Disease ⇒ Constipation {40000270}

Record Keys


Type:
Disease
Parent:[  ]
Definition:
Constipation

Details


Initialisation date:
2021-02-11
Other Terms:[  ]

Meta Information


MedDra ID:
10010774
MedDra Level:
pt
ICD:[  ]
Category:
Gastroenterology
Zone:[  ]
Mechanism:[  ]

Notes:


- Constipation may predispose to different dysbiome related to other chronic diseases.

Shared Reference Notes


  • [1.1] [#Consumption of Magnesium oxid
    - Mg2+ oxide > Decrease in stool consistency and suppressed presence of the genus #Dialister
  • [1.2] [#Parkinson’s Disease
    - #Tryptophan, an essential amino acid only derived from microbiome or diet, is the rate limiting precursor to #Serotonin. #Tryptophan biosynthesis pathway was reduced in PD. - spore forming bacteria modulate #Serotonin production and enhance gut motility - constipation, a common symptom of PD, may be related to the depletion of spore forming bacteria.
  • [1.3] [#Serotonin, #Short Chain Fatty Acid
    - gut microbiota may promote the development of functional constipation through microbial metabolites, including #Bile Acids, SCFAs, 5-hydroxytryptamine, and #Methane.
  • [1.4] [#Alzheimer’s disease
    - constipation significantly correlated with a steeper decline in cognitive function and greater increase in DWML volume in patients with AD and aMCI. - higher level of serum #Homocysteine was observed in those with constipation. - patients with constipation experienced cognitive decline at a rate over twice that experienced by patients without constipation.
  • - constipation may not be a necessary condition for steeper cognitive decline. Rather, a condition without constipation may support a relatively slow decline in #Cognitive impairment.
  • - constipation could trigger structural changes in the microbiome and conversely, alteration of microbiome was reported to induce constipation.
  • [1.5] [#Irritable bowel syndrome
    - #Gastroparesis (delayed stomach emptying), #Dysphagia (difficulty swallowing), and constipation were associated with over double the risk of #Parkinson’s Disease in the 5 years preceding the diagnosis, while IBS without #Diarrhea was associated with a 17 per cent higher risk
  • [1.6] [#Parkinson’s Disease] [#Roseomonas mucosa] [#Short Chain Fatty Acid
    - constipation severity is significantly correlated with the decrease of #Blautia and #Faecalibacterium, short chain fatty acids (SCFAs)-producing taxa that can exert positive effects on the intestinal mucosa and which are decreased in PD.
  • [#Parkinson’s Disease] - A previous study showed that constipation is lowest and subthreshold parkinsonism is least frequent in individuals with the #Prevotella-enriched enterotype
  • [#Parkinson’s Disease] [#Short Chain Fatty Acid] - SCFAs can promote gastrointestinal motility and regulate the function of the enteric nervous system, which is why a reduction of SCFAs might contribute to the development of gastrointestinal motility disorders such as constipation in PD
  • [1.7] [#Parkinson’s Disease
    - A decreased abundance of #Prevotella spp. is also associated with constipation, a condition that precedes motor symptoms in PD patients by up to 20 years
  • [1.8] [#Cognitive impairment
    - Compared to those with BM once daily, participants with BM frequency every 3+ days had significantly worse objective cognitive function, equivalent to 3.0 years of chronological cognitive #Aging.
  • - #Butyrate-producing microbial species were depleted in those with less frequent Bowel Movement and worse cognition, while a higher abundance of pro-inflammatory species was associated with BM frequency of ≥twice/day and worse cognition.
  • [1.9] [#Diabetes Type 2, #Gallstone Disease, #Kidney stone, #Urinary stone disease
    - #Eggerthella, #Flavonifractor, and #Ruminococcus spp., all of which were enriched in SF, have recently been suggested as general disease-associated signatures (shared across type 2 diabetes, diarrhoea and constipation, mental disorders, and gallstones)

References Notes


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Common References


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