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Disease ⇒ Steatohepatitis {40000174}

Record Keys
Type:
Disease
Parent:[  ]
Definition:
Steatohepatitis

Details
Initialisation date:
2020-08-23
Other Terms:[  ]

Links

Meta Information
MedDra ID:[  ]
MedDra Level:[  ]
ICD:[  ]
Category:
Gastroenterology
Zone:[  ]
Mechanism:[  ]

Notes:

- Replacing depleted Akkermansia muciniphila bacteria in the guts of these mice helped ameliorate their inflammation and steatohepatitis. (1)

Shared Reference Notes

  • [1.1] 
    - #Bacteroides was negatively associated with advanced steatosis - Some species of #Bacteroides have been associated with progression to advanced liver fibrosis
  • - #Dorea is consistently associated with advanced MAFLD and steatohepatitis
  • - #Megasphaera is consistently associated with advanced MAFLD and steatohepatitis
  • [1.2] [#Polyphenol] 
    - Polyphenols > preventing hepatocellular damage through several possible mechanisms, including reducing de novo lipogenesis, increasing fatty acid oxidation and reducing oxidative stress> reducing liver steatosis. - Mixture of flavonoids > increase fatty acid oxidation in the liver > reduce inflammation by inhibition of nuclear factor kappa-light-chain-enhancer of activated B cells > increase adiponectin > reduce BP
  • [1.3] 
    - Duodenal dysbiosis with a dominance shift toward specific potential pathogenic bacteria genera (#Streptococcus, #Shuttleworthia, #Rothia), increased IP and elevated markers of microbial translocation characterized AUD patients with progressive ALD (steato-hepatitis, steato-fibrosis).
  • [1.4] [#Non alcoholic steatohepatitis, #Non-alcoholic fatty liver disease] [#Lipopolysaccharide, #TMA] 
    - A shift in the metabolic function of intestinal bacteria is predominantly caused by dysbiosis. In the intestine, it leads to an increase in the permeability of intestinal mucosa for LPS and ultimately causes chronic inflammation. Concentration of bacterial metabolites in the blood, such as trimethylamine which is metabolized in the liver to trimethylamine-N-oxide (#TMAO) correlates with the severity of steatohepatitis
  • [1.5] 
    - #Acetate, #Propionate, and #Butyrate have been shown to alleviate hepatic steatosis by activating AMP-activated protein kinase, expressing a fatty-acid oxidation gene, and inhibiting macrophage proinflammatory activation
  • [1.6] [#Diabetes Type 2, #Irritable bowel syndrome] 
    - Increased levels of #Ceramides were reported in mucosal samples from IBS patients as well as in plasma and tissue samples in diabetes, cardiomyopathy, insulin resistance, #Atherosclerosis and steatohepatitis.

References Notes

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