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Disease ⇒ Amyotrophic lateral sclerosis {40000171}

Record Keys


Type:
Disease
Definition:
Amyotrophic lateral sclerosis
Parent:[  ]

Details


Initialisation date:
2019-08-25
Other Terms:
ALS

Links


Meta Information


MedDra ID:
10002026
MedDra Level:
pt
ICD:[  ]
Category:
Neurology
Zone:[  ]
Mechanism:[  ]

Notes:


[  ]

References Notes


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Shared Reference Notes


  • [1.8
    - Nicotinamide produced by the Akkermansia muciniphila bacteria slowed disease progression and prolonged survival in an ALS mouse model.
    - Nicotinamide benefits may be linked with improvements in mitochondria function.
    - Nicotinamide and its intermediary molecules significantly reduced in ALS.
    - Nicotinamide levels were decreased in the brains of ALS patients; this reduction was associated with enhanced muscle weakness.
    - Ruminococcus torques and Parabacteroides distasonis worsened ALS symptoms (1)
  • [1.9
    - IL-8, IL-15, MCP-1 and VEGF-A levels were significantly lower in patients than controls, while others did not show a different distribution among groups.
    - IP-10 levels were positively correlated with survival.
  • - The fecal SCFA concentrations (µmol/g) were not significantly different between ALS patients and controls, or between patients with different clinical characteristics.
  • [1.6
    - Greater abundance of Ruminococcus, at genus level > related to higher risk of ALS.
    - Kynurenine > risk factor of ALS.
  • [1.11
    - In spinal motor neurons human induced pluripotent stem cell lines > elevated levels of arachidonic acid.
    - Pharmacological reduction of arachidonic acid levels > reverse ALS-related phenotypes in both human sMNs and in vivo in Drosophila and SOD1G93A mouse models.
  • [1.12
    - ALS in mice> altered bacterial community related to autoimmunity (e.g., Clostridium sp. ASF502, Lachnospiraceae bacterium A4), inflammation (e.g., Enterohabdus Muris,), and metabolism (e.g., Desulfovibrio fairfieldensis) at 1- and 2-month-old SOD1G93A mice, suggesting the early microbial contribution to the pathological changes.
  • [1.7
    - The gut microbial communities of the ALS patients were more diverse and were deficient in Prevotella spp. compared with those of their spouses.
    - Predictive analysis of microbial enzymes revealed that ALS patients had decreased activity in several metabolic pathways, including carbon metabolism, butyrate metabolism, and systems involving histidine kinase and response regulators.

Common References