Disease ⇒ Urinary stone disease {40000161} Record Keys Type:Disease Parent:[ ] Definition:Urinary stone disease Details Initialisation date:2020-09-06 Other Terms:Urinary Calculi, Nephrolithiasis, Stones, Urolithiasis LinksMerck Manual Meta Information MedDra ID:[ ] MedDra Level:[ ] ICD:[ ] Zone:[ ] Mechanism:[ ] Notes: [ ]Shared Reference Notes [1.1] - Lactobacillus may inhibit stone growth. However, our multi-omics integration strongly points to three unknown metabolites. - The bacterium Oxalobacter formigenes uses oxalate as a carbon and energy source for growth, is negatively associated with both USD and urinary oxalate, is sensitive to common antibiotics, and can reduce urinary oxalate when administered orally as a probiotic, all of which implicates loss of function dysbiosis associated with this species and calcium oxalate stone formation. [1.2] [#Antibiotic Therapy] - antibiotics cause a rapid loss of gut microbial #oxalate metabolism, and while disturbed bacteria can partially recover over time, the ability to metabolize #oxalate does not. - This results in the accumulation of oxalates in the body and increases the risk of kidney stones. [1.3] [#Kidney stone] [1.4] [#Kidney stone] - #Vitamin A deficiency has been shown to reduce urinary #Citrate and pH, and to increase the presence of urinary calculi. - Supplementation with high amounts of #Vitamin A (retinol) in a calcium oxalate stone rat model enhanced urinary #Citrate levels, increased urinary pH, and lowered the concentration of calcium and oxalate in renal tissues [#Vitamin A] - #Children with ≤0.25 mg/l serum retinol showed impaired gut barrier function, as determined by the #Mannitol/#lactulose test. - reduced intestinal permeability could reduce #oxalate uptake and, consequently, the formation of calcium #oxalate stones.References Notes[ ]
