Sign ⇒ Seizure {40000592}

Record Keys

Disease, Sign
Parent:[  ]


Initialisation date:[  ]
Other Terms:[  ]

Meta Information

MedDra ID:[  ]
MedDra Level:[  ]
ICD:[  ]
Category:[  ]
Zone:[  ]
Mechanism:[  ]


[  ]

Shared Reference Notes

  • [1.1
    - excessive neuronal activity accelerates glycolysis to generate #Lactate, which translocates to the extracellular space to slow neuronal firing and inhibit excitatory transmission via HCA1R. These studies may identify novel anticonvulsant target and seizure termination mechanisms.
  • [1.2] [#Drug-resistant Epilepsy] [#Keto diet
    - #Reactive Oxygen Species is elevated during seizure activity due to #Oxidative stress-associated neuronal death, which can further contribute to epileptogenesis. - The KD reportedly reduces #Oxidative stress by promoting antioxidant enzymatic activity.
  • [#Branched-chain amino acids] - BCAA derivatives are reported to promote G-protein phosphorylation, and abnormalities in GPCR-mediated neuronal signaling can contribute to seizure susceptibility.

References Notes

[  ]
MetaBiom only uses strictly necessary session cookies to give you the best possible experience on the website. By selecting "Accept essential cookies" you agree to the use of these cookies.