Disease ⇒ Migraine {40000136}

Shared Reference Notes

• [1.1] 
  - These results suggest that bacteria in the mouth may therefore contribute to efficient breakdown of nitrate contained in foods and food preservatives, which are finally converted into nitric oxide in the bloodstream, causing vessels in the brain and scalp to dilate. Pseudomonas have the potential to reduce nitrate. - Streptococcus and Pseudomonas, both of which have species with the potential to reduce nitrate.
• [1.2] [#Celiac Disease] [#CGRP, #Glutamate, #Serotonin] 
• [1.3] [#Crohn’s disease, #Inflamatory bowel disease, #Ulcerative Colitis] 
  - The incidence of IBD was significantly higher in patients with migraine, CD and UC than in those without migraine. - After 5 years of follow-up, those with migraine showed curves implying cumulative incidences of IBD with a steep increase, especially for CD.
• [1.4] 
  - chronic headache patients presented higher #Histamine concentrations than healthy subjects, either during or between migraine attacks
• - low levels of cerebral #Serotonin were strongly associated with migraine. - migraineurs have higher levels of cerebral #Serotonin during an acute pain attack compared with the periods between attacks
• [1.5] 
  - H. pyloriis exposed to fairly high concentrations of NO in gastric juice, which has low oxygen tension. - NO directly inhibits the respiration of E. coli whereas it rapidly reacts with endogenously generated superoxide radicals in H. pylori. The resulting peroxynitrite inactivates the respiration of H. pylori.
• [1.6] [#Crohn’s disease, #Inflamatory bowel disease] 
  - The cumulative risk of IBD showed a gradual increase following a diagnosis of migraine and, especially for CD, a steep rise after 5 years of follow-up in migraineurs.
• [#Diabetes Type 2] - #Metabolic syndrome, which involves a number of factors including HTN, #Hyperlipidemia, #Obesity, and insulin resistance, is more frequently reported in patients with migraine
• [#Inflamatory bowel disease] - the risk for the development of IBD in migraineurs was significantly higher at 1.3-fold compared to the general population.
• [#Inflamatory bowel disease] [#Alcohol Consumption, #Dark chocolate, #Meat-based diet] - diet with citrus fruit, processed meat, #Gluten, chocolate, #Coffee, and alcoholic beverages are pointed out as dietary risk factors for both migraine and IBD in several studies
• [1.7] 
  - Subjects affected by primary headache have a H. pylori infection prevalence of 40%. - It also found a higher prevalence of migraine without aura in infected patients. - Higher IgM antibody titers against H. pylori in PWM compared to controls. - A positive correlation between IgG antibody titers and severity of migraine. - The serum levels of CGRP, which has been suggested as a biomarker for chronic migraine are also higher in those with H. pylori-associated duodenal ulcers compared with healthy controls.

References Notes