Faecalibaculum rodentium ⇒ Pseudomonadaceae {10000169}

References Notes

Shared Reference Notes

• [1.1] [#Breast cancer] [#Antibiotic Therapy] 
  - Antibiotic-induced perturbation of the gut microbiota > increases tumor progression in multiple BrCa mouse models > increased number of cells with a stromal signature in tumors > increased abundance of mast cells in the tumor stromal regions. - Re-supplementation of antibiotic-treated mice with Faecalibaculum rodentium > restored tumor growth to control levels - Mast cell stabilizer, #Cromolyn > decreases tumor growth only in antibiotic treated animals
• [1.2] [#Prediabetes] [#High-fat diet] 
  - microbiota protects against development of #Obesity, #Metabolic syndrome, and pre-diabetic phenotypes by inducing commensal-specific Th17 cells. - High-fat, high-#Sugar diet promoted metabolic disease by depleting Th17-inducing microbes, and recovery of commensal Th17 cells restored protection. - Diet-induced loss of protective Th17 cells was mediated by the presence of #Sugar. - Eliminating #Sugar from high-fat diets protected mice from #Obesity and #Metabolic syndrome in a manner dependent on commensal-specific Th17 cells. - #Sugar and ILC3 promoted outgrowth of Faecalibaculum rodentium that displaced Th17-inducing microbiota.