Disease ⇒ Amyotrophic lateral sclerosis {40000171}
Type: | Disease |
---|---|
Definition: | Amyotrophic lateral sclerosis |
Parent: | [ ] |
Initialisation date: | 2019-08-25 |
---|---|
Other Terms: | ALS |
MedDra ID: | 10002026 |
---|---|
MedDra Level: | pt |
ICD: | [ ] |
Category: | Neurology |
Zone: | [ ] |
Mechanism: | [ ] |
Notes:
[ ]
References Notes
[ ]
Shared Reference Notes
- [1.8]
- Nicotinamide produced by the Akkermansia muciniphila bacteria slowed disease progression and prolonged survival in an ALS mouse model.
- Nicotinamide benefits may be linked with improvements in mitochondria function.
- Nicotinamide and its intermediary molecules significantly reduced in ALS.
- Nicotinamide levels were decreased in the brains of ALS patients; this reduction was associated with enhanced muscle weakness.
- Ruminococcus torques and Parabacteroides distasonis worsened ALS symptoms (1) - [1.9]
- IL-8, IL-15, MCP-1 and VEGF-A levels were significantly lower in patients than controls, while others did not show a different distribution among groups.
- IP-10 levels were positively correlated with survival. - - The fecal SCFA concentrations (µmol/g) were not significantly different between ALS patients and controls, or between patients with different clinical characteristics.
- [1.6]
- Greater abundance of Ruminococcus, at genus level > related to higher risk of ALS.
- Kynurenine > risk factor of ALS. - [1.11]
- In spinal motor neurons human induced pluripotent stem cell lines > elevated levels of arachidonic acid.
- Pharmacological reduction of arachidonic acid levels > reverse ALS-related phenotypes in both human sMNs and in vivo in Drosophila and SOD1G93A mouse models. - [1.12]
- ALS in mice> altered bacterial community related to autoimmunity (e.g., Clostridium sp. ASF502, Lachnospiraceae bacterium A4), inflammation (e.g., Enterohabdus Muris,), and metabolism (e.g., Desulfovibrio fairfieldensis) at 1- and 2-month-old SOD1G93A mice, suggesting the early microbial contribution to the pathological changes. - [1.7]
- The gut microbial communities of the ALS patients were more diverse and were deficient in Prevotella spp. compared with those of their spouses.
- Predictive analysis of microbial enzymes revealed that ALS patients had decreased activity in several metabolic pathways, including carbon metabolism, butyrate metabolism, and systems involving histidine kinase and response regulators.