CGRP {90000342} Record Keys Parent:[ ] Definition:CGRP Queue:[ ] Details Initialisation date:[ ] Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Celiac Disease, #Migraine] [#Glutamate, #Serotonin] [1.2] - #Capsaicin, the ingredient in #Chili peppers found in spicy foods, also induced neurons to produce CGRP and induce mucus production by the gut. - Headaches and migraines > taking drugs to block CGRP or its receptor RAMP1 > blocking this pathway could lead to gut barrier problems, including mucus production and potentially also microbiome problems. - It is already known that blocking CGRP can lead to #Constipation in the gut. - #Pain signaling > neurons used a signal called CGRP to communicate with goblet cells > produce mucus. - Gut microbes are one factor that causes neurons to produce CGRP and induce goblet cells to produce mucus. - mice that lacked either nociceptor neurons or CGRP were more susceptible to colitis. References Notes[ ]
