Disease ⇒ Drug-resistant Epilepsy {40000395}

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Drug-resistant Epilepsy


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Shared Reference Notes

  • [1.1] [#Keto diet
    - ketogenic diet has been shown to increase the level of #GABA in the cerebrospinal fluid of children with refractory epilepsy
  • [1.2] [#Keto diet
    - The ketogenic diet (KD) has shown excellent performance in the treatment of refractory epilepsy
  • [1.3] [#Keto diet
    - #Reactive Oxygen Species is elevated during #Seizure activity due to #Oxidative stress-associated neuronal death, which can further contribute to epileptogenesis. - The KD reportedly reduces #Oxidative stress by promoting antioxidant enzymatic activity.
  • [#Keto diet] - Abnormal regulation of TORC1 signaling has been implicated in many epilepsies and is a therapeutic target. - The KD and select fatty acids inhibit TORC1 activity,
  • [#Keto diet] - Microbial genes related to fatty acid β-oxidation, 2-methylcitrate cycle, glycol metabolism, and #Proline biosynthesis were more highly represented in the gut microbiota of epileptic #Children after treatment with the KD compared to their internal pre-treatment controls

References Notes

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