Disease ⇒ Urinary stone disease {40000161} Record Keys Type:Disease Parent:[ ] Definition:Urinary stone disease Details Initialisation date:2020-09-06 Other Terms:Urinary Calculi, Nephrolithiasis, Stones, Urolithiasis LinksMerck Manual Meta Information MedDra ID:[ ] MedDra Level:[ ] ICD:[ ] Zone:[ ] Mechanism:[ ] Notes: [ ]Shared Reference Notes [1.1] - Lactobacillus may inhibit stone growth. However, our multi-omics integration strongly points to three unknown metabolites. - The bacterium Oxalobacter formigenes uses oxalate as a carbon and energy source for growth, is negatively associated with both USD and urinary oxalate, is sensitive to common antibiotics, and can reduce urinary oxalate when administered orally as a probiotic, all of which implicates loss of function dysbiosis associated with this species and calcium oxalate stone formation. [1.2] [#Antibiotic Therapy] - antibiotics cause a rapid loss of gut microbial #oxalate metabolism, and while disturbed bacteria can partially recover over time, the ability to metabolize #oxalate does not. - This results in the accumulation of oxalates in the body and increases the risk of kidney stones. [1.3] [#Kidney stone] [1.4] [#Diabetes Type 2, #Gallstone Disease, #Kidney stone] - #Eggerthella, #Flavonifractor, and #Ruminococcus spp., all of which were enriched in SF, have recently been suggested as general disease-associated signatures (shared across type 2 diabetes, diarrhoea and #Constipation, mental disorders, and gallstones) [1.5] [#Kidney stone, #Urolithiasis] - no differences in the abundance of genes associated with known #oxalate degradation pathways, supporting the notion that dysfunction in other metabolic pathways plays a role in KSD. - KSD > decreased abundance of key enzymes involved in #Butyrate biosynthesis in patient intestinal microbiomes. References Notes[ ]
