Disease ⇒ Constipation {40000270}
Type: | Disease |
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Parent: | [ ] |
Definition: | Constipation |
Initialisation date: | 2021-02-11 |
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Other Terms: | [ ] |
MedDra ID: | 10010774 |
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MedDra Level: | pt |
ICD: | [ ] |
Category: | Gastroenterology |
Zone: | [ ] |
Mechanism: | [ ] |
Notes:
- Constipation may predispose to different dysbiome related to other chronic diseases.
Shared Reference Notes
- [1.1] [#Consumption of Magnesium oxid]
- Mg2+ oxide > Decrease in stool consistency and suppressed presence of the genus #Dialister - [1.2] [#Parkinson’s Disease]
- #Tryptophan, an essential amino acid only derived from microbiome or diet, is the rate limiting precursor to #Serotonin. #Tryptophan biosynthesis pathway was reduced in PD. - spore forming bacteria modulate #Serotonin production and enhance gut motility - constipation, a common symptom of PD, may be related to the depletion of spore forming bacteria. - [1.3] [#Serotonin, #Short Chain Fatty Acid]
- gut microbiota may promote the development of functional constipation through microbial metabolites, including #Bile Acids, SCFAs, 5-hydroxytryptamine, and #Methane. - [1.4] [#Alzheimer’s disease]
- constipation significantly correlated with a steeper decline in cognitive function and greater increase in DWML volume in patients with AD and aMCI. - higher level of serum #Homocysteine was observed in those with constipation. - patients with constipation experienced cognitive decline at a rate over twice that experienced by patients without constipation. - - constipation may not be a necessary condition for steeper cognitive decline. Rather, a condition without constipation may support a relatively slow decline in #Cognitive impairment.
- - constipation could trigger structural changes in the microbiome and conversely, alteration of microbiome was reported to induce constipation.
- [1.5] [#Irritable bowel syndrome]
- #Gastroparesis (delayed stomach emptying), #Dysphagia (difficulty swallowing), and constipation were associated with over double the risk of #Parkinson’s Disease in the 5 years preceding the diagnosis, while IBS without #Diarrhea was associated with a 17 per cent higher risk - [1.6] [#Parkinson’s Disease] [#Roseomonas mucosa] [#Short Chain Fatty Acid]
- constipation severity is significantly correlated with the decrease of #Blautia and #Faecalibacterium, short chain fatty acids (SCFAs)-producing taxa that can exert positive effects on the intestinal mucosa and which are decreased in PD. - [#Parkinson’s Disease] - A previous study showed that constipation is lowest and subthreshold parkinsonism is least frequent in individuals with the #Prevotella-enriched enterotype
- [#Parkinson’s Disease] [#Short Chain Fatty Acid] - SCFAs can promote gastrointestinal motility and regulate the function of the enteric nervous system, which is why a reduction of SCFAs might contribute to the development of gastrointestinal motility disorders such as constipation in PD
References Notes
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