Irisin {90000605} Record Keys Parent:[ ] Definition:Irisin Queue:[ ] Details Initialisation date:[ ] Specification: [ ]Source: [ ] Meta Information Structural Type:[ ] Functional Type:[ ] Function:[ ] Notes: [ ]Shared Reference Notes [1.1] [#Acute Pancreatitis] - irisin levels in patients with AP were significantly lower than those in healthy controls and that the downregulation of irisin is associated with poor prognosis [#Chronic pancreatitis] - serum irisin concentration was significantly lower in patients with CP. - exogenous irisin treatment could effectively alleviate pancreatic tissue injury and the degree of pancreatic fibrosis by a reduction in the apoptosis caused by the release of the acinar cell extracellular matrix. [#Diabetes Type 1, #Gestational diabetes mellitus (GDM)] - The level of irisin was lower in patients with diabetes mellitus (DM) type 1/2 and gestational DM > may be related to the glycation effect of irisin caused by metabolic intermediates [#Diabetes Type 2, #Metabolic syndrome, #Obesity] - Irisin is involved in promoting the browning of white adipose tissue, the regulation of energy metabolism, and the improvement of insulin resistance. [#Diabetes Type 2] - Irisin is increased in DM type 2 and perhaps in association with pro-atherogenic endothelial disorders. - fenugreek seeds can downregulate serum irisin levels, thus improved liver and kidney function in patients with DM type 2. - The study also showed that irisin concentration was downregulated during the amelioration of DM type 2 [#Diabetes Type 2] - #Vitamin D supplementation may improve DM type 2 by decreasing glycosylated hemoglobin (HbA1c) and increasing #Sirtuin 1 (SIRT1) and irisin in #Vitamin D-deficient patients with DM type 2 - #Pancreatic Cancer > irisin effectively inhibited the growth, migration, and invasion of these cell lines by regulating the AMP-activated protein kinase (AMPK)-mTOR pathway and suppressing the epithelial-mesenchymal transition.References Notes[ ]
