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Microbiome & Chronic Diseases

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Disease ⇒ Urinary stone disease {40000161}

Record Keys


Type:
Disease
Definition:
Urinary stone disease
Parent:[  ]

Details


Initialisation date:
2020-09-06
Other Terms:
Urinary Calculi, Nephrolithiasis, Stones, Urolithiasis

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MedDra ID:[  ]
MedDra Level:[  ]
ICD:[  ]
Zone:[  ]
Mechanism:[  ]

Notes:


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References Notes


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Shared Reference Notes


  • [1.1
    - Lactobacillus may inhibit stone growth. However, our multi-omics integration strongly points to three unknown metabolites. - The bacterium Oxalobacter formigenes uses oxalate as a carbon and energy source for growth, is negatively associated with both USD and urinary oxalate, is sensitive to common antibiotics, and can reduce urinary oxalate when administered orally as a probiotic, all of which implicates loss of function dysbiosis associated with this species and calcium oxalate stone formation.
  • [1.2] [#Antibiotic Therapy
    - antibiotics cause a rapid loss of gut microbial #oxalate metabolism, and while disturbed bacteria can partially recover over time, the ability to metabolize #oxalate does not. - This results in the accumulation of oxalates in the body and increases the risk of kidney stones.

Common References