet index) was associated with the lower relative abundance of #Peptostreptococcus, while this microbe was positively correlated with the high-sensitivity C-reactive protein and inversely associated with high-density lipoprotein cholesterol.
  • - MetS gut viromes exhibit decreased richness and diversity. They are enriched in phages infecting Streptococcaceae and Bacteroidaceae and depleted in those infecting Bifidobacteriaceae. - MetS-associated Roseburia VC (viral cluster) that is related to healthy control-associated Faecalibacterium and Oscillibacter VCs.
  • - #Candidatus Heliusviridae, a highly widespread gut phage lineage found in 90+% of Metabolic syndrome participants.
  • [1.11] [#Omega 3] [#Western-style diet
    - nutritional enrichment of WD with #Fish oil n-3PUFA can partially mitigate its detrimental effects, potentially improving the low-grade inflammation associated with immune metabolic disease.
  • [1.12] [#Prediabetes] [#High-fat diet
    - microbiota protects against development of #Obesity, metabolic syndrome, and pre-diabetic phenotypes by inducing commensal-specific Th17 cells. - High-fat, high-#Sugar diet promoted metabolic disease by depleting Th17-inducing microbes, and recovery of commensal Th17 cells restored protection. - Diet-induced loss of protective Th17 cells was mediated by the presence of #Sugar. - Eliminating #Sugar from high-fat diets protected mice from #Obesity and metabolic syndrome in a manner dependent on commensal-specific Th17 cells. - #Sugar and ILC3 promoted outgrowth of #Faecalibaculum rodentium that displaced Th17-inducing microbiota.
  • [1.13
    - #Curcumin may decrease risk of developing metabolic diseases associated with chronic inflammation.

Common References